Hemolysis at low blood flow rates: in-vitro and in-silico evaluation of a centrifugal blood pump.
Centrifugal blood pumps
ECCO2R
ECMO
Extracorporeal circulation
Hemolysis
Off-design point
Pediatric patients
Journal
Journal of translational medicine
ISSN: 1479-5876
Titre abrégé: J Transl Med
Pays: England
ID NLM: 101190741
Informations de publication
Date de publication:
05 01 2021
05 01 2021
Historique:
received:
14
07
2020
accepted:
30
10
2020
entrez:
6
1
2021
pubmed:
7
1
2021
medline:
15
5
2021
Statut:
epublish
Résumé
Treating severe forms of the acute respiratory distress syndrome and cardiac failure, extracorporeal membrane oxygenation (ECMO) has become an established therapeutic option. Neonatal or pediatric patients receiving ECMO, and patients undergoing extracorporeal CO In this study, the hemolysis of the centrifugal pump DP3 is evaluated both in vitro and in silico, comparing the low-flow operation at 1 L/min to the high-flow operation at 4 L/min. Increased hemolysis occurs at low-flow, both in vitro and in silico. The in-vitro experiments present a sixfold higher relative increased hemolysis at low-flow. Compared to high-flow operation, a more than 3.5-fold increase in blood recirculation within the pump head can be observed in the low-flow range in silico. This study highlights the underappreciated hemolysis in centrifugal pumps within the low-flow range, i.e. during pediatric ECMO or ECCO
Sections du résumé
BACKGROUND
Treating severe forms of the acute respiratory distress syndrome and cardiac failure, extracorporeal membrane oxygenation (ECMO) has become an established therapeutic option. Neonatal or pediatric patients receiving ECMO, and patients undergoing extracorporeal CO
METHODS
In this study, the hemolysis of the centrifugal pump DP3 is evaluated both in vitro and in silico, comparing the low-flow operation at 1 L/min to the high-flow operation at 4 L/min.
RESULTS
Increased hemolysis occurs at low-flow, both in vitro and in silico. The in-vitro experiments present a sixfold higher relative increased hemolysis at low-flow. Compared to high-flow operation, a more than 3.5-fold increase in blood recirculation within the pump head can be observed in the low-flow range in silico.
CONCLUSIONS
This study highlights the underappreciated hemolysis in centrifugal pumps within the low-flow range, i.e. during pediatric ECMO or ECCO
Identifiants
pubmed: 33402176
doi: 10.1186/s12967-020-02599-z
pii: 10.1186/s12967-020-02599-z
pmc: PMC7784380
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2Références
Dtsch Med Wochenschr. 2013 Feb;138(5):188-91
pubmed: 23340937
Intensive Care Med. 2016 Sep;42(9):1437-44
pubmed: 27456703
Intensive Care Med Exp. 2019 Aug 20;7(1):51
pubmed: 31432279
Pediatr Crit Care Med. 2019 Dec;20(12):1195-1196
pubmed: 31804441
Biorheology. 1994 Sep-Oct;31(5):565-86
pubmed: 7833458
ASAIO J. 2012 Jul-Aug;58(4):363-72
pubmed: 22635012
Biotechnol J. 2020 Apr;15(4):e1900239
pubmed: 31904165
J Biomech Eng. 2012 Aug;134(8):081002
pubmed: 22938355
Thromb Res. 1998 Dec 15;92(6 Suppl 2):S33-41
pubmed: 9886908
Crit Care. 2019 Nov 6;23(1):348
pubmed: 31694688
Lancet Respir Med. 2020 Nov;8(11):1121-1131
pubmed: 32798468
Blood. 2015 Nov 12;126(20):2338-41
pubmed: 26307534
J Thorac Cardiovasc Surg. 2020 Apr;159(4):1519-1527.e1
pubmed: 31444074
Pediatr Crit Care Med. 2019 Dec;20(12):1177-1184
pubmed: 31567621
ASAIO J. 2011 Nov-Dec;57(6):516-21
pubmed: 21989419
Intensive Care Med. 2019 May;45(5):592-600
pubmed: 30790030
JAMA. 2019 Aug 13;322(6):557-568
pubmed: 31408142
J Clin Pathol. 1996 Apr;49(4):271-4
pubmed: 8655699
J Biomech Eng. 2018 Nov 20;:
pubmed: 30458464
PLoS One. 2015 Apr 22;10(4):e0124034
pubmed: 25902047
J Extra Corpor Technol. 2014 Sep;46(3):217-23
pubmed: 26357787
ASAIO J. 2007 Jan-Feb;53(1):23-31
pubmed: 17237645
Crit Care. 2019 Apr 23;23(1):135
pubmed: 31014366
Trans Am Soc Artif Intern Organs. 1975;21:35-9
pubmed: 1146007
Ann Transl Med. 2019 Oct;7(19):512
pubmed: 31728365
Biophys Chem. 2010 Dec;153(1):1-8
pubmed: 20797815
ASAIO J. 2015 Sep-Oct;61(5):496-501
pubmed: 25914954
JAMA. 2018 Dec 4;320(21):2251-2259
pubmed: 30347031
Artif Organs. 2007 Sep;31(9):677-88
pubmed: 17725695
Circ Res. 1977 Jul;41(1):2-8
pubmed: 324656
Cardiovasc Eng Technol. 2011 Dec 1;2(4):263-275
pubmed: 23494160
Perfusion. 2016 Nov;31(8):662-667
pubmed: 27272509