Effects and interaction of dietary electrolyte balance and citric acid on growth performance, intestinal histomorphology, digestive enzyme activity and nutrient transporters expression of weaned piglets.
dietary electrolyte balance
digestive enzyme activities
enterocyte proliferation
intestinal morphology
nutrient transporters
Journal
Journal of animal physiology and animal nutrition
ISSN: 1439-0396
Titre abrégé: J Anim Physiol Anim Nutr (Berl)
Pays: Germany
ID NLM: 101126979
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
04
07
2020
accepted:
19
11
2020
pubmed:
6
1
2021
medline:
16
10
2021
entrez:
5
1
2021
Statut:
ppublish
Résumé
Fifty-six piglets were weaned at 21 days and randomly assigned to 1 of 8 dietary treatments with 7 replicate pens for a 14-day experimental period. The eight experimental diets were prepared via a 2 × 4 factorial arrangement with citric acid (CA; 0 and 0.3%) and dietary electrolyte balance (dEB, Na +K - Cl mEq/kg of the diet; -50, 100, 250, and 400 mEq/kg). Varying dEB values were obtained by altering calcium chloride and sodium bicarbonate contents. Dietary CA significantly increased (p < .05) villus height (VH) and villus height:crypt depth (VH:CD) in the jejunum. Piglets fed a 250 mEq/kg diet increased (p < .05) VH and VH:CD values in the duodenum. Jejunal VH and VH:CD increased (quadratic; p < .05), and ileal VH:CD (liner and quadratic; p < .05) decreased as dEB was increased in diets without CA, but no such effect was observed on the diets containing CA (dEB ×CA; p < .05). The CD in jejunum (quadratic; p < .05) increased as dEB was increased in diets containing CA, whereas it was decreased (linear; p < .05) in the diets without CA (dEB ×CA; p < .001). Dietary CA increased maltase activity and reduced the number of Ki67-positive cells (p < .05). Increasing dEB values in diets without CA increased sucrose and lactase activities (quadratic; p < .05), but no such effect was observed in the diets with CA (dEB ×CA; p < .05). An interaction effect between dEB and CA on the number of Ki67-positive cells was observed (p < .001). In conclusion, 250 mEq/kg dEB diet with CA improved piglet intestinal digestion and absorption function by improving intestinal morphology and increasing digestive enzyme activities. However, these improvements were also observed in piglets fed the 100 mEq/kg dEB diet without CA.
Substances chimiques
Citric Acid
2968PHW8QP
Types de publication
Journal Article
Randomized Controlled Trial, Veterinary
Langues
eng
Sous-ensembles de citation
IM
Pagination
272-285Subventions
Organisme : Key programs of frontier scientific research of the Chinese Academy of Sciences
ID : QYZDY-SSW-SMC008
Organisme : National Key R & D Program
ID : 2016YFD0501201
Organisme : Innovation Platform and Thousands Talents Program of Human Provincial Science and Technology Department
ID : 2018RS3105
Organisme : Natural Science Foundation of Hunan Province
ID : 2017JJ1020
Informations de copyright
© 2021 Wiley-VCH GmbH.
Références
AOAC (2007). Official methods of analysis, 18th ed. AOAC.
Bates, J. M., Akerlund, J., Mittge, E., & Guillemin, K. (2007). Intestinal alkaline phosphatase detoxifies lipopolysaccharide and prevents inflammation in zebrafish in response to the gut microbiota. Cell Host & Microbe, 2, 371-382. https://doi.org/10.1016/j.chom.2007.10.010
Buddington, R. K., Elnif, J., Puchal-Gardiner, A. A., & Sangild, P. T. (2001). Intestinal apical amino acid absorption during development of the pig. American Journal of Physiology-regulatory Integrative and Comparative Physiology, 280, R241-R247. https://doi.org/10.1152/ajpregu.2001.280.1.r241
Chen, C. C., Wang, Z. B., Li, J. Z., Li, Y. L., Huang, P. F., Yang, S. H., & Yin, Y. L. (2019). Dietary vitamin E affect small intestinal histomorphology, digestive enzyme activity and the expression of nutrient transporters by inhibiting proliferation of intestinal epithelial cells within jejunum in weaned piglets. Journal of Animal Science, 97, 1212-1221. https://doi.org/10.1093/jas/skz023
Chen, C. C., Yang, S. H., Tu, Q., & Yin, Y. L. (2018). Glucose and amino acid in enterocyte: absorption, metabolism and maturation. Frontiers in Bioscience, 23, 1721-1739. https://doi.org/10.2741/4669
Cheng, H., & Leblond, C. P. (1974). Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine i. columnar cell. American Journal of Anatomy, 141, 461-479.
De Conto, C., Oevermann, A., Burgener, I. A., Doherr, M. G., & Blum, J. W. (2010). Gastrointestinal tract mucosal histomorphometry and epithelial cell proliferation and apoptosis in neonatal and adult dogs. Journal of Animal Science, 88, 2255-2264. https://doi.org/10.2527/jas.2009-2511
Derouchey, J. M., Hancock, J. D., Hines, R. H., Cummings, K. R., Lee, D. J., & Maloney, C. A. (2003). Effects of dietary electrolyte balance on the chemistry of blood and urine in lactating sows and sow litter performance. Journal of Animal Science, 81, 3067-3074. https://doi.org/10.2527/2003.81123067x
Dersjantli, Y., Verstegen, M. W. A., Jansman, A., Schulze, H., Schrama, J. W., & Verreth, J. A. J. (2002). Changes in oxygen content and acid-base balance in arterial and portal blood in response to the dietary electrolyte balance in pigs during a 9-h period after a meal. Journal of Animal Science, 80, 1233-1239. https://doi.org/10.2527/2002.8051233x
Guzmán-Pino, S. A., Solà-Oriol, D., Davin, R., Manzanilla, E. G., & Pérez, J. F. (2015). Influence of dietary electrolyte balance on feed preference and growth performance of postweaned piglets. Journal of Animal Science, 93, 2840-2848. https://doi.org/10.2527/jas.2014-8380
Hampson, D. J. (1986). Alterations in piglet small intestinal structure at weaning. Research in Veterinary Science, 40, 32-40. https://doi.org/10.1016/S0034-5288(18)30482-X.
Hampson, D. J., & Kidder, D. E. (1986). Influence of creep feeding and weaning on brush border enzyme activities in the piglet small intestine. Research in Veterinary Science, 40, 24-31. https://doi.org/10.1016/S0034-5288(18)30481-8
Haydon, K. D., & West, J. W. (1990). Effect of dietary electrolyte balance on nutrient digestibility determined at the end of the small intestine and over the total digestive tract in growing pigs. Journal of Animal Science, 68, 3687-3693. https://doi.org/10.2527/1990.68113687x
Hedemann, M. S., Hojsgaard, S., & Jensen, B. B. (2003). Small intestinal morphology and activity of intestinal peptidases in piglets around weaning. Journal of Animal Physiology and Animal Nutrition, 87, 32-41. https://doi.org/10.1046/j.1439-0396.2003.00405.x
Henry, R. W., Pickard, D. W., & Hughes, P. E. (2010). Citrcic acid and fumaric acid as food additives for early-weaned piglets. Animal Production, 40, 505-509. https://doi.org/10.1017/S0003356100040204
Heo, J. M., Opapeju, F. O., Pluske, J. R., Kim, J. C., Hampson, D. J., & Nyachoti, C. M. (2012). Gastrointestinal health and function in weaned pigs: a review of feeding strategies to control post-weaning diarrhoea without using in-feed antimicrobial compounds. Journal of Animal Physiology and Animal Nutrition, 97, 207-237. https://doi.org/10.1111/j.1439-0396.2012.01284.x
Hu, C. H., Xiao, K., Luan, Z. S., & Song, J. (2013). Early weaning increases intestinal permeability, alters expression of cytokine and tight junction proteins, and activates mitogen-activated protein kinases in pigs. Journal of Animal Science, 91, 1094-1101. https://doi.org/10.2527/jas.2012-5796
ISO. 6495-1. (2005). Animal feeding stuffs. Determination of water - soluble chlorides content. Part 1:titrimetric method. British Standards Institution. .
Jones, A. M., Wu, F., Woodworth, J. C., Dritz, S. S., Tokach, M. D., DeRouchey, J. M., & Goodband, R. D. (2019). Evaluation of dietary electrolyte balance on nursery pig performance1. Translational Animal Science, 3, 377-383. https://doi.org/10.1093/tas/txy090
Kelly, D., Begbie, R., & King, T. P. (1994). Nutritional influences on interactions between bacteria and the small intestinal mucosa. Nutrition Research Reviews, 7, 233-257. https://doi.org/10.1079/NRR19940013
Kidder, D. E., & Manners, M. J. (1980). The level and distribution of carbohydrases in the small intestine mucosa of pigs from 3 weeks of age to maturity. British Journal of Nutrition, 43, 141-153. https://doi.org/10.1079/bjn19800073
Kumar, S., Suman, S., Fornace, A. J., & Datta, K. (2018). Space radiation triggers persistent stress response, increases senescent signaling, and decreases cell migration in mouse intestine. Proceedings of the National Academy of Sciences, 115, E9832-E9841. https://doi.org/10.1073/pnas.1807522115
Lackeyram, D., Yang, C. B., Archbold, T., Swanson, K. C., & Fan, M. Z. (2010). Early weaning reduces small intestinal alkaline phosphatase expression in pigs. Journal of Nutrition, 140, 461-468. https://doi.org/10.3945/jn.109.117267
Li, Y. L., Ma, S. C., Yang, Y. T., Ye, S. M., & But, P. P. (2002). Antiviral activities of flavonoids and organic acid from Trollius chinensis Bunge. Journal of Ethnopharmacology, 79, 365-368. https://doi.org/10.1016/s0378-8741(01)00410-x
Long, S. F., Xu, Y. T., Pan, L., Wang, Q. Q., Wang, C. L., Wu, J. Y., & Piao, X. S. (2018). Mixed organic acids as antibiotic substitutes improve performance, serum immunity, intestinal morphology and microbiota for weaned piglets. Animal Feed Science and Technology, 235, 23-32. https://doi.org/10.1016/j.anifeedsci.2017.08.018
Lynda, F., Tanushree, B., Neil, P., & Anthony, S. (2018). Acid balance, dietary acid load, and bone effects-a controversial subject. Nutrients, 10, 517-525. https://doi.org/10.3390/nu10040517
Miller, B. G., James, P. S., Smith, M. W., & Bourne, F. J. (1986). Effect of weaning on the capacity of pig intestinal villi to digest and absorb nutrients. Journal of Agricultural Science, 107, 579-590. https://doi.org/10.1017/s0021859600069756
Moeser, A. J., Klok, C. V., Ryan, K. A., Wooten, J. G., Little, D., Cook, V. L., & Blikslager, A. T. (2007). Stress signaling pathways activated by weaning mediate intestinal dysfunction in the pig. American Journal of Physiology-Gastrointestinal and Liver Physiology, 292, G173-G181. https://doi.org/10.1152/ajpgi.00197.2006.
Mongin, P. (1981). Recent advances in dietary anion-cation balance: applications in poultry. Proceedings of the Nutrition Society, 40, 285-294. https://doi.org/10.1079/pns19810045
Namkung, H., Li, M., Gong, J., Yu, H., Cottrill, M., & Cfm, D. L. (2004). Impact of feeding blends of organic acids and herbal extracts on growth performance, gut microbiota and digestive function in newly weaned pigs. Canadian Journal of Animal Science, 84, 697-704. https://doi.org/10.4141/a04-005
NRC (2012). Nutrient requirements of swine, 11th revised edition. National Academy Press.
Patience, J. F., Austic, R. E., & Boyd, R. D. (1987). Effect of dietary electrolyte balance on growth and acid-base status in swine. Journal of Animal Science, 64, 457-466. https://doi.org/10.2527/jas1987.642457x
Patience, J. F., & Chaplin, R. K. (1997). The relationship among dietary undetermined anion, acid-base balance, and nutrient metabolism in swine. Journal of Animal Science, 75, 2445-2452. https://doi.org/10.2527/1997.7592445x
Pluske, J. R., Hampson, D. J., & Williams, I. H. (1997). Factors influencing the structure and function of the small intestine in the weaned pig: a review. Livestock Production Science, 51, 215-236. https://doi.org/10.1016/S0301-6226(97)00057-2
Radcliffe, J. S., Zhang, Z., & Kornegay, E. T. (1998). The effects of microbial phytase, citric acid, and their interaction in a corn-soybean meal-based diet for weanling pigs. Journal of Animal Science, 76, 1880-1886. https://doi.org/10.2527/1998.7671880x
Radecki, S. V., Juhl, M. R., & Miller, E. R. (1988). Fumaric and citric acids as feed additives in starter pig diets: effect on performance and nutrient balance. Journal of Animal Science, 66, 2598-2605. https://doi.org/10.2527/jas1988.66102598x
Risley, C. R., Kornegay, E. T., Lindemann, M. D., & Weakland, S. M. (1991). Effects of organic acids with and without a microbial culture on performance and gastrointestinal tract measurements of weanling pigs. Animal Feed Science and Technology, 35, 259-270. https://doi.org/10.1016/0377-8401(91)90132-C
Seifter, J. L., & Chang, H. Y. (2017). Disorders of acid-base balance: new perspectives. Kidney Disease, 2, 170-186. https://doi.org/10.1159/000453028
Stokes, C. R. (2017). The development and role of microbial-host interactions in gut mucosal immune development. Journal of Animal Science and Biotechnology, 8, 1-12. https://doi.org/10.1186/s40104-016-0138-0
Tonel, I., Pinho, M., Lordelo, M. M., Cunha, L. F., Garres, P., & Freire, J. P. B. (2010). Effect of butyrate on gut development and intestinal mucosa morphology of piglets. Livestock Science, 133, 222-224. https://doi.org/10.1016/j.livsci.2010.06.069
Tsiloyiannis, V. K., Kyriakis, S. C., Vlemmas, J., & Sarris, K. (2001). The effect of organic acids on the control of porcine post-weaning diarrhea. Research in Veterinary Science, 70, 287-293. https://doi.org/10.1053/rvsc.2001.0476
Tsukahara, T., Inoue, R., Nakatani, M., Fukuta, K., Kishino, E., Ito, T., & Ushida, K. (2016). Influence of weaning age on the villus height and disaccharidase activities in the porcine small intestine. Animal Science Journal, 87, 67-75. https://doi.org/10.1111/asj.12399
Walia, K., Argüello, H., Lynch, H., Leonard, F. C., Grant, J., Yearsley, D., & Lawlor, P. G. (2016). Effect of strategic administration of an encapsulated blend of formic acid, citric acid, and essential oils on Salmonella carriage, seroprevalence, and growth of finishing pigs. Preventive Veterinary Medicine, 137, 28-35. https://doi.org/10.1016/j.prevetmed.2016.12.007
Wang, L. X., Yan, S. L., Li, J. Z., Li, Y. L., Ding, X. Q., Yang, S. H., & Yin, Y. L. (2019). Rapid communication: the relationship of enterocyte proliferation with intestinal morphology and nutrient digestibility in weaning piglets. Journal of Animal Science, 97, 353-358. https://doi.org/10.1093/jas/sky388
Xin, J. L., Jing, Y. C., Park, J. H., & Kim, I. H. (2017). Evaluation of different dietary electrolyte balance in weanling pigs diets. Animal Feed Science and Technology, 226, 98-102. https://doi.org/10.1016/j.anifeedsci.2017.02.014