Topological reorganization of brain functional networks in patients with mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes.
Brain functional networks
Graph theory analysis
MELAS
Resting state
Journal
NeuroImage. Clinical
ISSN: 2213-1582
Titre abrégé: Neuroimage Clin
Pays: Netherlands
ID NLM: 101597070
Informations de publication
Date de publication:
2020
2020
Historique:
received:
30
06
2020
revised:
16
10
2020
accepted:
19
10
2020
entrez:
5
1
2021
pubmed:
6
1
2021
medline:
29
6
2021
Statut:
ppublish
Résumé
Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) is a rare maternally inherited genetic disease; however, little is known about its underlying brain basis. Furthermore, the topological organization of brain functional network in MELAS has not been explored. Here, 45 patients with MELAS (22 at acute stage, 23 at chronic stage) and 22 normal controls were studied using resting- state functional magnetic resonance imaging and graph theory analysis approaches. Topological properties of brain functional networks including global and nodal metrics, rich club organization and modularity were analyzed. At the global level, MELAS patients exhibited reduced clustering coefficient, normalized clustering coefficient, normalized characteristic path length and local network efficiency compared with the controls. At the nodal level, several nodes with abnormal degree centrality and nodal efficiency were detected in MELAS patients, and the distribution of these nodes was partly consistent with the stroke-like lesions. For rich club organization, rich club nodes were reorganized and the connections among them were decreased in MELAS patients. Modularity analysis revealed that MELAS patents had altered intra- or inter-modular connections in default mode network, fronto-parietal network, sensorimotor network, occipital network and cerebellum network. Notably, the patients at acute stage showed more obvious changes in these topological properties than the patients at chronic stage. These findings indicated that MELAS patients, particularly those at acute stage, exhibited topological reorganization of the whole-brain functional network. This study may help us to understand the neuropathological mechanisms of MELAS.
Identifiants
pubmed: 33395972
pii: S2213-1582(20)30317-X
doi: 10.1016/j.nicl.2020.102480
pmc: PMC7645289
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102480Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
Copyright © 2020. Published by Elsevier Inc.
Références
AJNR Am J Neuroradiol. 2020 Jan;41(1):167-173
pubmed: 31806591
Biochim Biophys Acta. 2012 May;1820(5):619-24
pubmed: 21443929
Brain Dev. 2011 Apr;33(4):283-8
pubmed: 20609541
Neurology. 2018 May 22;90(21):e1879-e1888
pubmed: 29678937
Cereb Cortex. 2014 Jun;24(6):1529-39
pubmed: 23349223
Curr Pain Headache Rep. 2016 Sep;20(9):54
pubmed: 27477183
Brain. 2014 Feb;137(Pt 2):598-609
pubmed: 24163276
Cereb Cortex. 2005 Mar;15(3):325-31
pubmed: 15269109
J Neurosci. 2010 Jul 14;30(28):9477-87
pubmed: 20631176
Nature. 1990 Dec 13;348(6302):651-3
pubmed: 2102678
J Comput Assist Tomogr. 2018 Jul/Aug;42(4):510-516
pubmed: 29369945
Proc Natl Acad Sci U S A. 2014 May 20;111(20):7438-43
pubmed: 24799682
Neuroimage. 2009 Oct 1;47(4):1408-16
pubmed: 19442749
Ann Neurol. 1984 Oct;16(4):481-8
pubmed: 6093682
Neurobiol Aging. 2019 Mar;75:71-82
pubmed: 30553155
Brain Struct Funct. 2017 Mar;222(2):1053-1060
pubmed: 26725108
JAMA Neurol. 2016 May 1;73(5):591-4
pubmed: 26954033
Neuroimage. 2009 Feb 1;44(3):893-905
pubmed: 18976716
Semin Neurol. 2002 Dec;22(4):375-84
pubmed: 12539058
Neuroinformatics. 2016 Jul;14(3):339-51
pubmed: 27075850
Cereb Cortex. 2020 Jan 10;30(1):269-282
pubmed: 31044223
Nat Rev Neurosci. 2002 Mar;3(3):201-15
pubmed: 11994752
Neuroimage. 2013 Feb 15;67:283-97
pubmed: 23194819
Science. 2010 Sep 10;329(5997):1358-61
pubmed: 20829489
Neurology. 2011 Nov 29;77(22):1965-71
pubmed: 22094475
J Psychiatry Neurosci. 2018 Aug;43(5):298-316
pubmed: 30125243
Brain. 2017 Apr 1;140(4):1068-1085
pubmed: 28334882
Brain Inform. 2015 Mar;2(1):45-52
pubmed: 27747502
Neurobiol Aging. 2013 Aug;34(8):2023-36
pubmed: 23541878
J Neurol. 2019 Jun;266(6):1459-1472
pubmed: 30888501
Neuroscientist. 2017 Oct;23(5):499-516
pubmed: 27655008
Clin Neuroradiol. 2019 Jun;29(2):321-329
pubmed: 29464268
Brain Struct Funct. 2016 Sep;221(7):3503-19
pubmed: 26420277
Nat Rev Neurosci. 2009 Mar;10(3):186-98
pubmed: 19190637
PLoS One. 2013 Jul 04;8(7):e68910
pubmed: 23861951
Brain. 2016 Dec;139(Pt 12):3063-3083
pubmed: 27497487
Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11372-7
pubmed: 22711833
Front Hum Neurosci. 2015 Jun 30;9:386
pubmed: 26175682
Schizophr Res. 2019 Jun;208:160-166
pubmed: 30967317
Annu Rev Psychol. 2016;67:613-40
pubmed: 26393868
Psychol Med. 2019 Feb;49(3):510-518
pubmed: 29734951
Front Neurol. 2018 Jul 27;9:621
pubmed: 30140253
Int J Comput Assist Radiol Surg. 2013 Jul;8(4):607-20
pubmed: 23588509
Magn Reson Med. 1995 Oct;34(4):537-41
pubmed: 8524021
J Neurosci. 2011 Nov 2;31(44):15775-86
pubmed: 22049421
Neuroimage. 2014 Jan 1;84:320-41
pubmed: 23994314
Curr Opin Neurol. 2010 Aug;23(4):341-50
pubmed: 20581686
Annu Rev Neurosci. 2015 Jul 8;38:433-47
pubmed: 25938726
Neuroimage. 2010 Sep;52(3):1059-69
pubmed: 19819337
Neurosci Biobehav Rev. 2017 Jun;77:286-300
pubmed: 28389343
JAMA Psychiatry. 2017 Jan 1;74(1):76-84
pubmed: 27851842
JAMA Psychiatry. 2013 Aug;70(8):783-92
pubmed: 23739835
PLoS One. 2013 Oct 28;8(10):e77336
pubmed: 24204812
J Neurophysiol. 2009 Jun;101(6):3270-83
pubmed: 19339462
Mol Genet Metab. 2015 Sep-Oct;116(1-2):4-12
pubmed: 26095523
Neurology. 2002 Sep 24;59(6):816-24
pubmed: 12297560
J Neurophysiol. 2011 Sep;106(3):1125-65
pubmed: 21653723
Magn Reson Med. 1996 Mar;35(3):346-55
pubmed: 8699946
J Psychiatr Res. 2019 Mar;110:51-56
pubmed: 30594024
Ann N Y Acad Sci. 2011 Apr;1224:109-125
pubmed: 21251014
Hum Brain Mapp. 2017 Jan;38(1):109-119
pubmed: 27548880