Five-Year Lower Extremity Function is Associated with White Matter Abnormality in Older Adults.
Activities of Daily Living
Aged
Connectome
/ methods
Correlation of Data
Diffusion Tensor Imaging
/ methods
Disease Progression
Female
Humans
Lower Extremity
/ physiopathology
Male
Mobility Limitation
Nerve Net
/ diagnostic imaging
Physical Functional Performance
Walking Speed
White Matter
/ diagnostic imaging
diffusion tensor imaging
lower extremity function
older adults
white matter
Journal
Journal of the American Geriatrics Society
ISSN: 1532-5415
Titre abrégé: J Am Geriatr Soc
Pays: United States
ID NLM: 7503062
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
revised:
24
11
2020
received:
07
09
2020
accepted:
24
11
2020
pubmed:
9
1
2021
medline:
24
9
2021
entrez:
8
1
2021
Statut:
ppublish
Résumé
To explore associations between changes of lower extremity function (LEF) parameters over a 5-year period and diffusion tensor imaging (DTI) parameters of white matter tracts among community-dwelling older adults. A secondary analysis on image and physical function data collected from the Multidomain Alzheimer's Preventive Trial (MAPT). 208 older adults (aged 75 ± 4 years, with spontaneous memory complaint or limited instrumental daily living activity or slow gait speed, 60% female) of the MAPT-magnetic resonance imaging (MRI) ancillary study. The time interval between a participant's enrolment and MRI scan was on average 110 ± 97 days. Forty-eight white matter tracts (WMTs) were measured. LEF parameters (measured after the MRI scan) were assessed as the short physical performance battery (SPPB) score, gait speed, and chair stands time over a 5-year period. Mixed-effects models were performed to explore the associations between baseline DTI values and the progression of LEF parameters. Bonferroni correction was applied for multiple comparison correction. The progression of LEF was associated with 35 baseline DTI parameters from 24 WMTs. Higher baseline DTI parameter values were related to more decreases in SPPB score and gait speed, and greater increases in chair stands time. Bilateral uncinate fasciculus was associated with all LEF parameters. Other WMTs in cingulum, cerebral and cerebellar peduncle, internal capsule, and corpus callosum also showed close connections with LEF changes. Our findings show that DTI parameters of some WMTs are associated with the 5-year decline in LEF, suggesting that alterations in WMT integrity (evaluated by DTI parameters) might be used to explore potential causes of impaired mobility in older adults when no clear explanations can be found.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
995-1002Informations de copyright
© 2021 The American Geriatrics Society.
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