Relationship between podoplanin-expressing cancer-associated fibroblasts and the immune microenvironment of early lung squamous cell carcinoma.

Cancer-Associated Fibroblasts Carcinoma, Squamous Cell Fibroblasts Humans Lung Lung Neoplasms / genetics Membrane Glycoproteins / genetics Tumor Microenvironment
cancer associated fibroblasts immune microenvironment lung squamous cell carcinoma podoplanin tumor-associated macrophage

Journal

Lung cancer (Amsterdam, Netherlands)
ISSN: 1872-8332
Titre abrégé: Lung Cancer
Pays: Ireland
ID NLM: 8800805

Informations de publication

Date de publication:
03 2021
Historique:
received: 03 10 2020
revised: 10 12 2020
accepted: 16 12 2020
pubmed: 12 1 2021
medline: 22 6 2021
entrez: 11 1 2021
Statut: ppublish

Résumé

Cancer-associated fibroblasts (CAFs) expressing podoplanin (PDPN) harbor a fibrous tumor microenvironment that promotes cancer progression in lung adenocarcinoma. In this study, we investigated whether tumor-promoting PDPN Analysis of TCGA database revealed that the PDPN-high group exhibited significantly higher expression of interleukin (IL)-1A, IL-1B, IL-6, IL-10, monocyte chemoattractant protein-1 (CCL2), colony stimulating factor 1 (CSF1), fibroblast growth factor 2 (FGF2), galectin 1 (LGALS1), platelet derived growth factor subunit A (PDGFA), PDGFB, and transforming growth factor-β1 (TGFB1) than those in the PDPN-low group. Among them, it was found that TGFB1 expression was higher in patient-derived PDPN PDPN

Identifiants

DOI: 10.1016/j.lungcan.2020.12.020 PMID: 33429158
pubmed: 33429158
pii: S0169-5002(20)30748-0
doi: 10.1016/j.lungcan.2020.12.020
pii:
doi:

Substances chimiques

Membrane Glycoproteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1-10

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Auteurs

Jun Suzuki (J)

Division of Pathology, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan; Department of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

Keiju Aokage (K)

Department of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

Shinya Neri (S)

Department of Thoracic Surgery, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, Japan.

Takashi Sakai (T)

Division of Pathology, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan; Department of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

Hiroko Hashimoto (H)

Division of Pathology, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

Yinghan Su (Y)

Division of Pathology, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

Shota Yamazaki (S)

Division of Pathology, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

Hiroshi Nakamura (H)

Division of Pathology, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

Kenta Tane (K)

Department of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

Tomohiro Miyoshi (T)

Department of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

Masato Sugano (M)

Department of Pathology and Clinical Laboratories, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

Motohiro Kojima (M)

Division of Pathology, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

Satoshi Fujii (S)

Division of Pathology, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan; Department of Molecular Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan.

Takeshi Kuwata (T)

Department of Pathology and Clinical Laboratories, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

Atsushi Ochiai (A)

Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, Japan.

Masahiro Tsuboi (M)

Department of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

Genichiro Ishii (G)

Division of Pathology, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan; Department of Pathology and Clinical Laboratories, National Cancer Center Hospital East, Kashiwa, Chiba, Japan. Electronic address: gishii@east.ncc.go.jp.

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Fibroblastes › Fibroblastes associés au cancer › Relationship between podoplanin-expressing...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Tumeurs épidermoïdes › Carcinome épidermoïde › Relationship between podoplanin-expressing...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Fibroblastes › Relationship between podoplanin-expressing...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Relationship between podoplanin-expressing...
questionsmedicales.fr › Appareil respiratoire › Poumon › Relationship between podoplanin-expressing...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Relationship between podoplanin-expressing...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Glycoprotéines membranaires › Relationship between podoplanin-expressing...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Relationship between podoplanin-expressing...