Auditory cues reveal intended movement information in middle frontal gyrus neuronal ensemble activity of a person with tetraplegia.
Acoustic Stimulation
Adult
Auditory Cortex
/ physiopathology
Brain-Computer Interfaces
Cues
Electrodes, Implanted
Frontal Lobe
/ physiopathology
Humans
Male
Microelectrodes
Movement
/ physiology
Neurons
/ physiology
Prefrontal Cortex
/ physiopathology
Quadriplegia
/ physiopathology
Self-Help Devices
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
11 01 2021
11 01 2021
Historique:
received:
21
07
2020
accepted:
12
11
2020
entrez:
12
1
2021
pubmed:
13
1
2021
medline:
31
7
2021
Statut:
epublish
Résumé
Intracortical brain-computer interfaces (iBCIs) allow people with paralysis to directly control assistive devices using neural activity associated with the intent to move. Realizing the full potential of iBCIs critically depends on continued progress in understanding how different cortical areas contribute to movement control. Here we present the first comparison between neuronal ensemble recordings from the left middle frontal gyrus (MFG) and precentral gyrus (PCG) of a person with tetraplegia using an iBCI. As expected, PCG was more engaged in selecting and generating intended movements than in earlier perceptual stages of action planning. By contrast, MFG displayed movement-related information during the sensorimotor processing steps preceding the appearance of the action plan in PCG, but only when the actions were instructed using auditory cues. These results describe a previously unreported function for neurons in the human left MFG in auditory processing contributing to motor control.
Identifiants
pubmed: 33431994
doi: 10.1038/s41598-020-77616-8
pii: 10.1038/s41598-020-77616-8
pmc: PMC7801741
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
98Subventions
Organisme : NIDCD NIH HHS
ID : R01 DC009899
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS)
ID : 1UH2NS095548
Organisme : NINDS NIH HHS
ID : DP2 NS111817
Pays : United States
Organisme : RRD VA
ID : I01 RX002295
Pays : United States
Organisme : NINDS NIH HHS
ID : UH2 NS095548
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS)
ID : U01NS098968-02
Organisme : U.S. Department of Health & Human Services | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD)
ID : R01DC009899
Organisme : NIDCD NIH HHS
ID : U01 DC017844
Pays : United States
Organisme : RRD VA
ID : I50 RX002864
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS)
ID : U01NS098968
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