Lifestyle Intervention in Pregnant Women With Obesity Impacts Cord Blood DNA Methylation, Which Associates With Body Composition in the Offspring.
Journal
Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
11
05
2020
accepted:
01
01
2021
pubmed:
13
1
2021
medline:
24
8
2021
entrez:
12
1
2021
Statut:
ppublish
Résumé
Maternal obesity may lead to epigenetic alterations in the offspring and might thereby contribute to disease later in life. We investigated whether a lifestyle intervention in pregnant women with obesity is associated with epigenetic variation in cord blood and body composition in the offspring. Genome-wide DNA methylation was analyzed in cord blood from 208 offspring from the Treatment of Obese Pregnant women (TOP)-study, which includes pregnant women with obesity randomized to lifestyle interventions comprised of physical activity with or without dietary advice versus control subjects (standard of care). DNA methylation was altered at 379 sites, annotated to 370 genes, in cord blood from offspring of mothers following a lifestyle intervention versus control subjects (false discovery rate [FDR] <5%) when using the Houseman reference-free method to correct for cell composition, and three of these sites were significant based on Bonferroni correction. These 370 genes are overrepresented in gene ontology terms, including response to fatty acids and adipose tissue development. Offspring of mothers included in a lifestyle intervention were born with more lean mass compared with control subjects. Methylation at 17 sites, annotated to, for example,
Identifiants
pubmed: 33431374
pii: db20-0487
doi: 10.2337/db20-0487
pmc: PMC7980200
doi:
Banques de données
figshare
['10.2337/figshare.13501587']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
854-866Informations de copyright
© 2021 by the American Diabetes Association.
Références
Biostatistics. 2007 Jan;8(1):118-27
pubmed: 16632515
BMC Res Notes. 2014 May 02;7:278
pubmed: 24886386
Clin Epigenetics. 2019 Aug 27;11(1):125
pubmed: 31455416
PLoS One. 2015 Jul 20;10(7):e0133041
pubmed: 26192183
Natl Health Stat Report. 2009 May 5;(13):1-7
pubmed: 19634296
Nature. 2015 Feb 19;518(7539):317-30
pubmed: 25693563
PLoS One. 2011;6(7):e21800
pubmed: 21789182
Bioinformatics. 2016 Jan 15;32(2):286-8
pubmed: 26424855
Pediatrics. 1998 Nov;102(5):E60
pubmed: 9794990
Genom Data. 2016 May 26;9:22-4
pubmed: 27330998
N Engl J Med. 2010 Feb 11;362(6):485-93
pubmed: 20147714
Sci Rep. 2018 Jan 30;8(1):1898
pubmed: 29382913
Hum Mol Genet. 2017 Oct 15;26(20):4067-4085
pubmed: 29016858
PLoS Genet. 2017 Apr 27;13(4):e1006528
pubmed: 28448500
Bioinformatics. 2013 Jan 15;29(2):189-96
pubmed: 23175756
Bioinformatics. 2012 Mar 15;28(6):882-3
pubmed: 22257669
JCI Insight. 2018 Sep 6;3(17):
pubmed: 30185669
Horm Res Paediatr. 2015;83(4):242-51
pubmed: 25765181
Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17046-9
pubmed: 18955703
Am J Clin Nutr. 2017 Apr;105(4):991-1000
pubmed: 28275132
Nat Med. 2019 Sep;25(9):1390-1395
pubmed: 31501611
BMC Genomics. 2019 May 14;20(1):366
pubmed: 31088362
Diabetes. 2012 Dec;61(12):3322-32
pubmed: 23028138
Acta Paediatr. 2014 Sep;103(9):939-45
pubmed: 24942370
Cell Mol Life Sci. 2019 Mar;76(5):921-940
pubmed: 30470852
Obes Rev. 2016 Feb;17(2):95-107
pubmed: 26696565
Bioinformatics. 2004 Dec 12;20(18):3710-5
pubmed: 15297299
Hum Mol Genet. 2019 Oct 1;28(19):3327-3338
pubmed: 31504550
Diabetes. 2014 Sep;63(9):2962-76
pubmed: 24812430
Int J Obes (Lond). 2017 Apr;41(4):598-605
pubmed: 28093573
Lancet. 1999 May 22;353(9166):1789-92
pubmed: 10348008
Diabetes Care. 2020 Jan;43(1):98-105
pubmed: 31601636
Cell Metab. 2019 May 7;29(5):1028-1044
pubmed: 30982733
Genomics. 2011 Oct;98(4):288-95
pubmed: 21839163
Acta Obstet Gynecol Scand. 2010 Jul;89(7):956-61
pubmed: 20583938
Nucleic Acids Res. 2019 Jan 8;47(D1):D1005-D1012
pubmed: 30445434
Int J Obes (Lond). 2014 Jan;38(1):69-75
pubmed: 23779050
BMC Bioinformatics. 2010 Nov 30;11:587
pubmed: 21118553
Bioinformatics. 2014 May 15;30(10):1431-9
pubmed: 24451622
Source Code Biol Med. 2008 Dec 16;3:17
pubmed: 19087314
Cardiovasc Diabetol. 2018 Feb 5;17(1):23
pubmed: 29402279
Am J Obstet Gynecol. 2014 Feb;210(2):134.e1-9
pubmed: 24060449
Am J Clin Nutr. 2015 Dec;102(6):1475-81
pubmed: 26561621
J Steroid Biochem Mol Biol. 2017 Apr;168:71-90
pubmed: 28216152
BMC Med. 2017 Feb 22;15(1):39
pubmed: 28222718
Br J Nutr. 2015 Jul;114(2):316-27
pubmed: 26131962
Diabetologia. 2015 Jan;58(1):178-87
pubmed: 25287712
Bioinformatics. 2008 Jul 1;24(13):1547-8
pubmed: 18467348
J Biomed Res. 2012 Jul;26(4):235-40
pubmed: 23554754
Nutrients. 2018 Apr 06;10(4):
pubmed: 29642382
Genet Epidemiol. 2018 Feb;42(1):20-33
pubmed: 29034560