Multitarget Biological Profiling of New Naphthoquinone and Anthraquinone-Based Derivatives for the Treatment of Alzheimer's Disease.

Acetylcholinesterase / metabolism Alzheimer Disease / drug therapy Amyloid beta-Peptides Anthraquinones / pharmacology Cholinesterase Inhibitors / pharmacology Drug Design Humans Monoamine Oxidase / metabolism Monoamine Oxidase Inhibitors / pharmacology Naphthoquinones / pharmacology Structure-Activity Relationship
AChE and BChE inhibition Aβ and Tau aggregation inhibition MAO inhibition Naphthoquinone and anthraquinone derivatives multitarget-directed ligands (MTDLs)

Journal

ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337

Informations de publication

Date de publication:
03 02 2021
Historique:
pubmed: 12 1 2021
medline: 22 6 2021
entrez: 11 1 2021
Statut: ppublish

Résumé

Two series of naphthoquinone and anthraquinone derivatives decorated with an aromatic/heteroaromatic chain have been synthesized and evaluated as potential promiscuous agents capable of targeting different factors playing a key role in Alzheimer's disease (AD) pathogenesis. On the basis of the

Identifiants

DOI: 10.1021/acschemneuro.0c00624 PMID: 33428389 PMC: PMC7880572
pubmed: 33428389
doi: 10.1021/acschemneuro.0c00624
pmc: PMC7880572
doi:

Substances chimiques

Amyloid beta-Peptides 0
Anthraquinones 0
Cholinesterase Inhibitors 0
Monoamine Oxidase Inhibitors 0
Naphthoquinones 0
Monoamine Oxidase EC 1.4.3.4
Acetylcholinesterase EC 3.1.1.7

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

447-461

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Auteurs

Marta Campora (M)

Department of Pharmacy, University of Genoa, Viale Benedetto XV 3, 16132 Genoa, Italy.

Claudio Canale (C)

Department of Physics, University of Genoa, Via Dodecaneso 33, 16146 Genoa, Italy.

Elena Gatta (E)

Department of Physics, University of Genoa, Via Dodecaneso 33, 16146 Genoa, Italy.

Bruno Tasso (B)

Department of Pharmacy, University of Genoa, Viale Benedetto XV 3, 16132 Genoa, Italy.

Erik Laurini (E)

Molecular Biology and Nanotechnology Laboratory (MolBNL@UniTS), Department of Engineering and Architecture, University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy.
ORCID: 0000-0001-6092-6532

Annalisa Relini (A)

Department of Physics, University of Genoa, Via Dodecaneso 33, 16146 Genoa, Italy.
ORCID: 0000-0002-4040-9279

Sabrina Pricl (S)

Molecular Biology and Nanotechnology Laboratory (MolBNL@UniTS), Department of Engineering and Architecture, University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy.
Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Poland.

Marco Catto (M)

Department of Pharmacy-Drug Sciences, University of Bari Aldo Moro, Via E. Orabona 4, 70125 Bari, Italy.
ORCID: 0000-0002-8411-304X

Michele Tonelli (M)

Department of Pharmacy, University of Genoa, Viale Benedetto XV 3, 16132 Genoa, Italy.
ORCID: 0000-0003-1518-2890

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Cholinesterases › Acetylcholinesterase › Multitarget Biological Profiling of New...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Multitarget Biological Profiling of New...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › Multitarget Biological Profiling of New...
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Anthracènes › Anthraquinones › Multitarget Biological Profiling of New...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents cholinergiques › Anticholinestérasiques › Multitarget Biological Profiling of New...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Conception de médicament › Multitarget Biological Profiling of New...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Multitarget Biological Profiling of New...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-NH2 group donors › Monoamine oxidase › Multitarget Biological Profiling of New...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de la monoamine oxydase › Multitarget Biological Profiling of New...
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Naphtalènes › Naphtoquinones › Multitarget Biological Profiling of New...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Multitarget Biological Profiling of New...