New insight in understanding the contribution of SGLT1 in cardiac glucose uptake: evidence for a truncated form in mice and humans.
Animals
Biological Transport
Cells, Cultured
Glucose
/ metabolism
Glucose Transporter Type 4
/ antagonists & inhibitors
Hypoglycemic Agents
/ pharmacology
Insulin
/ pharmacology
Male
Mice, Inbred C57BL
Mice, Knockout
Myocytes, Cardiac
/ metabolism
Phlorhizin
/ pharmacology
Protein Isoforms
Rats, Wistar
Sodium-Glucose Transporter 1
/ antagonists & inhibitors
SGLT1
glucose uptake
myocardium
phlorizin
slc5a1 variant
Journal
American journal of physiology. Heart and circulatory physiology
ISSN: 1522-1539
Titre abrégé: Am J Physiol Heart Circ Physiol
Pays: United States
ID NLM: 100901228
Informations de publication
Date de publication:
01 02 2021
01 02 2021
Historique:
pubmed:
9
1
2021
medline:
23
3
2021
entrez:
8
1
2021
Statut:
ppublish
Résumé
Although sodium glucose cotransporter 1 (SGLT1) has been identified as one of the major SGLT isoforms expressed in the heart, its exact role remains elusive. Evidence using phlorizin, the most common inhibitor of SGLTs, has suggested its role in glucose transport. However, phlorizin could also affect classical facilitated diffusion via glucose transporters (GLUTs), bringing into question the relevance of SGLT1 in overall cardiac glucose uptake. Accordingly, we assessed the contribution of SGLT1 in cardiac glucose uptake using the SGLT1 knockout mouse model, which lacks exon 1. Glucose uptake was similar in cardiomyocytes isolated from SGLT1-knockout (
Identifiants
pubmed: 33416451
doi: 10.1152/ajpheart.00736.2019
pmc: PMC8082801
doi:
Substances chimiques
Glucose Transporter Type 4
0
Hypoglycemic Agents
0
Insulin
0
Protein Isoforms
0
SLC5A1 protein, human
0
Slc2a4 protein, mouse
0
Slc5a1 protein, mouse
0
Slc5a1 protein, rat
0
Sodium-Glucose Transporter 1
0
Phlorhizin
CU9S17279X
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
H838-H853Références
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