Functional Neuroimaging of Adult-to-Adult Romantic Attachment Separation, Rejection, and Loss: A Systematic Review.
Adult attachment
Dissolution
Rejection
Romantic relationship breakup
Separation
fMRI
Journal
Journal of clinical psychology in medical settings
ISSN: 1573-3572
Titre abrégé: J Clin Psychol Med Settings
Pays: United States
ID NLM: 9435680
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
accepted:
01
12
2020
pubmed:
5
1
2021
medline:
25
2
2023
entrez:
4
1
2021
Statut:
ppublish
Résumé
Romantic attachment rejection (RAR) is a highly prevalent phenomenon among young adults. Rejection by a romantic attachment figure can be a painful and incapacitating experience with lasting negative mental health sequelae, yet the underlying neurobiology of RAR is not well characterized. We systematically reviewed functional neuroimaging studies of adult RAR. Four functional magnetic resonance imaging (fMRI) studies that measured participants' responses to real or imagined RAR and met inclusion criteria were evaluated. These included studies were published between 2004 and 2018. Brain activity in adult participants with an RAR appears to be influenced by the stimulus used to elicit a reaction as well as by attachment styles. Brain regions that show a significant change in activation following a rejection stimulus include cortical regions (cingulate, insular, orbitofrontal, and prefrontal), and subcortical regions (angular gyrus, hippocampus, striatum, tegmental area, and temporal pole) and correspond to (i) pain, distress, and memory retrieval; (ii) reward, romantic love, and dopaminergic circuits; and (iii) emotion regulation and behavioural adaptation. Further neuroimaging studies of adult RAR, as moderated by stimulus and attachment style, are needed to better understand the underlying neurobiology of RAR.
Identifiants
pubmed: 33392890
doi: 10.1007/s10880-020-09757-x
pii: 10.1007/s10880-020-09757-x
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
637-648Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.
Références
Acosta, H., Jansen, A., Nuscheler, B., & Kircher, T. (2018). A voxel-based morphometry study on adult attachment style and affective loss. Neuroscience, 392, 219–229. https://doi.org/10.1016/j.neuroscience.2018.06.045 .
doi: 10.1016/j.neuroscience.2018.06.045
pubmed: 30005995
Alessi, E. J., Meyer, I. H., & Martin, J. I. (2013). PTSD and sexual orientation: An examination of criterion A1 and non-criterion A1 events. Psychological Trauma: Theory, Research, Practice, and Policy, 5, 149–157. https://doi.org/10.1037/a0026642 .
doi: 10.1037/a0026642
Arnett, J. J. (2000). Emerging adulthood: A theory of development from the late teens through the twenties. American Psychologist, 55, 469–480. https://doi.org/10.1037/0003-066X.55.5.469 .
doi: 10.1037/0003-066X.55.5.469
Barber, L. L., & Cooper, M. L. (2014). Rebound sex: Sexual motives and behaviors following a relationship breakup. Archives of Sexual Behavior, 43, 251–265. https://doi.org/10.1007/s10508-013-0200-3 .
doi: 10.1007/s10508-013-0200-3
pubmed: 24356947
Belu, C. F., Lee, B. H., & O’Sullivan, L. F. (2016). It hurts to let you go: Characteristics of romantic relationships, breakups and the aftermath among emerging adults. Journal of Relationships Research, 7, e11. https://doi.org/10.1017/jrr.2016.11 .
doi: 10.1017/jrr.2016.11
Benton, S. A., Robertson, J. M., Tseng, W.-C., Newton, F. B., & Benton, S. L. (2003). Changes in counseling center client problems across 13 years. Professional Psychology: Research and Practice, 34, 66–72. https://doi.org/10.1037/0735-7028.34.1.66 .
doi: 10.1037/0735-7028.34.1.66
Boelen, P. A., & Reijntjes, A. (2009). Negative cognitions in emotional problems following romantic relationship break-ups. Stress and Health, 25, 11–19. https://doi.org/10.1002/smi.1219 .
doi: 10.1002/smi.1219
Brenner, R. E., & Vogel, D. L. (2015). Measuring thought content valence after a breakup: Development of the positive and negative ex-relationship thoughts (PANERT) scale. Journal of Counseling Psychology, 62, 476–487. https://doi.org/10.1037/cou0000073 .
doi: 10.1037/cou0000073
pubmed: 25798872
Brooks, J. C. W., Zambreanu, L., Godinez, A., Craig, A. D., & Tracey, I. (2005). Somatotopic organisation of the human insula to painful heat studied with high resolution functional imaging. NeuroImage, 27, 201–209. https://doi.org/10.1016/j.neuroimage.2005.03.041 .
doi: 10.1016/j.neuroimage.2005.03.041
pubmed: 15921935
Buchheim, A., Erk, S., George, C., Kächele, H., Ruchsow, M., Spitzer, M., … Walter, H. (2006). Measuring attachment representation in an fMRI environment: A pilot study. Psychopathology, 39(3), 144–152. https://doi.org/10.1159/000091800 .
Bush, G., Luu, P., & Posner, M. I. (2000). Cognitive and emotional influences in anterior cingulate cortex. Trends in Cognitive Sciences, 4, 215–222.
doi: 10.1016/S1364-6613(00)01483-2
Chung, M. C., Farmer, S., Grant, K., Newton, R., Payne, S., … Stone, N. (2003). Coping with post-traumatic stress symptoms following relationship dissolution. Stress and Health, 19, 27–36. https://doi.org/10.1002/smi.956 .
Coan, J. A. (2010). Adult attachment and the brain. Journal of Social and Personal Relationships, 27, 210–217. https://doi.org/10.1177/0265407509360900 .
doi: 10.1177/0265407509360900
Davila, J., & Cobb, R. J. (2003). Predicting change in self-reported and interviewer-assessed adult attachment: Tests of the individual difference and life stress models of attachment change. Personality & Social Psychology Bulletin, 29, 859–870. https://doi.org/10.1177/0146167203029007005 .
doi: 10.1177/0146167203029007005
Davila, J., & Sargent, E. (2003). The meaning of life (events) predicts changes in attachment security. Personality & Social Psychology Bulletin, 29, 1383–1395. https://doi.org/10.1177/0146167203256374 .
doi: 10.1177/0146167203256374
Drum, D. J., Brownson, C., Burton Denmark, A., & Smith, S. E. (2009). New data on the nature of suicidal crises in college students: Shifting the paradigm. Professional Psychology: Research and Practice, 40, 213–222. https://doi.org/10.1037/a0014465 .
doi: 10.1037/a0014465
Dubé, A.-A., Duquette, M., Roy, M., Lepore, F., Duncan, G., & Rainville, P. (2009). Brain activity associated with the electrodermal reactivity to acute heat pain. NeuroImage, 45, 169–180. https://doi.org/10.1016/j.neuroimage.2008.10.024 .
doi: 10.1016/j.neuroimage.2008.10.024
pubmed: 19027077
Duyn, J. H. (2012). The future of ultra-high field MRI and fMRI for study of the human brain. NeuroImage, 62, 1241–1248. https://doi.org/10.1016/j.neuroimage.2011.10.065 .
doi: 10.1016/j.neuroimage.2011.10.065
pubmed: 22063093
Eichenbaum, H. (2004). An information processing framework for memory representation by the hippocampus. In M. Gazzaniga (Ed.), Cognitive neuroscience (3rd ed., pp. 679–690). Cambridge: MIT Press.
Engels, A. S., Heller, W., Spielberg, J. M., Warren, S. L., Sutton, B. P., … Miller, G. A. (2010). Co-occurring anxiety influences patterns of brain activity in depression. Cognitive, Affective, & Behavioral Neuroscience, 10, 141–156. https://doi.org/10.3758/CABN.10.1.141 .
Erikson, E. H. (1986). Identity: Yourth and crisis. Mountain View: Norton.
Field, T. (2011). Romantic breakups, heartbreak and bereavement—Romantic breakups. Psychology, 02, 382–387. https://doi.org/10.4236/psych.2011.24060 .
doi: 10.4236/psych.2011.24060
Field, T., Diego, M., Pelaez, M., Deeds, O., & Delgado, J. (2009). Breakup distress in university students. Adolescence, 44, 705–727.
pubmed: 20432597
Fisher, H. E., Brown, L. L., Aron, A., Strong, G., & Mashek, D. (2010). Reward, addiction, and emotion regulation systems associated with rejection in love. Journal of Neurophysiology, 104, 51–60. https://doi.org/10.1152/jn.00784.2009 .
doi: 10.1152/jn.00784.2009
pubmed: 20445032
Fox, J., & Tokunaga, R. S. (2015). Romantic partner monitoring after breakups: Attachment, dependence, distress, and post-dissolution online surveillance via social networking sites. Cyberpsychology, Behavior, and Social Networking, 18, 491–498. https://doi.org/10.1089/cyber.2015.0123 .
doi: 10.1089/cyber.2015.0123
Fraley, R. C. (2002). Attachment stability from infancy to adulthood: Meta-analysis and dynamic modeling of developmental mechanisms. Personality and Social Psychology Review, 6, 123–151. https://doi.org/10.1207/S15327957PSPR0602_03 .
doi: 10.1207/S15327957PSPR0602_03
Fraley, R. C. (2019). Attachment in adulthood: Recent developments, emerging debates, and future directions. Annual Review of Psychology, 70, 401–422. https://doi.org/10.1146/annurev-psych-010418-102813 .
doi: 10.1146/annurev-psych-010418-102813
pubmed: 30609910
Fraley, R. C., Vicary, A. M., Brumbaugh, C. C., & Roisman, G. I. (2011). Patterns of stability in adult attachment: An empirical test of two models of continuity and change. Journal of Personality and Social Psychology, 101, 974–992. https://doi.org/10.1037/a0024150 .
doi: 10.1037/a0024150
pubmed: 21707199
Gebhardt, W. A., Van Der Doef, M. P., Massey, E. K., & Verkuil, B. (2010). Goal commitment to finding a partner and satisfaction with life among female singles: The mediating role of rumination. Journal of Health Psychology, 15, 122–130. https://doi.org/10.1177/1359105309346212 .
doi: 10.1177/1359105309346212
pubmed: 20064891
George, M. S., Ketter, T. A., Parekh, P. I., Herscovitch, P., & Post, R. M. (1996). Gender differences in regional cerebral blood flow during transient self-induced sadness or happiness. Biological Psychiatry, 40, 859–871. https://doi.org/10.1016/0006-3223(95)00572-2 .
doi: 10.1016/0006-3223(95)00572-2
pubmed: 8896772
Gillath, O., Bunge, S. A., Shaver, P. R., Wendelken, C., & Mikulincer, M. (2005). Attachment-style differences in the ability to suppress negative thoughts: Exploring the neural correlates. NeuroImage, 28, 835–847. https://doi.org/10.1016/j.neuroimage.2005.06.048 .
doi: 10.1016/j.neuroimage.2005.06.048
pubmed: 16087352
Greenhalgh, T. (2005). Effectiveness and efficiency of search methods in systematic reviews of complex evidence: Audit of primary sources. BMJ, 331, 1064–1065. https://doi.org/10.1136/bmj.38636.593461.68 .
doi: 10.1136/bmj.38636.593461.68
pubmed: 16230312
pmcid: 1283190
Hadland, K., Rushworth, M. F., Gaffan, D., & Passingham, R. (2003). The effect of cingulate lesions on social behaviour and emotion. Neuropsychologia, 41, 919–931. https://doi.org/10.1016/S0028-3932(02)00325-1 .
doi: 10.1016/S0028-3932(02)00325-1
pubmed: 12667528
Hamilton, J. P., Sacchet, M. D., Hjørnevik, T., Chin, F. T., Shen, B., … Gotlib, I. H. (2018). Striatal dopamine deficits predict reductions in striatal functional connectivity in major depression: A concurrent 11 C-raclopride positron emission tomography and functional magnetic resonance imaging investigation. Translational Psychiatry. https://doi.org/10.1038/s41398-018-0316-2
Hazan, C., & Shaver, P. R. (1990). Love and work: An attachment-theoretical perspective. Journal of Personality and Social Psychology, 59, 270–280. https://doi.org/10.1037/0022-3514.59.2.270 .
doi: 10.1037/0022-3514.59.2.270
Kendler, K. S., Hettema, J. M., Butera, F., Gardner, C. O., & Prescott, C. A. (2003). Life event dimensions of loss, humiliation, entrapment, and danger in the prediction of onsets of major depression and generalized anxiety. Archives of General Psychiatry, 60, 789. https://doi.org/10.1001/archpsyc.60.8.789 .
doi: 10.1001/archpsyc.60.8.789
pubmed: 12912762
Kose, S., & George, M. (2003). Functional magnetic resonance imaging investigations in mood disorders. In J. Soares (Ed.), Brain imaging in affective disorders (pp. 119–157). New York: Marcel Dekker.
Kringelbach, M. L., & Rolls, E. T. (2004). The functional neuroanatomy of the human orbitofrontal cortex: evidence from neuroimaging and neuropsychology. Progress in Neurobiology, 72, 341–372. https://doi.org/10.1016/j.pneurobio.2004.03.006 .
doi: 10.1016/j.pneurobio.2004.03.006
pubmed: 15157726
Labek, K., Viviani, R., Gizewski, E. R., Verius, M., & Buchheim, A. (2016). Neural correlates of the appraisal of attachment scenes in healthy controls and social cognition—An fMRI study. Frontiers in Human Neuroscience. https://doi.org/10.3389/fnhum.2016.00345 .
doi: 10.3389/fnhum.2016.00345
pubmed: 27458363
pmcid: 4932100
Lannutti, P. J., & Cameron, K. A. (2002). Beyond the breakup: Heterosexual and homosexual post-dissolutional relationships. Communication Quarterly, 50, 153–170. https://doi.org/10.1080/01463370209385654 .
doi: 10.1080/01463370209385654
Lyons-Ruth, K. (2007). The interface between attachment and intersubjectivity: Perspective from the longitudinal study of disorganized attachment. Psychoanalytic Inquiry, 26, 595–616. https://doi.org/10.1080/07351690701310656 .
doi: 10.1080/07351690701310656
MacDonald, G., & Leary, M. R. (2005). Why does social exclusion hurt? The relationship between social and physical pain. Psychological Bulletin, 131, 202–223. https://doi.org/10.1037/0033-2909.131.2.202 .
doi: 10.1037/0033-2909.131.2.202
pubmed: 15740417
Mearns, J. (1991). Coping with a breakup: Negative mood regulation expectancies and depression following the end of a romantic relationship. Journal of Personality and Social Psychology, 60, 327–334. https://doi.org/10.1037/0022-3514.60.2.327 .
doi: 10.1037/0022-3514.60.2.327
pubmed: 2016673
Meier, A., & Allen, G. (2009). Romantic relationships from adolescence to young adulthood: Evidence from the national longitudinal study of adolescent health. The Sociological Quarterly, 50, 308–335. https://doi.org/10.1111/j.1533-8525.2009.01142.x .
doi: 10.1111/j.1533-8525.2009.01142.x
pubmed: 25332511
pmcid: 4201847
Meyer, I. H. (2003). Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: Conceptual issues and research evidence. Psychological Bulletin, 129, 674–697. https://doi.org/10.1037/0033-2909.129.5.674 .
doi: 10.1037/0033-2909.129.5.674
pubmed: 12956539
pmcid: 2072932
Mikulincer, M., Dolev, T., & Shaver, P. R. (2004). Attachment-related strategies during thought suppression: Ironic rebounds and vulnerable self-representations. Journal of Personality and Social Psychology, 87, 940–956. https://doi.org/10.1037/0022-3514.87.6.940 .
doi: 10.1037/0022-3514.87.6.940
pubmed: 15598116
Mikulincer, M., & Florian, V. (2000). Exploring individual differences in reactions to mortality salience: Does attachment style regulate terror management mechanisms? Journal of Personality and Social Psychology, 79, 260–273.
doi: 10.1037/0022-3514.79.2.260
Mikulincer, M., & Orbach, I. (1995). Attachment styles and repressive defensiveness: The accessibility and architecture of affective memories. Journal of Personality and Social Psychology, 68, 917–925.
doi: 10.1037/0022-3514.68.5.917
Mikulincer, M., & Shaver, P. R. (2007). Attachment in adulthood: Structure, dynamics, and change. New York: Guilford Press.
Morris, C. E., Reiber, C., & Roman, E. (2015). Quantitative sex differences in response to the dissolution of a romantic relationship. Evolutionary Behavioral Sciences, 9, 270–282. https://doi.org/10.1037/ebs0000054 .
doi: 10.1037/ebs0000054
Moutsiana, C., Johnstone, T., Murray, L., Fearon, P., Cooper, P. J., … Halligan, S. L. (2015). Insecure attachment during infancy predicts greater amygdala volumes in early adulthood. Journal of Child Psychology and Psychiatry, 56, 540–548. https://doi.org/10.1111/jcpp.12317 .
Najib, A., Lorberbaum, J. P., Kose, S., Bohning, D. E., & George, M. S. (2004). Regional brain activity in women greiving a romantic relationship breakup. American Journal of Psychology, 161, 2245–2256. https://doi.org/10.1176/appi.ajp.161.12.2245 .
doi: 10.1176/appi.ajp.161.12.2245
Nolen-Hoeksema, S., Larson, J., & Grayson, C. (1999). Explaining the gender difference in depressive symptoms. Journal of Personality and Social Psychology, 77, 1061–1072.
doi: 10.1037/0022-3514.77.5.1061
Oquendo, M. A., Turret, J., Grunebaum, M. F., Burke, A. K., Poh, E., … Galfalvy, H. (2013). Sex differences in clinical predictors of depression: a prospective study. Journal of Affective Disorders, 150(3), 1179–1183. https://doi.org/10.1016/j.jad.2013.05.010 .
Ortigue, S., Bianchi-Demicheli, F., Hamilton, AFdeC., & Grafton, S. T. (2007). The neural basis of love as a subliminal prime: An event-related functional magnetic resonance imaging study. Journal of Cognitive Neuroscience, 19, 1218–1230. https://doi.org/10.1162/jocn.2007.19.7.121 .
doi: 10.1162/jocn.2007.19.7.121
pubmed: 17583996
Ouzzani, M., Hammady, H., Fedorowicz, Z., & Elmagarmid, A. (2016). Rayyan-a web and mobile app for systematic reviews. Systematic Reviews, 5, 210. https://doi.org/10.1186/s13643-016-0384-4 .
doi: 10.1186/s13643-016-0384-4
pubmed: 27919275
pmcid: 27919275
Perilloux, C., & Buss, D. M. (2008). Breaking up romantic relationships: Costs experienced and coping strategies deployed. Evolutionary Psychology, 6, 147470490800600. https://doi.org/10.1177/147470490800600119 .
doi: 10.1177/147470490800600119
Rainville, P., Duncan, G. H., Price, D. D., Carrier, B., & Bushnell, M. C. (1997). Pain affect encoded in human anterior cingulate but not somatosensory cortex. Science (New York, N.Y.), 277, 968–971.
doi: 10.1126/science.277.5328.968
Read, D. L., Clark, G. I., Rock, A. J., & Coventry, W. L. (2018). Adult attachment and social anxiety: The mediating role of emotion regulation strategies. PLoS ONE, 13, e0207514. https://doi.org/10.1371/journal.pone.0207514 .
doi: 10.1371/journal.pone.0207514
pubmed: 30592712
pmcid: 6310265
Ridderinkhof, K. R., Ullsperger, M., Crone, E. A., & Nieuwenhuis, S. (2004a). The role of the medial frontal cortex in cognitive control. Science (New York, N.Y.), 306, 443–447. https://doi.org/10.1126/science.1100301 .
doi: 10.1126/science.1100301
Ridderinkhof, K. R., van den Wildenberg, W. P. M., Segalowitz, S. J., & Carter, C. S. (2004b). Neurocognitive mechanisms of cognitive control: The role of prefrontal cortex in action selection, response inhibition, performance monitoring, and reward-based learning. Brain and Cognition, 56, 129–140. https://doi.org/10.1016/j.bandc.2004.09.016 .
doi: 10.1016/j.bandc.2004.09.016
pubmed: 15518930
Ross, L. E., Grigoriadis, S., Mamisashvili, L., Koren, G., Steiner, M., … Mousmanis, P. (2011). Quality assessment of observational studies in psychiatry: an example from perinatal psychiatric research. International Journal of Methods in Psychiatric Research, 20, 224–234. https://doi.org/10.1002/mpr.356 .
Sbarra, D. A., & Hazan, C. (2008). Coregulation, dysregulation, self-regulation: An integrative analysis and empirical agenda for understanding adult attachment, separation, loss, and recovery. Personality and Social Psychology Review, 12, 141–167. https://doi.org/10.1177/1088868308315702 .
doi: 10.1177/1088868308315702
pubmed: 18453476
Schore, A. N. (2003). Affect regulation and disorders of the self. Mountain View: Norton.
Schore, A. N. (2009). Right brain affect regulation: An essential mechanism of development, trauma, dissociation, and psychotherapy. In D. E. Fosha, D. J. Siegel, & M. F. Solomon (Eds.), The healing power of emotion: Affective neuroscience, development, clinical practice. Mountain View: Norton.
Shaver, P. R., & Mikulincer, M. (2008). Adult attachment and cognitive and affective reactions to positive and negative events. Social and Personality Psychology Compass, 2, 1844–1865. https://doi.org/10.1111/j.1751-9004.2008.00146.x .
doi: 10.1111/j.1751-9004.2008.00146.x
Shulman, S., & Connolly, J. (2013). The challenge of romantic relationships in emerging adulthood: Reconceptualization of the field. Emerging Adulthood, 1, 27–39. https://doi.org/10.1177/2167696812467330 .
doi: 10.1177/2167696812467330
Townsend, J. D., Eberhart, N. K., Bookheimer, S. Y., Eisenberger, N. I., Foland-Ross, L. C., … Altshuler, L. L. (2010). fMRI activation in the amygdala and the orbitofrontal cortex in unmedicated subjects with major depressive disorder. Psychiatry Research: Neuroimaging, 183, 209–217. https://doi.org/10.1016/j.pscychresns.2010.06.001
Treede, R. D., Apkarian, A. V., Bromm, B., Greenspan, J. D., & Lenz, F. A. (2000). Cortical representation of pain: functional characterization of nociceptive areas near the lateral sulcus. Pain, 87, 113–119.
doi: 10.1016/S0304-3959(00)00350-X
Vrtička, P., & Vuilleumier, P. (2012). Neuroscience of human social interactions and adult attachment style. Frontiers in Human Neuroscience. https://doi.org/10.3389/fnhum.2012.00212 .
doi: 10.3389/fnhum.2012.00212
pubmed: 23346054
pmcid: 3398354
Wallin, D. J. (2007). Attachment in psychotherapy. Psychoanalytic social work. New York: Guilford Press.
Weissman, M. M., Bland, R. C., Canino, G. J., Faravelli, C., Greenwald, S., … Yeh, E. K. (1996). Cross-national epidemiology of major depression and bipolar disorder. JAMA, 276, 293–299
Yttredahl, A. A., McRobert, E., Sheler, B., Mickey, B. J., Love, T. M., … Hsu, D. T. (2018). Abnormal emotional and neural responses to romantic rejection and acceptance in depressed women. Journal of Affective Disorders, 234, 231–238. https://doi.org/10.1016/j.jad.2018.02.083