Cariprazine modulates sleep architecture in rats.
Dopamine receptor partial agonist
Sprague Dawley rats
clinical efficacy
depressive state
rapid eye movement REM sleep
Journal
Journal of psychopharmacology (Oxford, England)
ISSN: 1461-7285
Titre abrégé: J Psychopharmacol
Pays: United States
ID NLM: 8907828
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
pubmed:
8
1
2021
medline:
24
11
2021
entrez:
7
1
2021
Statut:
ppublish
Résumé
Cariprazine is a dopamine D This study examined the acute systemic effects of cariprazine on the rat sleep architecture and electroencephalography spectral power. Sprague Dawley rats were recorded during their normal sleep period for four hours, and their sleep stages were classified. Cariprazine (0.3 mg/kg i.p.) reduced the time spent in rapid eye movement (REM) sleep and increased REM latency. This dose of cariprazine decreased the gamma (40-80 Hz) band frequency oscillations and increased the theta (4-9 Hz) and alpha (9-15 Hz) frequencies during the wake periods but not during slow-wave sleep. The 0.03 mg/kg dose of cariprazine only increased the alpha power during the wake periods, while the 0.003 mg/kg dose was without any effect. Taken together, the present results suggest that the REM-suppressing effect of cariprazine may be related to its effectiveness in improving depressive symptoms, as various drugs with similar REM-reducing properties effectively treat the depressive state, whereas the gamma power-reducing effect of cariprazine may be indicative of its efficacy in schizophrenia or mania, as similar effects have been observed with other D
Sections du résumé
BACKGROUND
Cariprazine is a dopamine D
AIMS
This study examined the acute systemic effects of cariprazine on the rat sleep architecture and electroencephalography spectral power.
METHODS
Sprague Dawley rats were recorded during their normal sleep period for four hours, and their sleep stages were classified.
RESULTS
Cariprazine (0.3 mg/kg i.p.) reduced the time spent in rapid eye movement (REM) sleep and increased REM latency. This dose of cariprazine decreased the gamma (40-80 Hz) band frequency oscillations and increased the theta (4-9 Hz) and alpha (9-15 Hz) frequencies during the wake periods but not during slow-wave sleep. The 0.03 mg/kg dose of cariprazine only increased the alpha power during the wake periods, while the 0.003 mg/kg dose was without any effect.
CONCLUSION
Taken together, the present results suggest that the REM-suppressing effect of cariprazine may be related to its effectiveness in improving depressive symptoms, as various drugs with similar REM-reducing properties effectively treat the depressive state, whereas the gamma power-reducing effect of cariprazine may be indicative of its efficacy in schizophrenia or mania, as similar effects have been observed with other D
Identifiants
pubmed: 33406962
doi: 10.1177/0269881120981378
doi:
Substances chimiques
Antipsychotic Agents
0
Dopamine Agonists
0
Piperazines
0
cariprazine
F6RJL8B278
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM