Activation and Monitoring of mtDNA Damage in Cancer Cells via the "Proton-Triggered" Decomposition of an Ultrathin Nanosheet.

Biosensing Techniques / methods Calcium / chemistry Cell Line DNA Damage / drug effects DNA, Mitochondrial / genetics Durapatite / chemistry Hep G2 Cells Humans Nanostructures / chemistry Protons
cancer cell hydroxyapatite mtDNA damage proton-triggered ultrathin nanosheet

Journal

ACS applied materials & interfaces
ISSN: 1944-8252
Titre abrégé: ACS Appl Mater Interfaces
Pays: United States
ID NLM: 101504991

Informations de publication

Date de publication:
27 Jan 2021
Historique:
pubmed: 14 1 2021
medline: 3 3 2021
entrez: 13 1 2021
Statut: ppublish

Résumé

Mitochondrial DNA (mtDNA) damage is a very important molecular event, which has significant effects on living organisms. Therefore, a particularly important challenge for biomaterials research is to develop functionalized nanoparticles that can activate and monitor mtDNA damage and instigate cancer cell apoptosis, and as such eliminate the negative effects on living organisms. Toward that goal, with this research, we have developed a hydroxyapatite ultrathin nanosheet (

Identifiants

DOI: 10.1021/acsami.0c20060 PMID: 33435678
pubmed: 33435678
doi: 10.1021/acsami.0c20060
doi:

Substances chimiques

DNA, Mitochondrial 0
Protons 0
Durapatite 91D9GV0Z28
Calcium SY7Q814VUP

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3669-3678

Auteurs

Jun W Liu (JW)

Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, School of Physics, School of Environment, Henan Normal University, Xinxiang, Henan 453007, China.

Yong G Yang (YG)

Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, School of Physics, School of Environment, Henan Normal University, Xinxiang, Henan 453007, China.

Kui Wang (K)

Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, School of Physics, School of Environment, Henan Normal University, Xinxiang, Henan 453007, China.

Ge Wang (G)

School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan 453003, China.

Cong C Shen (CC)

Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, School of Physics, School of Environment, Henan Normal University, Xinxiang, Henan 453007, China.

Yue H Chen (YH)

Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, School of Physics, School of Environment, Henan Normal University, Xinxiang, Henan 453007, China.

Yu F Liu (YF)

Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, School of Physics, School of Environment, Henan Normal University, Xinxiang, Henan 453007, China.
ORCID: 0000-0003-1896-8864

Tony D James (TD)

Department of Chemistry, University of Bath, Bath BA2 7AY, U.K.
ORCID: 0000-0002-4095-2191

Kai Jiang (K)

Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, School of Physics, School of Environment, Henan Normal University, Xinxiang, Henan 453007, China.

Hua Zhang (H)

Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, School of Physics, School of Environment, Henan Normal University, Xinxiang, Henan 453007, China.
ORCID: 0000-0002-7593-4946

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Techniques de biocapteur › Activation and Monitoring of mtDNA Damage in...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Activation and Monitoring of mtDNA Damage in...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Activation and Monitoring of mtDNA Damage in...
questionsmedicales.fr › Phénomènes génétiques › Altération de l'ADN › Activation and Monitoring of mtDNA Damage in...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › ADN mitochondrial › Activation and Monitoring of mtDNA Damage in...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du phosphore › Acides du phosphore › Acides phosphoriques › Phosphates › Phosphates de calcium › Apatites › Hydroxyapatites › Durapatite › Activation and Monitoring of mtDNA Damage in...
questionsmedicales.fr › Cellules › Cellules épithéliales › Hépatocytes › Cellules HepG2 › Activation and Monitoring of mtDNA Damage in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Activation and Monitoring of mtDNA Damage in...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Activation and Monitoring of mtDNA Damage in...
questionsmedicales.fr › Phénomènes physiques › Particules élémentaires › Nucléons › Protons › Activation and Monitoring of mtDNA Damage in...