Differential effects of sodium chloride and monosodium glutamate on kidney of adult and aging mice.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
12 01 2021
12 01 2021
Historique:
received:
30
10
2019
accepted:
11
12
2020
entrez:
13
1
2021
pubmed:
14
1
2021
medline:
7
8
2021
Statut:
epublish
Résumé
Monosodium Glutamate (MSG) is used as flavour enhancer, with potential beneficial effects due to its nutritional value. Given the decline in kidney functions during aging, we investigated the impact of MSG voluntary intake on the kidney of male mice, aged 6 or 18 months. For 2 months, they freely consumed water (control group), sodium chloride (0.3% NaCl) or MSG (1% MSG) in addition to standard diet. Young animals consuming sodium chloride presented signs of proteinuria, hyperfiltration, enhanced expression and excretion of Aquaporin 2 and initial degenerative reactions suggestive of fibrosis, while MSG-consuming mice were similar to controls. In old mice, aging-related effects including proteinuria and increased renal corpuscle volume were observed in all groups. At an advanced age, MSG caused no adverse effects on the kidney compared to controls, despite the presence of a sodium moiety, similar to sodium chloride. These data show that prolonged MSG intake in mice has less impact on kidney compared to sodium chloride, that already in young animals induced some effects on kidney, possibly related to hypertension.
Identifiants
pubmed: 33436880
doi: 10.1038/s41598-020-80048-z
pii: 10.1038/s41598-020-80048-z
pmc: PMC7804302
doi:
Substances chimiques
Sodium Chloride
451W47IQ8X
Sodium Glutamate
W81N5U6R6U
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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