Alcohol use and dementia: new research directions.
Journal
Current opinion in psychiatry
ISSN: 1473-6578
Titre abrégé: Curr Opin Psychiatry
Pays: United States
ID NLM: 8809880
Informations de publication
Date de publication:
01 03 2021
01 03 2021
Historique:
pubmed:
5
1
2021
medline:
18
9
2021
entrez:
4
1
2021
Statut:
ppublish
Résumé
Alcohol is gaining increased recognition as an important risk factor for dementia. This review summarises recent evidence on the relationship between alcohol use and dementia, focusing on studies published from January 2019 to August 2020. Epidemiological data continues to yield results consistent with protective effects of low-to-moderate alcohol consumption for dementia and cognitive function. However, recent literature highlights the methodological limitations of existing observational studies. The effects of chronic, heavy alcohol use are clearer, with excessive consumption causing alcohol-related brain damage. Several pathways to this damage have been suggested, including the neurotoxic effects of thiamine deficiency, ethanol and acetaldehyde. Future research would benefit from greater implementation of analytical and design-based approaches to robustly model the alcohol use-dementia relationship in the general population, and should make use of large, consortia-level data. Early intervention to prevent dementia is critical: thiamine substitution has shown potential but requires more research, and psychosocial interventions to treat harmful alcohol use have proven effective. Finally, diagnostic criteria for alcohol-related dementia require formal validation to ensure usefulness in clinical practice.
Identifiants
pubmed: 33394727
doi: 10.1097/YCO.0000000000000679
pii: 00001504-202103000-00015
doi:
Substances chimiques
Protective Agents
0
Ethanol
3K9958V90M
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
165-170Informations de copyright
Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.
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