Rethinking the Citric Acid Cycle: Connecting Pyruvate Carboxylase and Citrate Synthase to the Flow of Energy and Material.
Citric Acid Cycle
exercise
malic acid
memory formation
oxidative phosphorylation
succinic acid
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
09 Jan 2021
09 Jan 2021
Historique:
received:
16
12
2020
revised:
06
01
2021
accepted:
07
01
2021
entrez:
13
1
2021
pubmed:
14
1
2021
medline:
8
9
2021
Statut:
epublish
Résumé
In 1937, Sir H. A Krebs first published the Citric Acid Cycle, a unidirectional cycle with carboxylic acids. The original concept of the Citric Acid Cycle from Krebs' 1953 Nobel Prize lecture illustrates the unidirectional degradation of lactic acid to water, carbon dioxide and hydrogen. Here, we add the heart lactate dehydrogenase•proton-linked monocarboxylate transporter 1 complex, connecting the original Citric Acid Cycle to the flow of energy and material. The heart lactate dehydrogenase•proton-linked monocarboxylate transporter 1 complex catalyses the first reaction of the Citric Acid Cycle, the oxidation of lactate to pyruvate, and thus secures the provision of pyruvic acid. In addition, we modify Krebs' original concept by feeding the cycle with oxaloacetic acid. Our concept enables the integration of anabolic processes and allows adaption of the organism to recover ATP faster.
Identifiants
pubmed: 33435350
pii: ijms22020604
doi: 10.3390/ijms22020604
pmc: PMC7827294
pii:
doi:
Substances chimiques
Monocarboxylic Acid Transporters
0
Protons
0
Symporters
0
monocarboxylate transport protein 1
0
L-Lactate Dehydrogenase
EC 1.1.1.27
Citrate (si)-Synthase
EC 2.3.3.1
Pyruvate Carboxylase
EC 6.4.1.1
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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