Chronic generalized pain disrupts whole brain functional connectivity in mice.
Biomarker
Fibromyalgia
Mice
Periaqueductal gray
Resting-state fMRI
Retrosplenial cortex
Sluka model
Journal
Brain imaging and behavior
ISSN: 1931-7565
Titre abrégé: Brain Imaging Behav
Pays: United States
ID NLM: 101300405
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
accepted:
20
12
2020
pubmed:
12
1
2021
medline:
13
10
2021
entrez:
11
1
2021
Statut:
ppublish
Résumé
Fibromyalgia (FM) is a generalized chronic pain condition whose pathophysiology is poorly understood, and both basic and translational research are needed to advance the field. Here we used the Sluka model to test whether FM-like pain in mice would produce detectable brain modifications using resting-state (rs) functional Magnetic Resonance Imaging (fMRI). Mice received intramuscular acid saline treatment, images were acquired at 7 T 5 days post-treatment, and pain thresholds tested 3 weeks post-scanning. Data-driven Independent Component Analysis revealed significant reduction of functional connectivity (FC) across several component pairs, with major changes for the Retrosplenial cortex (RSP) central to the default mode network, and to a lesser extent the Periaqueductal gray (PAG), a key pain processing area. Seed-to-seed analysis focused on 14 pain-related areas showed strongest FC reduction for RSP with several cortical areas (somatosensory, prefrontal and insular), and for PAG with both cortical (somatosensory) and subcortical (habenula, thalamus, parabrachial nucleus) areas. RSP-PAG FC was also reduced, and this decreased FC tended to be positively correlated with pain levels at individual subject level. Finally, seed-voxelwise analysis focused on PAG confirmed seed-to-seed findings and, also detected reduced PAG FC with the anterior cingulate cortex, increasingly studied in aversive pain effects. In conclusion, FM-like pain triggers FC alterations in the mouse, which are detected by rs-fMRI and are reminiscent of some human findings. The study reveals the causal fingerprint of FM-like pain in rodents, and indicates that both RSP and PAG connectional patterns could be suitable biomarkers, with mechanistic and translational value, for further investigations.
Identifiants
pubmed: 33428113
doi: 10.1007/s11682-020-00438-9
pii: 10.1007/s11682-020-00438-9
pmc: PMC8272737
mid: NIHMS1698729
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2406-2416Subventions
Organisme : NIDA NIH HHS
ID : P50 DA005010
Pays : United States
Organisme : NIAAA NIH HHS
ID : U01 AA016658
Pays : United States
Organisme : NIAAA NIH HHS
ID : 16658
Pays : United States
Organisme : NIDA NIH HHS
ID : 05010
Pays : United States
Organisme : NIDA NIH HHS
ID : 05010
Pays : United States
Organisme : NIAAA NIH HHS
ID : 16658
Pays : United States
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.
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