The effect of acute sleep deprivation on skeletal muscle protein synthesis and the hormonal environment.
hormones
muscle
muscle protein synthesis
sleep deprivation
Journal
Physiological reports
ISSN: 2051-817X
Titre abrégé: Physiol Rep
Pays: United States
ID NLM: 101607800
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
03
11
2020
accepted:
08
11
2020
entrez:
5
1
2021
pubmed:
6
1
2021
medline:
22
12
2021
Statut:
ppublish
Résumé
Chronic sleep loss is a potent catabolic stressor, increasing the risk of metabolic dysfunction and loss of muscle mass and function. To provide mechanistic insight into these clinical outcomes, we sought to determine if acute sleep deprivation blunts skeletal muscle protein synthesis and promotes a catabolic environment. Healthy young adults (N = 13; seven male, six female) were subjected to one night of total sleep deprivation (DEP) and normal sleep (CON) in a randomized cross-over design. Anabolic and catabolic hormonal profiles were assessed across the following day. Postprandial muscle protein fractional synthesis rate (FSR) was assessed between 13:00 and 15:00 and gene markers of muscle protein degradation were assessed at 13:00. Acute sleep deprivation reduced muscle protein synthesis by 18% (CON: 0.072 ± 0.015% vs. DEP: 0.059 ± 0.014%·h
Identifiants
pubmed: 33400856
doi: 10.14814/phy2.14660
pmc: PMC7785053
doi:
Substances chimiques
Muscle Proteins
0
Testosterone
3XMK78S47O
Hydrocortisone
WI4X0X7BPJ
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14660Informations de copyright
© 2021 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.
Références
Am J Physiol. 1987 May;252(5 Pt 1):E621-6
pubmed: 3578511
Nutr Metab (Lond). 2013 Jan 25;10(1):15
pubmed: 23351781
Med Sci Sports Exerc. 2020 Feb;52(2):507-514
pubmed: 31469710
Sports Med. 2010 Dec 1;40(12):1037-53
pubmed: 21058750
JAMA. 2011 Jun 1;305(21):2173-4
pubmed: 21632481
Am J Physiol. 1995 Nov;269(5 Pt 1):E820-6
pubmed: 7491931
Nutrients. 2017 Mar 08;9(3):
pubmed: 28282858
J Physiol. 2009 Jan 15;587(1):211-7
pubmed: 19001042
J Biol Rhythms. 2015 Apr;30(2):84-94
pubmed: 25512305
J Clin Endocrinol Metab. 1999 Aug;84(8):2705-11
pubmed: 10443664
PLoS One. 2012;7(7):e41218
pubmed: 22844441
Am J Physiol Endocrinol Metab. 2007 Sep;293(3):E833-42
pubmed: 17609259
J Clin Endocrinol Metab. 2019 May 1;104(5):1687-1696
pubmed: 30535338
Am J Clin Nutr. 2016 Feb;103(2):465-73
pubmed: 26718415
J Clin Endocrinol Metab. 2005 Aug;90(8):4530-5
pubmed: 15914523
Psychoneuroendocrinology. 2009 Apr;34(3):455-62
pubmed: 19038501
BMJ. 2016 Nov 1;355:i5210
pubmed: 27803010
J Physiol. 2020 Apr;598(8):1523-1536
pubmed: 32078168
Ageing Res Rev. 2015 Sep;23(Pt B):210-20
pubmed: 26216211
Sleep. 2003 May 1;26(3):342-92
pubmed: 12749557
Am J Physiol Endocrinol Metab. 2003 May;284(5):E946-53
pubmed: 12569085
J Clin Endocrinol Metab. 2006 Dec;91(12):4836-41
pubmed: 16984982
Muscle Nerve. 2012 Mar;45(3):431-3
pubmed: 22334180
Diabetes. 2010 Sep;59(9):2126-33
pubmed: 20585000
Nat Rev Endocrinol. 2019 Jul;15(7):393-405
pubmed: 31073218
Nutr Metab (Lond). 2019 Aug 22;16:56
pubmed: 31440303
Sleep Med. 2014 Dec;15(12):1456-62
pubmed: 25450058
J Appl Physiol (1985). 2012 Jun;112(11):1805-13
pubmed: 22383503
Am J Physiol Endocrinol Metab. 2006 Jan;290(1):E163-E168
pubmed: 16131512
Endocrinology. 2008 Nov;149(11):5449-60
pubmed: 18599544
J Physiol. 2020 Jun;598(11):2059-2060
pubmed: 32240541
J Nutr. 2014 Jun;144(6):876-80
pubmed: 24477298
Metabolism. 2018 Jul;84:56-66
pubmed: 29510179
Sci Adv. 2018 Aug 22;4(8):eaar8590
pubmed: 30140739
J Nutr. 2013 Mar;143(3):307-14
pubmed: 23343676
Med Hypotheses. 2013 Jun;80(6):701-5
pubmed: 23490203
Int J Chronobiol. 1976;4(2):97-110
pubmed: 1027738
Eur J Appl Physiol. 2005 Oct;95(4):351-60
pubmed: 16151837
Am J Physiol Endocrinol Metab. 2018 Nov 1;315(5):E848-E858
pubmed: 29989853
PLoS One. 2017 May 1;12(5):e0176685
pubmed: 28459884
Clin Exp Pharmacol Physiol. 2010 Mar;37(3):378-84
pubmed: 19650790
J Health Psychol. 2020 Jun;25(7):900-912
pubmed: 29076400
J Clin Endocrinol Metab. 2001 Mar;86(3):1134-9
pubmed: 11238497
FASEB J. 2013 Dec;27(12):5104-11
pubmed: 23965841
Dtsch Arztebl Int. 2016 Apr 15;113(15):253-60
pubmed: 27151463
Sleep Med. 2016 May;21:35-41
pubmed: 27448469
Med Sci Sports Exerc. 2011 Jul;43(7):1154-61
pubmed: 21131864
Amino Acids. 2016 Apr;48(4):949-957
pubmed: 26645537
Eur J Appl Physiol Occup Physiol. 1990;60(4):288-92
pubmed: 2357985
Sports Med. 2019 Nov;49(11):1637-1650
pubmed: 31190324
Br J Pharmacol. 2008 Jun;154(3):557-68
pubmed: 18500379
J Clin Endocrinol Metab. 2015 Sep;100(9):E1255-61
pubmed: 26168277
Acta Physiol (Oxf). 2018 Jun;223(2):e13039
pubmed: 29356345
Front Physiol. 2016 Jul 08;7:292
pubmed: 27458387