The impact of bisphosphonates on postoperative complication rates in osteoporotic patients undergoing posterior lumbar fusion.
Bisphosphonates
Complications
Osteoporosis
PearlDiver
Spine fusion
Journal
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
ISSN: 1432-0932
Titre abrégé: Eur Spine J
Pays: Germany
ID NLM: 9301980
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
26
05
2020
accepted:
22
12
2020
pubmed:
5
1
2021
medline:
6
7
2021
entrez:
4
1
2021
Statut:
ppublish
Résumé
To elucidate the effects of bisphosphonates on complications following posterior lumbar fusion (PLF) with a large database study. The PearlDiver Patient Record Database was queried to identify adult patients who had undergone posterior lumbar fusion (PLF). Those patient cohorts were divided based on a diagnosis of osteoporosis prior to surgery and bisphosphonate usage. This yielded three groups: Osteo+Bisph+, Osteo+Bisph-, and Osteo-Bisph-. The primary outcome of the present study was revision rates at 6 months and 1 year following surgery. Incidence of postoperative complications was analyzed, and statistical analysis was conducted using Pearson chi-square analysis. Patients taking bisphosphonates did not have significantly different rates of revision surgery at 6 months and 1 year, instrumentation complications, or post-vertebral fractures than patients not taking bisphosphonates. Additionally, osteoporotic patients did not have significantly different rates of these complications than patients without osteoporosis. Bisphosphonate usage did not significantly affect the rates of postoperative complications following posterior lumbar fusion. Further research is required to fully elucidate the effects of bisphosphonates on outcomes and complications following spine surgery.
Identifiants
pubmed: 33394089
doi: 10.1007/s00586-020-06706-y
pii: 10.1007/s00586-020-06706-y
doi:
Substances chimiques
Diphosphonates
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1329-1336Références
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