None
immunochemotherapy
molecular probe technique
monoclonal antibody
radio-guided surgery
radiopharmaceutical
Journal
Current radiopharmaceuticals
ISSN: 1874-4729
Titre abrégé: Curr Radiopharm
Pays: United Arab Emirates
ID NLM: 101468718
Informations de publication
Date de publication:
2022
2022
Historique:
received:
05
05
2020
revised:
27
10
2020
accepted:
05
11
2020
pubmed:
6
1
2021
medline:
13
4
2022
entrez:
5
1
2021
Statut:
ppublish
Résumé
Nimotuzumab is a humanized anti-epidermal growth factor receptor (EGFR) monoclonal antibody, nowadays used for tumour immunochemotherapy. This study aimed to label the conjugate DOTA-nimotuzumab with yttrium-90, in order to provide a β- emitting radioimmunoconjugate ( The synthesis of 90Y-DOTA-nimotuzumab was performed in two days. Nimotuzumab was conjugated with a 50-fold excess of DOTA and then labelled with 90Y3+. The The radioimmunoconjugate The optimized conditions for a mild and easy preparation of
Sections du résumé
BACKGROUND
BACKGROUND
Nimotuzumab is a humanized anti-epidermal growth factor receptor (EGFR) monoclonal antibody, nowadays used for tumour immunochemotherapy. This study aimed to label the conjugate DOTA-nimotuzumab with yttrium-90, in order to provide a β- emitting radioimmunoconjugate (
METHODS
METHODS
The synthesis of 90Y-DOTA-nimotuzumab was performed in two days. Nimotuzumab was conjugated with a 50-fold excess of DOTA and then labelled with 90Y3+. The
RESULTS
RESULTS
The radioimmunoconjugate
CONCLUSIONS
CONCLUSIONS
The optimized conditions for a mild and easy preparation of
Identifiants
pubmed: 33397277
pii: CRP-EPUB-113035
doi: 10.2174/1874471013999210104220031
doi:
Substances chimiques
Antibodies, Monoclonal
0
Antibodies, Monoclonal, Humanized
0
Antineoplastic Agents
0
Heterocyclic Compounds
0
Immunoconjugates
0
Organometallic Compounds
0
Radiopharmaceuticals
0
Yttrium Radioisotopes
0
yttrium(III)-1,4,7,10-tetraazacyclotetradecane-N,N',N'',N'''-tetraacetic acid
0
Yttrium-90
1K8M7UR6O1
nimotuzumab
6NS400BXKH
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
32-39Subventions
Organisme : Fondo di Ateneo Sapienza
ID : RM11715C7D2B14C5
Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.