Acute acetate administration increases endogenous opioid levels in the human brain: A [
Acetate
PET
opioid
Journal
Journal of psychopharmacology (Oxford, England)
ISSN: 1461-7285
Titre abrégé: J Psychopharmacol
Pays: United States
ID NLM: 8907828
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
pubmed:
8
1
2021
medline:
20
1
2022
entrez:
7
1
2021
Statut:
ppublish
Résumé
A recent study has shown that acetate administration leads to a fourfold increase in the transcription of proopiomelanocortin (POMC) mRNA in the hypothalamus. POMC is cleaved to peptides, including β-endorphin, an endogenous opioid (EO) agonist that binds preferentially to the µ-opioid receptor (MOR). We hypothesised that an acetate challenge would increase the levels of EO in the human brain. We have previously demonstrated that increased EO release in the human brain can be detected using positron emission tomography (PET) with the selective MOR radioligand [ Seven volunteers each completed a baseline [ Following sodium acetate administration, 2.5-6.5% reductions in [ We have demonstrated that an acute acetate challenge has the potential to increase EO release in the human brain, providing a plausible mechanism of the central effects of acetate on appetite in humans.
Identifiants
pubmed: 33406950
doi: 10.1177/0269881120965912
pmc: PMC8155733
doi:
Substances chimiques
Analgesics, Opioid
0
Carbon Radioisotopes
0
Opioid Peptides
0
Receptors, Opioid
0
Sodium Acetate
4550K0SC9B
carfentanil
LA9DTA2L8F
Fentanyl
UF599785JZ
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
606-610Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_U120097115
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N00616X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N027078/1
Pays : United Kingdom
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