Discovery of an endometrioid cancer lymph node metastasis without primary tumor in a context of Lynch syndrome.
Carcinoma, Endometrioid
/ pathology
Colorectal Neoplasms, Hereditary Nonpolyposis
/ genetics
DNA-Binding Proteins
/ genetics
Female
Genetic Predisposition to Disease
Humans
Hysterectomy
Lymphatic Metastasis
/ pathology
Middle Aged
Mutation
Neoplasms, Unknown Primary
Prophylactic Surgical Procedures
Salpingo-oophorectomy
Hysterectomy
Lynch syndrome
Pelvic nodes
Prophylactic surgery
Journal
Journal of gynecology obstetrics and human reproduction
ISSN: 2468-7847
Titre abrégé: J Gynecol Obstet Hum Reprod
Pays: France
ID NLM: 101701588
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
29
11
2020
revised:
28
12
2020
accepted:
31
12
2020
pubmed:
10
1
2021
medline:
25
2
2023
entrez:
9
1
2021
Statut:
ppublish
Résumé
Lynch syndrome is a hereditary predisposition to cancers, including colo-rectal and endometrial cancers in women. Prophylactic surgery including hysterectomy and bilateral salpingo-oophorectomy is recommended once the parental project is completed in case of identified mutation. We describe the case of a 50-year-old patient with Lynch syndrome and identified MSH6 mutation who underwent a prophylactic hysterectomy with bilateral salpingo-oophorectomy. A left large broad ligament lesion suggestive of a fibroma was intraoperatively discovered and removed. Pathological examination and immunohistochemical study showed a lymph node macro-metastasis of an endometrioid adenocarcinoma, without primary tumor. Lymph node metastasis can occur before endometrial cancer but the link with Lynch syndrome remains to be proved. Lymph node assessment by imaging before prophylactic surgery in Lynch syndrome could be considered.
Identifiants
pubmed: 33421625
pii: S2468-7847(21)00002-7
doi: 10.1016/j.jogoh.2021.102060
pii:
doi:
Substances chimiques
DNA-Binding Proteins
0
G-T mismatch-binding protein
0
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
102060Informations de copyright
Copyright © 2021 Elsevier Masson SAS. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors report no declarations of interest.