Sleep deprivation did not enhance the success rate of chloral hydrate sedation for non-invasive procedural sedation in pediatric patients.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2021
2021
Historique:
received:
02
09
2020
accepted:
28
12
2020
entrez:
12
1
2021
pubmed:
13
1
2021
medline:
16
6
2021
Statut:
epublish
Résumé
In Asian countries, oral chloral hydrate is the most commonly used sedative for non-invasive procedures. Theoretically, mild sleep deprivation could be considered as one of assisted techniques. However, there is no consensus on sleep deprivation facilitating the sedation during non-painful procedures in children. The aim of our study is to analyze the clinical data of children undergoing non-invasive procedural sedation retrospectively and to evaluate the association between mild sleep deprivation and sedative effects in non-invasive procedures. Consecutive patients undergoing chloral hydrate sedation for non-invasive procedures between December 1, 2019 to June 30, 2020 were included in this study. The propensity score analysis with 1: 1 ratio was used to match the baseline variables between patients with sleep deprivation and non-sleep deprivation. The primary outcome was the failure rate of sedation with the initial dose. The secondary outcomes included the failure rate of sedation after supplementation of chloral hydrate, the incidence of major and minor adverse events, initial and supplemental dose of chloral hydrate, and the length of sedation time. Of the 7789 patients undergoing chloral hydrate sedation, 6352 were treated with sleep deprivation and 1437 with non-sleep deprivation. After propensity score matching, 1437 pairs were produced. The failure rate of sedation with initial chlorate hydrate was not significantly different in two groups (8.6% [123/1437] vs. 10.6% [152/1437], p = 0.08), nor were the failure rates with supplemental chlorate hydrate (0.8% [12/1437] vs. 0.9% [13/1437], p = 1) and the length of sedation time (58 [45, 75] vs. 58 [45, 75] min; p = 0.93). The current results do not support sleep deprivation have a beneficial effect in reducing the pediatric chloral hydrate sedation failure rate. The routine use of sleep deprivation for pediatric sedation is unnecessary.
Identifiants
pubmed: 33434236
doi: 10.1371/journal.pone.0245338
pii: PONE-D-20-26402
pmc: PMC7802942
doi:
Substances chimiques
Hypnotics and Sedatives
0
Chloral Hydrate
418M5916WG
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0245338Déclaration de conflit d'intérêts
No authors have competing interests.
Références
Environ Health Perspect. 2006 Sep;114(9):1457-63
pubmed: 16966105
Eur Respir J. 1996 May;9(5):932-8
pubmed: 8793454
Int J Pediatr Otorhinolaryngol. 2016 Apr;83:175-8
pubmed: 26968073
Lancet. 2006 Mar 4;367(9512):766-80
pubmed: 16517277
Pediatrics. 2004 May;113(5):1204-8
pubmed: 15121930
Paediatr Anaesth. 2019 Jun;29(6):583-590
pubmed: 30793427
Am J Ophthalmol. 2018 Aug;192:39-46
pubmed: 29753853
Acta Anaesthesiol Scand. 2020 Apr;64(4):464-471
pubmed: 31736052
Clin Neurophysiol. 2004 Apr;115(4):951-5
pubmed: 15003778
Br J Ophthalmol. 2017 Oct;101(10):1423-1430
pubmed: 28242616
Emerg Med J. 2013 Mar;30(3):e24
pubmed: 22518059
J Pediatr Ophthalmol Strabismus. 2014 May-Jun;51(3):154-9
pubmed: 24627951
Am J Emerg Med. 2019 Jan;37(1):85-88
pubmed: 29730093