Primary Sjögren's syndrome manifesting as sclerotic metabolic bone disease.
Absorptiometry, Photon
Acidosis, Renal Tubular
/ blood
Adult
Alkaline Phosphatase
/ blood
Back Pain
/ blood
Bone Density
/ immunology
Bone Diseases, Metabolic
/ blood
Female
Humans
Potassium Citrate
/ therapeutic use
Radionuclide Imaging
Sjogren's Syndrome
/ blood
Skeleton
/ diagnostic imaging
Sodium Bicarbonate
/ therapeutic use
calcium and bone
sjogren's syndrome
Journal
BMJ case reports
ISSN: 1757-790X
Titre abrégé: BMJ Case Rep
Pays: England
ID NLM: 101526291
Informations de publication
Date de publication:
11 Jan 2021
11 Jan 2021
Historique:
entrez:
12
1
2021
pubmed:
13
1
2021
medline:
23
2
2021
Statut:
epublish
Résumé
Primary Sjögren's syndrome (pSS) is a chronic slowly progressive autoimmune disease characterised by lymphocytic infiltration of salivary and lacrimal glands with varying degree of systemic involvement. Renal involvement, a recognised extraglandular manifestation of pSS, is commonly related to tubular dysfunction and generally manifests as distal renal tubular acidosis (RTA), proximal RTA, tubular proteinuria and nephrogenic diabetes insipidus. Untreated long-standing RTA is known to cause metabolic bone disease. Here, we present the report of a patient with sclerotic metabolic bone disease related to pSS with combined distal and proximal RTA and negative workup for other causes of sclerotic bone disease. A significant clinical and biochemical improvement, including recovery of proximal tubular dysfunction, was noted with alkali therapy. This case suggests the need to consider pSS in the diagnostic algorithm of a patient presenting with sclerotic bone disease.
Identifiants
pubmed: 33431459
pii: 14/1/e237987
doi: 10.1136/bcr-2020-237987
pmc: PMC7802734
pii:
doi:
Substances chimiques
Sodium Bicarbonate
8MDF5V39QO
Alkaline Phosphatase
EC 3.1.3.1
Potassium Citrate
EE90ONI6FF
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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