Ythdf is a N6-methyladenosine reader that modulates Fmr1 target mRNA selection and restricts axonal growth in Drosophila.

Adenosine / analogs & derivatives Animals Axons / physiology Drosophila Proteins / genetics Drosophila melanogaster Fragile X Mental Retardation Protein / genetics Neurons / cytology RNA, Messenger / genetics RNA-Binding Proteins / genetics
Fmr1 RNA modification Ythdf m6A nervous system

Journal

The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664

Informations de publication

Date de publication:
15 02 2021
Historique:
received: 12 03 2020
revised: 18 11 2020
accepted: 30 11 2020
pubmed: 12 1 2021
medline: 21 10 2021
entrez: 11 1 2021
Statut: ppublish

Résumé

N6-methyladenosine (m

Identifiants

DOI: 10.15252/embj.2020104975 PMID: 33428246 PMC: PMC7883056
pubmed: 33428246
doi: 10.15252/embj.2020104975
pmc: PMC7883056
doi:

Substances chimiques

Drosophila Proteins 0
FMR1 protein, Drosophila 0
RNA, Messenger 0
RNA-Binding Proteins 0
Fragile X Mental Retardation Protein 139135-51-6
N-methyladenosine CLE6G00625
Adenosine K72T3FS567

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e104975

Informations de copyright

© 2021 The Authors. Published under the terms of the CC BY NC ND 4.0 license.

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Auteurs

Lina Worpenberg (L)

Center for Integrative Genomics, Génopode Building, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.

Chiara Paolantoni (C)

Center for Integrative Genomics, Génopode Building, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.

Sara Longhi (S)

Laboratory of Translational Genomics, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Trento, Italy.

Miriam M Mulorz (MM)

Institute of Molecular Biology (IMB), Mainz, Germany.

Tina Lence (T)

Institute of Molecular Biology (IMB), Mainz, Germany.
ORCID: 0000-0001-9377-546X

Hans-Hermann Wessels (HH)

Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology (BIMSB), Berlin, Germany.
Department of Biology, Humboldt University Berlin, Berlin, Germany.
ORCID: 0000-0001-5551-404X

Erik Dassi (E)

Laboratory of RNA Regulatory Networks, Department CIBIO, University of Trento, Trento, Italy.

Giuseppe Aiello (G)

Armenise-Harvard Laboratory of Brain Disorders and Cancer, Department CIBIO, University of Trento, Trento, Italy.
ORCID: 0000-0001-8723-2127

F X Reymond Sutandy (FXR)

Institute of Molecular Biology (IMB), Mainz, Germany.

Marion Scheibe (M)

Institute of Molecular Biology (IMB), Mainz, Germany.

Raghu R Edupuganti (RR)

Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Oncode Institute, Radboud University Nijmegen, Nijmegen, The Netherlands.

Anke Busch (A)

Bioinformatics Core Facility, IMB, Mainz, Germany.

Martin M Möckel (MM)

Protein Production Core Facility, IMB, Mainz, Germany.

Michiel Vermeulen (M)

Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Oncode Institute, Radboud University Nijmegen, Nijmegen, The Netherlands.
ORCID: 0000-0003-0836-6894

Falk Butter (F)

Institute of Molecular Biology (IMB), Mainz, Germany.
ORCID: 0000-0002-7197-7279

Julian König (J)

Institute of Molecular Biology (IMB), Mainz, Germany.

Michela Notarangelo (M)

Laboratory of Translational Genomics, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Trento, Italy.

Uwe Ohler (U)

Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology (BIMSB), Berlin, Germany.
Department of Biology, Humboldt University Berlin, Berlin, Germany.
ORCID: 0000-0002-0881-3116

Christoph Dieterich (C)

Klaus Tschira Institute for Integrative Computational Cardiology and Department of Internal Medicine III, University Hospital Heidelberg, Heidelberg, Germany.
German Center for Cardiovascular Research (DZHK), Partner site Heidelberg-Mannheim, Heidelberg, Germany.
ORCID: 0000-0001-9468-6311

Alessandro Quattrone (A)

Center for Integrative Genomics, Génopode Building, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
Laboratory of Translational Genomics, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Trento, Italy.
ORCID: 0000-0003-3333-7630

Alessia Soldano (A)

Laboratory of Translational Genomics, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Trento, Italy.
ORCID: 0000-0002-3120-9929

Jean-Yves Roignant (JY)

Center for Integrative Genomics, Génopode Building, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg-University Mainz, Mainz, Germany.
ORCID: 0000-0003-1395-2150

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Ribonucléosides › Adénosine › Ythdf is a N6-methyladenosine reader that...
questionsmedicales.fr › Eucaryotes › Animaux › Ythdf is a N6-methyladenosine reader that...
questionsmedicales.fr › Cellules › Neurones › Neurofibres › Axones › Ythdf is a N6-methyladenosine reader that...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines d'arthropode › Protéines d'insecte › Protéines de Drosophila › Ythdf is a N6-methyladenosine reader that...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Drosophilidae › Drosophila › Drosophila melanogaster › Ythdf is a N6-methyladenosine reader that...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Protéine du syndrome X fragile › Ythdf is a N6-methyladenosine reader that...
questionsmedicales.fr › Cellules › Neurones › Ythdf is a N6-methyladenosine reader that...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Ythdf is a N6-methyladenosine reader that...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Ythdf is a N6-methyladenosine reader that...