Common variants in MAEA gene contributed the susceptibility to osteoporosis in Han Chinese postmenopausal women.
Asian People
Bone Density
/ genetics
Case-Control Studies
Cell Adhesion Molecules
/ genetics
Cytoskeletal Proteins
/ genetics
Female
Genetic Association Studies
/ methods
Genetic Predisposition to Disease
/ genetics
Genetic Variation
/ genetics
Genotype
Haplotypes
Humans
Osteoporosis, Postmenopausal
/ genetics
Polymorphism, Single Nucleotide
Case-control study
Genetic association
Postmenopausal osteoporosis
Single nucleotide polymorphisms
Journal
Journal of orthopaedic surgery and research
ISSN: 1749-799X
Titre abrégé: J Orthop Surg Res
Pays: England
ID NLM: 101265112
Informations de publication
Date de publication:
10 Jan 2021
10 Jan 2021
Historique:
received:
18
06
2020
accepted:
30
11
2020
entrez:
11
1
2021
pubmed:
12
1
2021
medline:
13
7
2021
Statut:
epublish
Résumé
Osteoporosis (OP) is a complex bone metabolism disorder characterized by the loss of bone minerals and an increased risk of bone fracture. A recent study reported the relationship of the macrophage erythroblast attacher gene (MAEA) with low bone mineral density in postmenopausal Japanese women. Our study aimed to investigate the association of MAEA with postmenopausal osteoporosis (PMOP) in Han Chinese individuals. A total of 968 unrelated postmenopausal Chinese women comprising 484 patients with PMOP and 484 controls were recruited. Four tag single nucleotide polymorphisms (SNPs) that covered the gene region of MAEA were chosen for genotyping. Single SNP and haplotypic association analyses were performed, and analysis of variance was conducted to test the correlation between blood MAEA protein level and genotypes of associated SNPs. SNP rs6815464 was significantly associated with the risk of PMOP. The C allele of rs6815464 was strongly correlated with the decreased risk of PMOP in our study subjects (OR[95% CI]=0.75[0.63-0.89], P=0.0015). Significant differences in MAEA protein blood levels among genotypes of SNP rs6815464 were identified in both the PMOP (F=6.82, P=0.0012) and control groups (F=11.5, P=0.00001). The C allele was positively associated with decreased MAEA protein levels in blood. This case-control study on Chinese postmenopausal women suggested an association between SNP rs6815464 of MAEA and PMOP. Further analyses showed that genotypes of SNP rs6815464 were also associated with the blood level of MAEA protein.
Sections du résumé
BACKGROUND
BACKGROUND
Osteoporosis (OP) is a complex bone metabolism disorder characterized by the loss of bone minerals and an increased risk of bone fracture. A recent study reported the relationship of the macrophage erythroblast attacher gene (MAEA) with low bone mineral density in postmenopausal Japanese women. Our study aimed to investigate the association of MAEA with postmenopausal osteoporosis (PMOP) in Han Chinese individuals.
METHODS
METHODS
A total of 968 unrelated postmenopausal Chinese women comprising 484 patients with PMOP and 484 controls were recruited. Four tag single nucleotide polymorphisms (SNPs) that covered the gene region of MAEA were chosen for genotyping. Single SNP and haplotypic association analyses were performed, and analysis of variance was conducted to test the correlation between blood MAEA protein level and genotypes of associated SNPs.
RESULTS
RESULTS
SNP rs6815464 was significantly associated with the risk of PMOP. The C allele of rs6815464 was strongly correlated with the decreased risk of PMOP in our study subjects (OR[95% CI]=0.75[0.63-0.89], P=0.0015). Significant differences in MAEA protein blood levels among genotypes of SNP rs6815464 were identified in both the PMOP (F=6.82, P=0.0012) and control groups (F=11.5, P=0.00001). The C allele was positively associated with decreased MAEA protein levels in blood.
CONCLUSION
CONCLUSIONS
This case-control study on Chinese postmenopausal women suggested an association between SNP rs6815464 of MAEA and PMOP. Further analyses showed that genotypes of SNP rs6815464 were also associated with the blood level of MAEA protein.
Identifiants
pubmed: 33423677
doi: 10.1186/s13018-020-02140-4
pii: 10.1186/s13018-020-02140-4
pmc: PMC7798333
doi:
Substances chimiques
Cell Adhesion Molecules
0
Cytoskeletal Proteins
0
MAEA protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
38Subventions
Organisme : Fundamental Research Funds for Central Universities of the Central South University
ID : XJJ2018124
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