Bifidobacterium bifidum strains synergize with immune checkpoint inhibitors to reduce tumour burden in mice.

Animals Bifidobacterium bifidum / classification Carcinoma, Non-Small-Cell Lung / drug therapy Drug Therapy, Combination Gastrointestinal Microbiome Humans Immune Checkpoint Inhibitors / therapeutic use Interferon-gamma / genetics Lung Neoplasms / drug therapy Metabolome / drug effects Mice Neoplasms, Experimental / drug therapy Probiotics / administration & dosage Species Specificity Transcriptome / drug effects Tryptophan / metabolism Tumor Burden / drug effects

Journal

Nature microbiology

ISSN: 2058-5276

Titre abrégé: Nat Microbiol

Pays: England

ID NLM: 101674869

Informations de publication

Date de publication:
03 2021

Historique:

received: 05 01 2020

accepted: 13 11 2020

pubmed: 13 1 2021

medline: 13 5 2021

entrez: 12 1 2021

Statut: ppublish

Résumé

The gut microbiome can influence the development of tumours and the efficacy of cancer therapeutics

Identifiants

DOI: 10.1038/s41564-020-00831-6 PMID: 33432149

pubmed: 33432149

doi: 10.1038/s41564-020-00831-6

pii: 10.1038/s41564-020-00831-6

doi:

Substances chimiques

Immune Checkpoint Inhibitors 0

Interferon-gamma 82115-62-6

Tryptophan 8DUH1N11BX

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

277-288

Commentaires et corrections

Type : CommentIn

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