Harnessing the Membrane Translocation Properties of AB Toxins for Therapeutic Applications.
anthrax toxin
botulinum toxin
cholera toxin
drug delivery
endocytosis
membrane translocation
therapeutic applications
Journal
Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765
Informations de publication
Date de publication:
06 Jan 2021
06 Jan 2021
Historique:
received:
04
11
2020
revised:
28
12
2020
accepted:
01
01
2021
entrez:
9
1
2021
pubmed:
10
1
2021
medline:
8
7
2021
Statut:
epublish
Résumé
Over the last few decades, proteins and peptides have become increasingly more common as FDA-approved drugs, despite their inefficient delivery due to their inability to cross the plasma membrane. In this context, bacterial two-component systems, termed AB toxins, use various protein-based membrane translocation mechanisms to deliver toxins into cells, and these mechanisms could provide new insights into the development of bio-based drug delivery systems. These toxins have great potential as therapies both because of their intrinsic properties as well as the modular characteristics of both subunits, which make them highly amenable to conjugation with various drug classes. This review focuses on the therapeutical approaches involving the internalization mechanisms of three representative AB toxins: botulinum toxin type A, anthrax toxin, and cholera toxin. We showcase several specific examples of the use of these toxins to develop new therapeutic strategies for numerous diseases and explain what makes these toxins promising tools in the development of drugs and drug delivery systems.
Identifiants
pubmed: 33418946
pii: toxins13010036
doi: 10.3390/toxins13010036
pmc: PMC7825107
pii:
doi:
Substances chimiques
Bacterial Toxins
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : 310030B_176393
Pays : International
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