P-glycoprotein induction and its energetic costs in rainbow trout (Oncorhynchus mykiss).
14-alpha Demethylase Inhibitors
/ pharmacology
ATP Binding Cassette Transporter, Subfamily B, Member 1
/ genetics
Animals
Cell Survival
/ drug effects
Clotrimazole
/ pharmacology
Energy Metabolism
/ physiology
Gene Expression Regulation
/ drug effects
Hepatocytes
/ drug effects
Oncorhynchus mykiss
/ metabolism
Oxygen Consumption
Energetic costs
Fish
Induction
Oxygen consumption
P-glycoprotein
Rainbow trout
Respiration
Journal
Fish physiology and biochemistry
ISSN: 1573-5168
Titre abrégé: Fish Physiol Biochem
Pays: Netherlands
ID NLM: 100955049
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
20
10
2020
accepted:
26
11
2020
pubmed:
7
1
2021
medline:
27
7
2021
entrez:
6
1
2021
Statut:
ppublish
Résumé
Biological organisms are constantly challenged by xenobiotics and have evolved mechanisms to reduce, neutralize, or repair toxic outcomes. The various chemical defenses all utilize energy, but their specific costs and impacts on energy budgets are currently unknown. In this study, the energetic costs associated with the induction and substrate transport of the efflux transporter P-glycoprotein (P-gp [ABCB1, MDR1]) were examined in rainbow trout. An intraperitoneal injection of the P-gp inducer clotrimazole (0, 0.1, 1.0, and 10 mg/kg) increased P-gp activity (as measured by a competitive rhodamine 123 transport assay in hepatocytes) in a dose-dependent manner reaching a maximum induction of 2.8-fold. Maximum P-gp induction occurred at 50 h post-administration with the highest dose; significant induction of P-gp activity remained elevated over constitutive values until the last sampling time point (168 h). In vitro measurements of hepatocyte respiration indicated that basal P-gp activity transporting R123 as a substrate did not significantly increase respiration rates (range 18.0 to 23.2 ng O
Identifiants
pubmed: 33405060
doi: 10.1007/s10695-020-00911-8
pii: 10.1007/s10695-020-00911-8
doi:
Substances chimiques
14-alpha Demethylase Inhibitors
0
ATP Binding Cassette Transporter, Subfamily B, Member 1
0
Clotrimazole
G07GZ97H65
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
265-279Subventions
Organisme : Natural Sciences and Engineering Research Council of Canada
ID : R611305
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