The elastin peptide VGVAPG increases CD4
COPD
Cytokines
Elastin peptides
Flow cytometry
IL-4
T cells
Journal
Respiratory research
ISSN: 1465-993X
Titre abrégé: Respir Res
Pays: England
ID NLM: 101090633
Informations de publication
Date de publication:
13 Jan 2021
13 Jan 2021
Historique:
received:
24
09
2020
accepted:
22
12
2020
entrez:
13
1
2021
pubmed:
14
1
2021
medline:
9
10
2021
Statut:
epublish
Résumé
In chronic obstructive pulmonary disease (COPD), lung-infiltrating inflammatory cells secrete proteases and participate in elastin breakdown and genesis of elastin-derived peptides (EP). In the present study, we hypothesized that the pattern of T lymphocytes cytokine expression may be modulated by EP in COPD patients. CD4 Compared with control, the percentage of IL-4 (Th2) producing CD4 The present study demonstrates that the VGVAPG elastin peptide modulates CD4
Sections du résumé
BACKGROUND
BACKGROUND
In chronic obstructive pulmonary disease (COPD), lung-infiltrating inflammatory cells secrete proteases and participate in elastin breakdown and genesis of elastin-derived peptides (EP). In the present study, we hypothesized that the pattern of T lymphocytes cytokine expression may be modulated by EP in COPD patients.
METHODS
METHODS
CD4
RESULTS
RESULTS
Compared with control, the percentage of IL-4 (Th2) producing CD4
CONCLUSIONS
CONCLUSIONS
The present study demonstrates that the VGVAPG elastin peptide modulates CD4
Identifiants
pubmed: 33435988
doi: 10.1186/s12931-020-01609-4
pii: 10.1186/s12931-020-01609-4
pmc: PMC7805078
doi:
Substances chimiques
IL4 protein, human
0
Oligopeptides
0
Interleukin-4
207137-56-2
valyl-glycyl-valyl-alanyl-prolyl-glycine
92899-39-3
Types de publication
Clinical Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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