Congenital anomalies in children with postneonatally acquired cerebral palsy: an international data linkage study.
Journal
Developmental medicine and child neurology
ISSN: 1469-8749
Titre abrégé: Dev Med Child Neurol
Pays: England
ID NLM: 0006761
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
accepted:
08
12
2020
pubmed:
13
1
2021
medline:
20
8
2021
entrez:
12
1
2021
Statut:
ppublish
Résumé
To describe the major congenital anomalies present in children with postneonatally acquired cerebral palsy (CP), and to compare clinical outcomes and cause of postneonatally acquired CP between children with and without anomalies. Data were linked between total population CP and congenital anomaly registers in five European and three Australian regions for children born 1991 to 2009 (n=468 children with postneonatally acquired CP; 255 males, 213 females). Data were pooled and children classified into mutually exclusive categories based on type of congenital anomaly. The proportion of children with congenital anomalies was calculated. Clinical outcomes and cause of postneonatally acquired CP were compared between children with and without anomalies. Major congenital anomalies were reported in 25.6% (95% confidence interval [CI] 21.7-29.9) of children with postneonatally acquired CP. Cardiac anomalies, often severe, were common and present in 14.5% of children with postneonatally acquired CP. Clinical outcomes were not more severe in children with congenital anomalies than those without anomalies. Cause of postneonatally acquired CP differed with the presence of congenital anomalies, with cerebrovascular accidents predominating in the anomaly group. Congenital anomalies were likely associated with cause of postneonatally acquired CP in 77% of children with anomalies. In this large, international study of children with postneonatally acquired CP, congenital anomalies (particularly cardiac anomalies) were common. Future research should determine specific causal pathways to postneonatally acquired CP that include congenital anomalies to identify opportunities for prevention. One-quarter of children with postneonatally acquired cerebral palsy (CP) have a major congenital anomaly. Cardiac anomalies, often severe, are the most common anomalies. Causes of postneonatally acquired CP differ between children with and without congenital anomalies.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
421-428Subventions
Organisme : National Health and Medical Research Council
ID : 1090648 (MH)
Organisme : National Health and Medical Research Council
ID : 1111270 (SM)
Organisme : National Health and Medical Research Council
ID : 1113806 (SG)
Organisme : National Health and Medical Research Council
ID : 1144566 (HSS)
Organisme : Cerebral Palsy Alliance Research Foundation
ID : PG1215
Organisme : Cerebral Palsy Alliance Research Foundation
ID : PG2816
Investigateurs
Ingeborg Barisic
(I)
Vlatka Bosnjak Mejaski
(V)
Emmanuelle Amar
(E)
Elodie Sellier
(E)
Sandra Julsen Hollung
(SJ)
Kari Klungsøyr
(K)
Paula Braz
(P)
Daniel Virella
(D)
Catherine Gibson
(C)
Karin Källén
(K)
Susan M Reid
(SM)
Gareth Baynam
(G)
Dylan Gration
(D)
Michèle Hansen
(M)
Linda Watson
(L)
Informations de copyright
© 2021 Mac Keith Press.
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