Are Physicochemical Properties Shaping the Allergenic Potency of Animal Allergens?

Allergen integrity Allergenicity Animal allergens Food processing Protein families

Journal

Clinical reviews in allergy & immunology
ISSN: 1559-0267
Titre abrégé: Clin Rev Allergy Immunol
Pays: United States
ID NLM: 9504368

Informations de publication

Date de publication:
Feb 2022
Historique:
accepted: 09 11 2020
pubmed: 8 1 2021
medline: 7 4 2022
entrez: 7 1 2021
Statut: ppublish

Résumé

Key determinants for the development of an allergic response to an otherwise 'harmless' food protein involve different factors like the predisposition of the individual, the timing, the dose, the route of exposure, the intrinsic properties of the allergen, the food matrix (e.g. lipids) and the allergen modification by food processing. Various physicochemical parameters can have an impact on the allergenicity of animal proteins. Following our previous review on how physicochemical parameters shape plant protein allergenicity, the same analysis was proceeded here for animal allergens. We found that each parameter can have variable effects, ranging on an axis from allergenicity enhancement to resolution, depending on its nature and the allergen. While glycosylation and phosphorylation are common, both are not universal traits of animal allergens. High molecular structures can favour allergenicity, but structural loss and uncovering hidden epitopes can also have a similar impact. We discovered that there are important knowledge gaps in regard to physicochemical parameters shaping protein allergenicity both from animal and plant origin, mainly because the comparability of the data is poor. Future biomolecular studies of exhaustive, standardised design together with strong validation part in the clinical context, together with data integration model systems will be needed to unravel causal relationships between physicochemical properties and the basis of protein allergenicity.

Identifiants

pubmed: 33411319
doi: 10.1007/s12016-020-08826-1
pii: 10.1007/s12016-020-08826-1
doi:

Substances chimiques

Allergens 0
Epitopes 0
Proteins 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1-36

Subventions

Organisme : European Cooperation in Science and Technology
ID : COST Action FA1402 (ImpARAS)
Organisme : Fundação para a Ciência e a Tecnologia
ID : PTDC/BAA-AGR/31720/2017
Organisme : Fundação para a Ciência e a Tecnologia
ID : UIDB 50006/2020
Organisme : Fundação para a Ciência e a Tecnologia
ID : PD/BD/114576/2016
Organisme : Fundação para a Ciência e a Tecnologia
ID : UIDB/04326/2020
Organisme : Fundação para a Ciência e a Tecnologia
ID : Mar2020 16-02-01-FMP-0014
Organisme : Ministry of Education, Science and Technological Development of the Republic of Serbia
ID : OI172024
Organisme : Fonds National de la Recherche
ID : PRIDE/11012546/NEXTIMMUNE
Organisme : Fundação para a Ciência e a Tecnologia
ID : SFRH/BPD/102404/2014

Informations de copyright

© 2021. Springer Science+Business Media, LLC, part of Springer Nature.

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Auteurs

Joana Costa (J)

REQUIMTE-LAQV/Faculdade de Farmácia, Universidade Do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313, Porto, Portugal. jbcosta@ff.up.pt.

Caterina Villa (C)

REQUIMTE-LAQV/Faculdade de Farmácia, Universidade Do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313, Porto, Portugal.

Kitty Verhoeckx (K)

Department of Dermatology/Allergology, University Medical Center Utrecht, Utrecht, The Netherlands.

Tanja Cirkovic-Velickovic (T)

Faculty of Chemistry, University of Belgrade, Belgrade, Serbia.
Ghent University Global Campus, Yeonsu-gu, Incheon, South Korea.
Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium.

Denise Schrama (D)

CCMAR, Universidade Do Algarve, Campus de Gambelas, Faro, Portugal.

Paola Roncada (P)

Department of Health Sciences, University 'Magna Græcia', Catanzaro, Italy.

Pedro M Rodrigues (PM)

CCMAR, Universidade Do Algarve, Campus de Gambelas, Faro, Portugal.

Cristian Piras (C)

Department of Veterinary Medicine, University of Milan, Milan, Italy.
Department of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK.

Laura Martín-Pedraza (L)

Biochemistry and Molecular Biology Department, Chemistry Faculty, Complutense University of Madrid, 28040, Madrid, Spain.

Linda Monaci (L)

Institute of Sciences of Food Production (ISPA), National Research Council (CNR), Bari, Italy.

Elena Molina (E)

Instituto de Investigación en Ciencias de La Alimentación (CIAL), CSIC-UAM, Madrid, Spain.

Gabriel Mazzucchelli (G)

Mass Spectrometry Laboratory, MolSys Research Unit, University of Liege, 4000, Liege, Belgium.

Isabel Mafra (I)

REQUIMTE-LAQV/Faculdade de Farmácia, Universidade Do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313, Porto, Portugal.

Roberta Lupi (R)

INRAE UR 1268, Biopolymers Interactions Assemblies, Nantes, France.

Daniel Lozano-Ojalvo (D)

Precision Immunology Institute. Jaffe Food Allergy Institute. Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Colette Larré (C)

INRAE UR 1268, Biopolymers Interactions Assemblies, Nantes, France.

Julia Klueber (J)

Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Department of Dermatology and Allergy Center, Odense Research Center for Anaphylaxis, University of Southern Denmark, Odense C, Denmark.

Eva Gelencser (E)

Department of Biology, Food Science Research Institute, National Agricultural Research and Innovation Centre, Budapest, Hungary.

Cristina Bueno-Diaz (C)

Departmento de Bioquímica Y Biología Molecular, Facultad de Ciencias Químicas de la Universidad Complutense de Madrid, Madrid, Spain.

Araceli Diaz-Perales (A)

Centro de Biotecnologia Y Genomica de Plantas (UPM-INIA), Universidad Politecnica de Madrid, Pozuelo de Alarcon, Spain.

Sara Benedé (S)

Instituto de Investigación en Ciencias de La Alimentación (CIAL), CSIC-UAM, Madrid, Spain.

Simona Lucia Bavaro (SL)

Institute of Sciences of Food Production (ISPA), National Research Council (CNR), Bari, Italy.
Moorepark Food Research Centre, Teagasc, Fermoy, Co. Cork, Ireland.

Annette Kuehn (A)

Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.

Karin Hoffmann-Sommergruber (K)

Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.

Thomas Holzhauser (T)

Division of Allergology, Paul-Ehrlich-Institut, Langen, Germany.

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