Flipping the script: viral capitalization of RNA modifications.
2’-O methylation
N6-methyladenosine
N7-methylguanosine
RNA modifications
RNA viruses
Journal
Briefings in functional genomics
ISSN: 2041-2657
Titre abrégé: Brief Funct Genomics
Pays: England
ID NLM: 101528229
Informations de publication
Date de publication:
27 03 2021
27 03 2021
Historique:
received:
18
09
2020
revised:
01
12
2020
accepted:
03
12
2020
pubmed:
6
1
2021
medline:
26
10
2021
entrez:
5
1
2021
Statut:
ppublish
Résumé
RNA encoded by RNA viruses is highly regulated so that it can function in multiple roles during the viral life cycle. These roles include serving as the mRNA template for translation or the genetic material for replication as well as being packaged into progeny virions. RNA modifications provide an emerging regulatory dimension to the RNA of viruses. Modification of the viral RNA can increase the functional genomic capacity of the RNA viruses without the need to encode and translate additional genes. Further, RNA modifications can facilitate interactions with host or viral RNA-binding proteins that promote replication or can prevent interactions with antiviral RNA-binding proteins. The mechanisms by which RNA viruses facilitate modification of their RNA are diverse. In this review, we discuss some of these mechanisms, including exploring the unknown mechanism by which the RNA of viruses that replicate in the cytoplasm could acquire the RNA modification N6-methyladenosine.
Identifiants
pubmed: 33401298
pii: 6065004
doi: 10.1093/bfgp/elaa025
pmc: PMC8008163
doi:
Substances chimiques
RNA, Messenger
0
RNA, Viral
0
RNA-Binding Proteins
0
Adenosine
K72T3FS567
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
86-93Subventions
Organisme : NIAID NIH HHS
ID : R01 AI125416
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009111
Pays : United States
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
Références
Genes Dev. 2018 Mar 1;32(5-6):415-429
pubmed: 29535189
Cell Res. 2017 Mar;27(3):444-447
pubmed: 28106076
Sci Rep. 2018 Jun 25;8(1):9633
pubmed: 29941893
Cell. 2017 May 18;169(5):824-835.e14
pubmed: 28525753
Mol Cell. 2016 Feb 18;61(4):507-519
pubmed: 26876937
Arch Virol. 1996;141(3-4):525-39
pubmed: 8645093
Virology. 1993 Nov;197(1):265-73
pubmed: 8212562
Virology. 1978 Sep;89(2):423-37
pubmed: 568848
Virology. 2020 Sep;548:59-72
pubmed: 32838947
Nucleic Acids Res. 2018 Sep 6;46(15):7902-7912
pubmed: 30192980
Genes Dev. 1997 Dec 15;11(24):3319-26
pubmed: 9407025
Annu Rev Virol. 2019 Sep 29;6(1):235-253
pubmed: 31283446
Nat Struct Mol Biol. 2008 May;15(5):500-6
pubmed: 18454157
Chem Rev. 2018 Apr 25;118(8):4448-4482
pubmed: 29652486
J Biol Chem. 1976 Aug 25;251(16):5043-53
pubmed: 821947
PLoS Pathog. 2013;9(10):e1003663
pubmed: 24098121
Science. 2016 Jun 17;352(6292):1408-12
pubmed: 27313037
Cell. 1981 Nov;26(3 Pt 1):391-400
pubmed: 7326745
Proc Natl Acad Sci U S A. 1976 Sep;73(9):3045-9
pubmed: 1067600
Cell Res. 2014 Dec;24(12):1493-6
pubmed: 25412661
Nat Rev Immunol. 2016 Sep;16(9):566-80
pubmed: 27455396
Cell Host Microbe. 2016 Nov 9;20(5):654-665
pubmed: 27773535
Cell. 2015 Jun 4;161(6):1388-99
pubmed: 26046440
mSphere. 2020 May 13;5(3):
pubmed: 32404510
J Gen Virol. 1993 Apr;74 ( Pt 4):733-40
pubmed: 8385698
J Virol. 2006 Sep;80(17):8362-70
pubmed: 16912287
Arch Biochem Biophys. 1968 Jul;126(1):8-15
pubmed: 5671075
Nucleic Acids Res. 2019 Jan 10;47(1):362-374
pubmed: 30364964
Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):596-601
pubmed: 26733676
RNA Biol. 2011 Mar-Apr;8(2):270-9
pubmed: 21593585
PLoS Pathog. 2012;8(4):e1002642
pubmed: 22496660
Nat Immunol. 2011 Feb;12(2):137-43
pubmed: 21217758
Nat Commun. 2016 Aug 25;7:12626
pubmed: 27558897
RNA. 2009 Dec;15(12):2340-50
pubmed: 19850911
Cell. 2017 Apr 6;169(2):326-337.e12
pubmed: 28388414
Nature. 2010 Nov 18;468(7322):452-6
pubmed: 21085181
Nature. 2009 Apr 16;458(7240):914-8
pubmed: 19194459
Nat Microbiol. 2020 Apr;5(4):584-598
pubmed: 32015498
Nature. 2005 Feb 3;433(7025):477-80
pubmed: 15690031
Cell Rep. 2015 Jul 28;12(4):562-72
pubmed: 26190105
Biochemistry. 1977 Apr 19;16(8):1672-6
pubmed: 856255
Biochimie. 1994;76(9):831-8
pubmed: 7880899
J Virol. 1978 Oct;28(1):75-83
pubmed: 702657
Nucleic Acids Res. 2018 Jan 4;46(D1):D303-D307
pubmed: 29106616
Proc Natl Acad Sci U S A. 1978 Oct;75(10):4886-90
pubmed: 283399
Proc Natl Acad Sci U S A. 1975 Jan;72(1):318-22
pubmed: 164018
Genes Dev. 1997 Dec 15;11(24):3306-18
pubmed: 9407024
PLoS Pathog. 2012;8(5):e1002698
pubmed: 22589727
J Biol Chem. 1957 Aug;227(2):907-15
pubmed: 13463012
Cell Res. 2014 Feb;24(2):177-89
pubmed: 24407421
Nat Rev Microbiol. 2016 Aug;14(8):479-93
pubmed: 27396566
Mol Cell. 2020 Feb 6;77(3):542-555.e8
pubmed: 31810760
RNA. 2018 Apr;24(4):499-512
pubmed: 29348140
Proc Natl Acad Sci U S A. 1981 Jan;78(1):187-91
pubmed: 6264433
Wiley Interdiscip Rev RNA. 2019 Sep;10(5):e1536
pubmed: 31034160
RNA. 1997 Nov;3(11):1233-47
pubmed: 9409616
Nucleic Acids Res. 2016 Sep 19;44(16):7511-26
pubmed: 27317694
Nat Rev Microbiol. 2007 Jun;5(6):453-63
pubmed: 17487147
Nucleic Acids Res. 2018 Jun 20;46(11):5776-5791
pubmed: 29373715
J Am Chem Soc. 2019 Dec 26;141(51):19988-19993
pubmed: 31826614
Nat Chem Biol. 2014 Feb;10(2):93-5
pubmed: 24316715
Science. 2014 Feb 14;343(6172):783-7
pubmed: 24482115
Biochim Biophys Acta. 1969 Oct 22;190(2):264-73
pubmed: 4900574
Wiley Interdiscip Rev RNA. 2021 Jan;12(1):e1618
pubmed: 32686365
Biochem Biophys Res Commun. 2008 Aug 8;372(4):719-24
pubmed: 18533109
Nat Chem Biol. 2011 Oct 16;7(12):885-7
pubmed: 22002720
Cell. 1975 Apr;4(4):379-86
pubmed: 164293
Trends Microbiol. 2003 Dec;11(12):543-6
pubmed: 14659685
Nat Rev Microbiol. 2009 Jun;7(6):439-50
pubmed: 19430490
J Virol. 1992 Mar;66(3):1476-83
pubmed: 1310759
Nat Commun. 2019 Jul 30;10(1):3401
pubmed: 31363086
J Mol Biol. 1977 Jun 15;113(1):165-79
pubmed: 196091
Nucleic Acids Res. 2019 Sep 5;47(15):7719-7733
pubmed: 31328227
Virology. 1976 Jul 15;72(2):341-51
pubmed: 948865
Virology. 1979 Jul 15;96(1):159-65
pubmed: 111410
Cell Res. 2017 Mar;27(3):315-328
pubmed: 28106072
Nature. 2012 Apr 29;485(7397):201-6
pubmed: 22575960
J Virol. 1976 Oct;20(1):45-53
pubmed: 1086370
Mol Cell. 2013 Jan 10;49(1):18-29
pubmed: 23177736
Nat Rev Microbiol. 2011 Dec 05;10(1):51-65
pubmed: 22138959
Cell. 2017 May 4;169(4):679-692.e14
pubmed: 28475896
Cell. 2012 Jun 22;149(7):1635-46
pubmed: 22608085
EMBO J. 2002 Jun 3;21(11):2757-68
pubmed: 12032088
RNA. 2015 Dec;21(12):2067-75
pubmed: 26428694
J Biol Chem. 2010 Oct 22;285(43):33037-33044
pubmed: 20713356
Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10104-8
pubmed: 21636784
Nature. 2019 Jan;565(7740):500-504
pubmed: 30626973
Virology. 2017 Sep;509:167-177
pubmed: 28646652
Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7029-36
pubmed: 11416183
Nature. 2015 Feb 26;518(7540):560-4
pubmed: 25719671
Nature. 2014 Jan 2;505(7481):117-20
pubmed: 24284625
Proc Natl Acad Sci U S A. 1979 Apr;76(4):1618-22
pubmed: 287003
J Virol. 2007 Apr;81(8):3891-903
pubmed: 17267492