Long-term outcomes of autologous skeletal myoblast cell-sheet transplantation for end-stage ischemic cardiomyopathy.
Cardiomyopathies
/ genetics
Female
Heart
/ growth & development
Heart Failure
/ genetics
Heart Ventricles
/ pathology
Humans
Male
Middle Aged
Myoblasts
/ transplantation
Myocardial Ischemia
/ genetics
Stroke Volume
/ genetics
Transplantation, Autologous
/ adverse effects
Ventricular Function, Left
/ genetics
heart failure
ischemic cardiomyopathy
regenerative therapy
responder
sheet transplantation
stem cell
Journal
Molecular therapy : the journal of the American Society of Gene Therapy
ISSN: 1525-0024
Titre abrégé: Mol Ther
Pays: United States
ID NLM: 100890581
Informations de publication
Date de publication:
07 04 2021
07 04 2021
Historique:
received:
25
08
2020
revised:
30
11
2020
accepted:
02
01
2021
pubmed:
12
1
2021
medline:
20
11
2021
entrez:
11
1
2021
Statut:
ppublish
Résumé
We evaluated the cardiac function recovery following skeletal myoblast cell-sheet transplantation and the long-term outcomes after applying this treatment in 23 patients with ischemic cardiomyopathy. We defined patients as "responders" when their left ventricular ejection fraction remained unchanged or improved at 6 months after treatment. At 6 months, 16 (69.6%) patients were defined as responders, and the average increase in left ventricular ejection fraction was 4.9%. The responders achieved greater improvement degrees in left ventricular and hemodynamic function parameters, and they presented improved exercise capacity. During the follow-up period (56 ± 28 months), there were four deaths and the overall 5-year survival rate was 95%. Although the responders showed higher freedom from mortality and/or heart failure admission (5-year, 81% versus 0%; p = 0.0002), both groups presented an excellent 5-year survival rate (5-year, 93% versus 100%; p = 0.297) that was higher than that predicted using the Seattle Heart Failure Model. The stepwise logistic regression analysis showed that the preoperative estimated glomerular filtration rate and the left ventricular end-systolic volume index were independently associated with the recovery progress. Approximately 70% of patients with "no-option" ischemic cardiomyopathy responded well to the cell-sheet transplantation. Preoperative renal and left ventricular function might predict the patients' response to this treatment.
Identifiants
pubmed: 33429079
pii: S1525-0016(21)00004-6
doi: 10.1016/j.ymthe.2021.01.004
pmc: PMC8058489
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1425-1438Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
Références
Circ J. 2015;79(5):991-9
pubmed: 25912561
Circ J. 2017 Feb 24;81(3):298-303
pubmed: 28070058
Int J Cardiol. 2013 Sep 20;168(1):261-9
pubmed: 23046598
JACC Cardiovasc Imaging. 2015 Oct;8(10):1121-1129
pubmed: 26363840
Circulation. 2001 Sep 18;104(12 Suppl 1):I314-8
pubmed: 11568075
Lancet. 2011 Aug 20;378(9792):704-12
pubmed: 21856484
Circ Res. 2002 Feb 22;90(3):e40
pubmed: 11861428
Circulation. 2013 Sep 10;128(11 Suppl 1):S87-94
pubmed: 24030425
Circulation. 2011 Sep 13;124(11 Suppl):S97-106
pubmed: 21911824
J Thorac Cardiovasc Surg. 2009 Oct;138(4):985-93
pubmed: 19769884
Circulation. 2012 Sep 11;126(11 Suppl 1):S29-37
pubmed: 22965990
Circulation. 1990 Sep;82(3):798-807
pubmed: 2144218
Transplantation. 2010 Aug 27;90(4):364-72
pubmed: 20555308
Circulation. 1987 Jul;76(1):44-51
pubmed: 3594774
Eur Heart J. 2010 Mar;31(6):703-11
pubmed: 20037146
Am J Kidney Dis. 2004 Sep;44(3):420-8
pubmed: 15332214
J Thorac Dis. 2015 Dec;7(12):2158-64
pubmed: 26793336
Lancet. 2014 May 31;383(9932):1933-43
pubmed: 24831770
Mol Ther. 2015 Feb;23(2):374-86
pubmed: 25421595
ESC Heart Fail. 2017 Nov;4(4):576-584
pubmed: 28872780
Circulation. 1997 Nov 4;96(9):2920-31
pubmed: 9386158
J Am Coll Cardiol. 2002 Jan 2;39(1):30-6
pubmed: 11755283
Circulation. 2012 Sep 11;126(11 Suppl 1):S205-13
pubmed: 22965985
Transplantation. 2012 Jun 15;93(11):1108-15
pubmed: 22499149
J Am Heart Assoc. 2017 Apr 5;6(4):
pubmed: 28381469
Circ J. 2016;80(1):44-50
pubmed: 26638870
N Engl J Med. 2011 Apr 28;364(17):1617-25
pubmed: 21463153
Eur Heart J. 2008 Aug;29(16):2000-5
pubmed: 18556713
ESC Heart Fail. 2020 Aug;7(4):1560-1570
pubmed: 32400096
Heart. 2009 Aug;95(15):1273-7
pubmed: 19443475
Tissue Eng Part A. 2014 Feb;20(3-4):728-39
pubmed: 24164292
Circulation. 2008 Mar 4;117(9):1189-200
pubmed: 18285565
Circulation. 1994 Dec;90(6):2899-904
pubmed: 7994836
J Am Coll Cardiol. 2004 Oct 6;44(7):1439-45
pubmed: 15464325
J Am Coll Cardiol. 2010 Jun 1;55(22):2459-69
pubmed: 20510213
EBioMedicine. 2019 Oct;48:377-385
pubmed: 31648988
J Am Coll Cardiol. 1997 Nov 15;30(6):1451-60
pubmed: 9362401
Circulation. 2006 Mar 21;113(11):1424-33
pubmed: 16534009
Eur J Heart Fail. 2014 Feb;16(2):189-200
pubmed: 24464828