Bivalent Genes Targeting of Glioma Heterogeneity and Plasticity.
HOX genes
bivalency
bivalent genes
cancer
epigenetics
glioblastoma
glioma
glioma therapy
histones
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
07 Jan 2021
07 Jan 2021
Historique:
received:
02
12
2020
revised:
27
12
2020
accepted:
05
01
2021
entrez:
12
1
2021
pubmed:
13
1
2021
medline:
31
3
2021
Statut:
epublish
Résumé
Gliomas account for most primary Central Nervous System (CNS) neoplasms, characterized by high aggressiveness and low survival rates. Despite the immense research efforts, there is a small improvement in glioma survival rates, mostly attributed to their heterogeneity and complex pathophysiology. Recent data indicate the delicate interplay of genetic and epigenetic mechanisms in regulating gene expression and cell differentiation, pointing towards the pivotal role of bivalent genes. Bivalency refers to a property of chromatin to acquire more than one histone marks during the cell cycle and rapidly transition gene expression from an active to a suppressed transcriptional state. Although first identified in embryonal stem cells, bivalent genes have now been associated with tumorigenesis and cancer progression. Emerging evidence indicates the implication of bivalent gene regulation in glioma heterogeneity and plasticity, mainly involving Homeobox genes, Wingless-Type MMTV Integration Site Family Members, Hedgehog protein, and Solute Carrier Family members. These genes control a wide variety of cellular functions, including cellular differentiation during early organism development, regulation of cell growth, invasion, migration, angiogenesis, therapy resistance, and apoptosis. In this review, we discuss the implication of bivalent genes in glioma pathogenesis and their potential therapeutic targeting options.
Identifiants
pubmed: 33430434
pii: ijms22020540
doi: 10.3390/ijms22020540
pmc: PMC7826605
pii:
doi:
Substances chimiques
Chromatin
0
Hedgehog Proteins
0
Histones
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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