Nosology of Primary Progressive Aphasia and the Neuropathology of Language.

Alzheimer Asymmetry Broca Grammar Language Naming Selective vulnerability Wernicke Word comprehension

Journal

Advances in experimental medicine and biology
ISSN: 0065-2598
Titre abrégé: Adv Exp Med Biol
Pays: United States
ID NLM: 0121103

Informations de publication

Date de publication:
2021
Historique:
entrez: 12 1 2021
pubmed: 13 1 2021
medline: 16 2 2021
Statut: ppublish

Résumé

Primary progressive aphasia (PPA) is a dementia syndrome associated with several neuropathologic entities, including Alzheimer's disease (AD) and all major forms of frontotemporal lobar degeneration (FTLD). It is classified into subtypes defined by the nature of the language domain that is most impaired. The asymmetric neurodegeneration of the hemisphere dominant for language (usually left) is one consistent feature of all PPA variants. This feature offers unique opportunities for exploring mechanisms of selective vulnerability in neurodegenerative diseases and the neuroanatomy of language. This chapter reviews some of the current trends in PPA research as well as the challenges that remain to be addressed on the nosology, clinicopathologic correlations, and therapy of this syndrome.

Identifiants

pubmed: 33433867
doi: 10.1007/978-3-030-51140-1_3
pmc: PMC8103786
mid: NIHMS1689011
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

33-49

Subventions

Organisme : NIDCD NIH HHS
ID : R01 DC008552
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS075075
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG072977
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG062566
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS085770
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG013854
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG056258
Pays : United States

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Auteurs

M -Marsel Mesulam (M-)

Mesulam Center for Cognitive Neurology and Alzheimer's Disease; Department of Neurology, Northwestern University, Chicago, IL, USA. mmesulam@northwestern.edu.

Christina Coventry (C)

Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University, Chicago, IL, USA.

Eileen H Bigio (EH)

Mesulam Center for Cognitive Neurology and Alzheimer's Disease; Department of Pathology, Northwestern University, Chicago, IL, USA.

Changiz Geula (C)

Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University, Chicago, IL, USA.

Cynthia Thompson (C)

Mesulam Center for Cognitive Neurology and Alzheimer's Disease; Department of Communication Sciences and Disorders; Department of Neurology, Northwestern University, Evanston, IL, USA.

Borna Bonakdarpour (B)

Mesulam Center for Cognitive Neurology and Alzheimer's Disease; Department of Neurology, Northwestern University, Chicago, IL, USA.

Tamar Gefen (T)

Mesulam Center for Cognitive Neurology and Alzheimer's Disease; Department of Psychiatry, Northwestern University, Chicago, IL, USA.

Emily J Rogalski (EJ)

Mesulam Center for Cognitive Neurology and Alzheimer's Disease; Department of Psychiatry, Northwestern University, Chicago, IL, USA.

Sandra Weintraub (S)

Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University, Chicago, IL, USA.

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