How stem cells remember their past.

Cell Division Homeostasis Stem Cells
Asymmetric cell division Epigenetic Memory Stem cell

Journal

Current opinion in cell biology
ISSN: 1879-0410
Titre abrégé: Curr Opin Cell Biol
Pays: England
ID NLM: 8913428

Informations de publication

Date de publication:
04 2021
Historique:
received: 03 10 2020
revised: 26 11 2020
accepted: 12 12 2020
pubmed: 12 1 2021
medline: 5 10 2021
entrez: 11 1 2021
Statut: ppublish

Résumé

Somatic stem cells are required for tissue development, homeostasis, and repair. Recent data suggested that previous biographical experiences of individual stem cells influence their behavior in the context of tissue formation and govern stem cell responses to external stimuli. Here we provide a concise review how a cell's biography, for example, previous rounds of cell divisions or the age-dependent accumulation of cellular damage, is remembered in stem cells and how previous experiences affect the segregation of cellular components, thus guiding cellular behavior in vertebrate stem cells. Further, we suggest future directions of research that may help to unravel the molecular underpinnings of how past experiences guide future cellular behavior.

Identifiants

DOI: 10.1016/j.ceb.2020.12.008 PMID: 33429112
pubmed: 33429112
pii: S0955-0674(20)30173-3
doi: 10.1016/j.ceb.2020.12.008
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

17-22

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest statement Nothing declared.

Auteurs

Lars N Royall (LN)

Laboratory of Neural Plasticity, Faculties of Medicine and Science, Brain Research Institute, University of Zurich, 8057, Zurich, Switzerland.

Sebastian Jessberger (S)

Laboratory of Neural Plasticity, Faculties of Medicine and Science, Brain Research Institute, University of Zurich, 8057, Zurich, Switzerland. Electronic address: jessberger@hifo.uzh.ch.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Division cellulaire › How stem cells remember their past.
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › How stem cells remember their past.
questionsmedicales.fr › Cellules › Cellules souches › How stem cells remember their past.