Pegylated arginine deiminase depletes plasma arginine but maintains tissue arginine availability in young pigs.
arginine
arginine deiminase
citrulline
swine
tracer kinetics
Journal
American journal of physiology. Endocrinology and metabolism
ISSN: 1522-1555
Titre abrégé: Am J Physiol Endocrinol Metab
Pays: United States
ID NLM: 100901226
Informations de publication
Date de publication:
01 03 2021
01 03 2021
Historique:
pubmed:
12
1
2021
medline:
27
3
2021
entrez:
11
1
2021
Statut:
ppublish
Résumé
Pegylated arginine deiminase (ADI-PEG20) results in the depletion of arginine with the production of isomolar amounts of citrulline. This citrulline has the potential to be utilized by the citrulline recycling pathway regenerating arginine and sustaining tissue arginine availability. The goal of this research was to test the hypothesis that ADI-PEG20 depletes circulating arginine in pigs but maintains tissue arginine concentration and function, and to characterize the kinetics of citrulline and arginine. Two multitracer approaches (bolus dose and primed-continuous infusion) were used to investigate the metabolism of arginine and citrulline in Control (
Identifiants
pubmed: 33427052
doi: 10.1152/ajpendo.00472.2020
pmc: PMC7988784
doi:
Substances chimiques
Citrulline
29VT07BGDA
Polyethylene Glycols
3WJQ0SDW1A
Arginine
94ZLA3W45F
Hydrolases
EC 3.-
ADI PEG20
EC 3.5.3.6
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
E641-E652Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM108940
Pays : United States
Organisme : U.S. Department of Agriculture (USDA)
ID : 58-6250-6-001
Organisme : HHS | NIH | National Institute of General Medical Sciences (NIGMS)
ID : GM108940
Références
BMC Neurosci. 2012 Apr 26;13:41
pubmed: 22536786
J Nutr. 2012 Mar;142(3):572-80
pubmed: 22323761
JPEN J Parenter Enteral Nutr. 2004 Nov-Dec;28(6):423-30
pubmed: 15568289
J Clin Hypertens (Greenwich). 2006 Dec;8(12 Suppl 4):17-29
pubmed: 17170603
PLoS One. 2015 Mar 16;10(3):e0119801
pubmed: 25775142
Curr Opin Mol Ther. 2006 Jun;8(3):240-8
pubmed: 16774044
J Nutr. 2020 Mar 1;150(3):423-424
pubmed: 31868220
J Nutr. 2018 Jun 1;148(6):844-850
pubmed: 29878271
Crit Care Med. 2011 Feb;39(2):380-5
pubmed: 21150584
Clin Sci (Lond). 2009 Jun 02;117(1):23-30
pubmed: 19105791
Am J Physiol Renal Physiol. 2020 Jan 1;318(1):F175-F182
pubmed: 31760772
Invest New Drugs. 2013 Apr;31(2):425-34
pubmed: 22864522
J Clin Oncol. 2004 May 15;22(10):1815-22
pubmed: 15143074
Ann Oncol. 2018 Jun 1;29(6):1402-1408
pubmed: 29659672
Genet Med. 2018 Jul;20(7):708-716
pubmed: 29693650
Cancer Res Treat. 2013 Dec;45(4):251-62
pubmed: 24453997
Curr Pharm Des. 2008;14(11):1049-57
pubmed: 18473854
J Nutr. 2017 Apr;147(4):596-602
pubmed: 28179487
Transl Oncol. 2012 Feb;5(1):26-31
pubmed: 22348173
Nutr Metab (Lond). 2016 Aug 31;13(1):60
pubmed: 27582779
Am J Physiol Endocrinol Metab. 2012 Nov 15;303(10):E1177-89
pubmed: 23011059
Am J Physiol Renal Physiol. 2014 Sep 15;307(6):F660-5
pubmed: 25056350
Crit Care Explor. 2020 Jul 16;2(7):e0150
pubmed: 32766551
Proc Natl Acad Sci U S A. 1993 Aug 15;90(16):7749-53
pubmed: 8356080
J Cancer Res Clin Oncol. 2015 Aug;141(8):1363-9
pubmed: 25548129
Am J Physiol Endocrinol Metab. 2007 Sep;293(3):E666-71
pubmed: 17535855
Adv Drug Deliv Rev. 2009 Nov 12;61(13):1177-88
pubmed: 19671438
Clin Cancer Res. 2015 Jun 1;21(11):2480-6
pubmed: 25739672
Am J Physiol Endocrinol Metab. 2001 Jun;280(6):E937-46
pubmed: 11350775
Nat Med. 2011 Nov 13;17(12):1619-26
pubmed: 22081021
JAMA. 2005 Jul 6;294(1):81-90
pubmed: 15998894
J Nutr. 2020 Mar 1;150(3):443-449
pubmed: 31687740
Am J Physiol Endocrinol Metab. 2017 Aug 1;313(2):E233-E242
pubmed: 28611027
J Nutr. 2015 Jun;145(6):1227-31
pubmed: 25855119
J Nutr. 2004 Oct;134(10 Suppl):2791S-2795S; discussion 2796S-2797S
pubmed: 15465786
J Nutr. 2016 Dec;146(12):2579S-2586S
pubmed: 27934648
Am J Physiol Endocrinol Metab. 2012 Dec 1;303(11):E1348-53
pubmed: 23074237