IRC-Fuse: improved and robust prediction of redox-sensitive cysteine by fusing of multiple feature representations.
Feature selection
Machine learning
PseAAC
Redox-sensitive cysteine
Sequence profile information
Journal
Journal of computer-aided molecular design
ISSN: 1573-4951
Titre abrégé: J Comput Aided Mol Des
Pays: Netherlands
ID NLM: 8710425
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
11
06
2020
accepted:
06
12
2020
pubmed:
5
1
2021
medline:
6
1
2022
entrez:
4
1
2021
Statut:
ppublish
Résumé
Redox-sensitive cysteine (RSC) thiol contributes to many biological processes. The identification of RSC plays an important role in clarifying some mechanisms of redox-sensitive factors; nonetheless, experimental investigation of RSCs is expensive and time-consuming. The computational approaches that quickly and accurately identify candidate RSCs using the sequence information are urgently needed. Herein, an improved and robust computational predictor named IRC-Fuse was developed to identify the RSC by fusing of multiple feature representations. To enhance the performance of our model, we integrated the probability scores evaluated by the random forest models implementing different encoding schemes. Cross-validation results exhibited that the IRC-Fuse achieved accuracy and AUC of 0.741 and 0.807, respectively. The IRC-Fuse outperformed exiting methods with improvement of 10% and 13% on accuracy and MCC, respectively, over independent test data. Comparative analysis suggested that the IRC-Fuse was more effective and promising than the existing predictors. For the convenience of experimental scientists, the IRC-Fuse online web server was implemented and publicly accessible at http://kurata14.bio.kyutech.ac.jp/IRC-Fuse/ .
Identifiants
pubmed: 33392948
doi: 10.1007/s10822-020-00368-0
pii: 10.1007/s10822-020-00368-0
doi:
Substances chimiques
Proteins
0
Sulfhydryl Compounds
0
Cysteine
K848JZ4886
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
315-323Références
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