Progenitor cell-derived exosomes endowed with VEGF plasmids enhance osteogenic induction and vascular remodeling in large segmental bone defects.
Animals
Bone Regeneration
/ genetics
Bone and Bones
/ blood supply
Cell Adhesion
Cell Line
Cell Proliferation
Exosomes
/ genetics
Male
Materials Testing
Mice
Osteogenesis
/ genetics
Plasmids
/ genetics
Polyesters
Printing, Three-Dimensional
Radius
/ surgery
Rats
Stem Cells
Tissue Engineering
Tissue Scaffolds
Vascular Endothelial Growth Factor A
/ genetics
Vascular Remodeling
/ genetics
X-Ray Microtomography
3D printing
VEGF gene
anchor peptide
engineered exosome
vascularized osteogenesis
Journal
Theranostics
ISSN: 1838-7640
Titre abrégé: Theranostics
Pays: Australia
ID NLM: 101552395
Informations de publication
Date de publication:
2021
2021
Historique:
received:
16
07
2020
accepted:
22
09
2020
entrez:
4
1
2021
pubmed:
5
1
2021
medline:
6
8
2021
Statut:
epublish
Résumé
Large segmental bone regeneration remains a great challenge due to the lack of vascularization in newly formed bone. Conventional strategies primarily combine bone scaffolds with seed cells and growth factors to modulate osteogenesis and angiogenesis. Nevertheless, cell-based therapies have some intrinsic issues regarding immunogenicity, tumorigenesis, bioactivity and off-the-shelf transplantation. Exosomes are nano-sized (50-200 nm) extracellular vesicles with a complex composition of proteins, nucleic acids and lipids, which are attractive as therapeutic nanoparticles for disease treatment. Exosomes also have huge potential as desirable drug/gene delivery vectors in the field of regenerative medicine due to their excellent biocompatibility and efficient cellular internalization.
Identifiants
pubmed: 33391482
doi: 10.7150/thno.50741
pii: thnov11p0397
pmc: PMC7681080
doi:
Substances chimiques
Polyesters
0
Vascular Endothelial Growth Factor A
0
polycaprolactone
24980-41-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
397-409Informations de copyright
© The author(s).
Déclaration de conflit d'intérêts
Competing Interests: The authors have declared that no competing interest exists.
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