AICAR and compound C negatively modulate HCC-induced primary human hepatic stellate cell activation in vitro.
AMP-Activated Protein Kinases
/ antagonists & inhibitors
Aminoimidazole Carboxamide
/ analogs & derivatives
Animals
Carcinoma, Hepatocellular
/ drug therapy
Cell Proliferation
/ drug effects
Culture Media, Conditioned
Databases, Genetic
Enzyme Activation
Enzyme Activators
/ pharmacology
Hep G2 Cells
Hepatic Stellate Cells
/ drug effects
Humans
Liver Neoplasms
/ drug therapy
Mutation
Paracrine Communication
Phosphorylation
Protein Kinase Inhibitors
/ pharmacology
Pyrazoles
/ pharmacology
Pyrimidines
/ pharmacology
Ribonucleotides
/ pharmacology
Signal Transduction
Tumor Microenvironment
Tumor Suppressor Protein p53
/ genetics
beta Catenin
/ genetics
LICA-FR
TCGA
adenosine monophosphate-activated kinase
hepatic stellate cells
hepatocellular carcinoma
liver fibrosis
tumor-stromal interactions
Journal
American journal of physiology. Gastrointestinal and liver physiology
ISSN: 1522-1547
Titre abrégé: Am J Physiol Gastrointest Liver Physiol
Pays: United States
ID NLM: 100901227
Informations de publication
Date de publication:
01 04 2021
01 04 2021
Historique:
pubmed:
7
1
2021
medline:
11
5
2021
entrez:
6
1
2021
Statut:
ppublish
Résumé
Tumor stroma and microenvironment have been shown to affect hepatocellular carcinoma (HCC) growth, with activated hepatic stellate cells (HSC) as a major contributor in this process. Recent evidence suggests that the energy sensor adenosine monophosphate-activated kinase (AMPK) may mediate a series of essential processes during carcinogenesis and HCC progression. Here, we investigated the effect of different HCC cell lines with known
Identifiants
pubmed: 33406006
doi: 10.1152/ajpgi.00262.2020
doi:
Substances chimiques
CTNNB1 protein, human
0
Culture Media, Conditioned
0
Enzyme Activators
0
Protein Kinase Inhibitors
0
Pyrazoles
0
Pyrimidines
0
Ribonucleotides
0
TP53 protein, human
0
Tumor Suppressor Protein p53
0
beta Catenin
0
dorsomorphin
10K52CIC1Z
Aminoimidazole Carboxamide
360-97-4
AMPK alpha1 subunit, mouse
EC 2.7.11.1
AMPK alpha2 subunit, mouse
EC 2.7.11.1
PRKAA2 protein, human
EC 2.7.11.1
AMP-Activated Protein Kinases
EC 2.7.11.31
PRKAA1 protein, human
EC 2.7.11.31
AICA ribonucleotide
F0X88YW0YK
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM