The neuroprotective effect of oxytocin on vincristine-induced neurotoxicity in mice.
Animals
Antineoplastic Agents, Phytogenic
/ toxicity
Hyperalgesia
/ chemically induced
Mice
Mice, Knockout
Neurotoxicity Syndromes
/ drug therapy
Oxytocics
/ toxicity
Oxytocin
/ therapeutic use
Peripheral Nervous System Diseases
/ chemically induced
Receptors, Oxytocin
/ antagonists & inhibitors
Sciatic Nerve
/ drug effects
Vasotocin
/ analogs & derivatives
Vincristine
/ toxicity
DRG
Hyperalgesia
Neurite
Neuropathy
Neurotrophic
Journal
Toxicology letters
ISSN: 1879-3169
Titre abrégé: Toxicol Lett
Pays: Netherlands
ID NLM: 7709027
Informations de publication
Date de publication:
01 Apr 2021
01 Apr 2021
Historique:
received:
21
07
2020
revised:
01
12
2020
accepted:
04
01
2021
pubmed:
12
1
2021
medline:
23
2
2021
entrez:
11
1
2021
Statut:
ppublish
Résumé
Vincristine (VCR) is commonly used to treat a variety of hematological malignancies and solid tumors in pediatric and adult patients. However, peripheral neuropathy is a dose-limiting side effect that leaves some patients with functional disability and long-term pain. Oxytocin (OT) has demonstrated analgesic and anti-inflammatory properties, but there is no evidence regarding its effects on VCR-induced neurotoxicity. Therefore, we evaluated the potential protective effects of OT on VCR-induced neurotoxicity. In vitro, VCR (0.005 ∼ 0.1 μmol/l) and OT (10
Identifiants
pubmed: 33429010
pii: S0378-4274(21)00009-6
doi: 10.1016/j.toxlet.2021.01.008
pii:
doi:
Substances chimiques
Antineoplastic Agents, Phytogenic
0
Oxytocics
0
Receptors, Oxytocin
0
atosiban
081D12SI0Z
Oxytocin
50-56-6
Vincristine
5J49Q6B70F
Vasotocin
W6S6URY8OF
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
67-76Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.