Pituitary stem cells produce paracrine WNT signals to control the expansion of their descendant progenitor cells.
SOX2
WNT
feedforward regulation
mouse
paracrine signal
pituitary gland
regenerative medicine
stem cell
stem cells
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
05 01 2021
05 01 2021
Historique:
received:
20
05
2020
accepted:
04
01
2021
pubmed:
6
1
2021
medline:
19
2
2022
entrez:
5
1
2021
Statut:
epublish
Résumé
In response to physiological demand, the pituitary gland generates new hormone-secreting cells from committed progenitor cells throughout life. It remains unclear to what extent pituitary stem cells (PSCs), which uniquely express SOX2, contribute to pituitary growth and renewal. Moreover, neither the signals that drive proliferation nor their sources have been elucidated. We have used genetic approaches in the mouse, showing that the WNT pathway is essential for proliferation of all lineages in the gland. We reveal that SOX2
Identifiants
pubmed: 33399538
doi: 10.7554/eLife.59142
pii: 59142
pmc: PMC7803373
doi:
pii:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical Research Council
ID : MR/L016729/1
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : K08 DK101603
Pays : United States
Organisme : Wellcome Trust
ID : 090532/Z/09/Z
Pays : United Kingdom
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : Department of Health
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/T012153/1
Pays : United Kingdom
Informations de copyright
© 2021, Russell et al.
Déclaration de conflit d'intérêts
JR, XL, AS, VY, YK, BW, MF, SH, AG, SH, EL, AP, AS, PM, CA No competing interests declared, RN Reviewing editor, eLife
Références
Stem Cells Dev. 2012 Mar 20;21(5):801-13
pubmed: 21970375
J Endocrinol. 2019 Feb 1;240(2):287-308
pubmed: 30475227
Endocrinology. 2016 Feb;157(2):705-21
pubmed: 26653762
Endocr Rev. 2011 Aug;32(4):453-71
pubmed: 21493869
Nat Methods. 2012 Jun 28;9(7):676-82
pubmed: 22743772
Genes Dev. 2016 Jun 15;30(12):1389-94
pubmed: 27313319
Cell Tissue Res. 1990 Aug;261(2):333-8
pubmed: 2401005
Okajimas Folia Anat Jpn. 2000 Mar;76(6):291-301
pubmed: 10774227
Front Physiol. 2016 Mar 31;7:114
pubmed: 27065882
Cell. 2014 Jul 3;158(1):157-70
pubmed: 24976009
Bioinformatics. 2012 Aug 15;28(16):2184-5
pubmed: 22743226
Elife. 2016 Jun 28;5:
pubmed: 27351100
Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):12218-12223
pubmed: 30404917
Elife. 2021 Jan 05;10:
pubmed: 33399538
Bioinformatics. 2014 Apr 1;30(7):923-30
pubmed: 24227677
Dev Neurosci. 2004 Mar-Aug;26(2-4):148-65
pubmed: 15711057
Development. 2017 Jun 15;144(12):2141-2152
pubmed: 28506993
Hum Mutat. 2011 Dec;32(12):1376-80
pubmed: 21919124
Annu Rev Biochem. 2018 Jun 20;87:1015-1027
pubmed: 29494240
Cell Tissue Res. 2017 Oct;370(1):99-112
pubmed: 28660300
Anat Embryol (Berl). 2002 Dec;206(1-2):67-72
pubmed: 12478369
Dev Dyn. 2008 Apr;237(4):1006-20
pubmed: 18351662
J Clin Endocrinol Metab. 2008 May;93(5):1865-73
pubmed: 18285410
Nat Protoc. 2012 Mar 01;7(3):562-78
pubmed: 22383036
Development. 2005 Jan;132(2):335-44
pubmed: 15604099
Genome Biol. 2014;15(12):550
pubmed: 25516281
Nucleic Acids Res. 2016 Jul 8;44(W1):W3-W10
pubmed: 27137889
Cell Tissue Res. 2017 Aug;369(2):353-368
pubmed: 28364143
Endocrinology. 2017 Oct 1;158(10):3339-3353
pubmed: 28938441
Science. 2007 Feb 16;315(5814):988-92
pubmed: 17303754
Bioinformatics. 2010 Jul 15;26(14):1783-5
pubmed: 20562416
Genome Biol. 2010;11(8):R86
pubmed: 20738864
Elife. 2019 Mar 26;8:
pubmed: 30912742
Blood Cells. 1978;4(1-2):7-25
pubmed: 747780
Nature. 2017 May 11;545(7653):238-242
pubmed: 28467820
Science. 2013 Dec 6;342(6163):1226-30
pubmed: 24311688
Dev Biol. 2011 Apr 15;352(2):215-27
pubmed: 21262217
Stem Cell Reports. 2015 Dec 8;5(6):1196-1209
pubmed: 26651607
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Nat Commun. 2017 Nov 28;8(1):1819
pubmed: 29180744
Science. 2014 Mar 21;343(6177):1353-6
pubmed: 24653033
Cell Stem Cell. 2012 Sep 7;11(3):387-400
pubmed: 22863533
Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):E1489-97
pubmed: 26929341
Acta Neuropathol. 2012 Aug;124(2):259-71
pubmed: 22349813
Cell Stem Cell. 2016 Dec 1;19(6):686-689
pubmed: 27912089
Mol Cell Biol. 2009 Apr;29(7):1895-908
pubmed: 19139274
Nature. 2015 Jul 30;523(7562):597-601
pubmed: 26147083
Sci Rep. 2017 Dec 5;7(1):16940
pubmed: 29208952
Endocr Relat Cancer. 2019 Jan 1;26(1):215-225
pubmed: 30139767
Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2907-12
pubmed: 18287078
Nature. 2015 Oct 29;526(7575):715-8
pubmed: 26503053
BMC Dev Biol. 2010 Dec 21;10:121
pubmed: 21176145
Genes Dev. 2019 Feb 1;33(3-4):209-220
pubmed: 30692207
Nat Methods. 2015 Apr;12(4):357-60
pubmed: 25751142
Trends Neurosci. 2003 Jul;26(7):351-9
pubmed: 12850431
Cell Stem Cell. 2011 Oct 4;9(4):317-29
pubmed: 21982232
Nature. 2013 Jul 11;499(7457):228-32
pubmed: 23760480
Cell Stem Cell. 2013 Oct 3;13(4):419-32
pubmed: 24094323
Cell Tissue Res. 2015 Mar;359(3):755-66
pubmed: 25480420
Nature. 2015 Aug 13;524(7564):180-5
pubmed: 26245375
Cell Stem Cell. 2013 Oct 3;13(4):433-45
pubmed: 24094324
Stem Cells. 2017 Jun;35(6):1566-1578
pubmed: 28370670
Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11482-7
pubmed: 21636786
Cell Rep. 2016 Aug 16;16(7):1929-41
pubmed: 27498859
Cell Stem Cell. 2020 Jan 2;26(1):64-80.e13
pubmed: 31883834
Curr Top Dev Biol. 2014;107:77-107
pubmed: 24439803
Genesis. 2010 Sep;48(9):554-8
pubmed: 20614471
Science. 2018 Mar 9;359(6380):1118-1123
pubmed: 29420258