Fetal neurosonography detects differences in cortical development and corpus callosum in late-onset small fetuses.
Birth Weight
Cerebral Cortex
/ diagnostic imaging
Corpus Callosum
/ diagnostic imaging
Female
Fetal Development
Fetal Growth Retardation
/ diagnostic imaging
Fetal Weight
Gestational Age
Humans
Infant, Newborn
Infant, Small for Gestational Age
/ growth & development
Linear Models
Male
Neuroimaging
/ methods
Pregnancy
Prospective Studies
Sensitivity and Specificity
Ultrasonography, Doppler
/ methods
Ultrasonography, Prenatal
/ methods
brain
cortical development
fetal growth restriction
magnetic resonance imaging
neurosonography
small-for-gestational age
Journal
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
ISSN: 1469-0705
Titre abrégé: Ultrasound Obstet Gynecol
Pays: England
ID NLM: 9108340
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
revised:
17
11
2020
received:
04
09
2020
accepted:
24
12
2020
pubmed:
14
1
2021
medline:
15
12
2021
entrez:
13
1
2021
Statut:
ppublish
Résumé
To explore whether neurosonography can detect differences in cortical development and corpus callosal length in late-onset small fetuses subclassified into small-for-gestational age (SGA) or growth restricted (FGR). This was a prospective cohort study in singleton pregnancies, including normally grown fetuses (birth weight between the 10 In total, 318 fetuses were included, of which 97 were normally grown and 221 were late-onset small fetuses that were further subdivided into late-onset SGA (n = 67) or late-onset FGR (n = 154). Compared to controls, both SGA and FGR cases showed significantly increased insular depth adjusted for biparietal diameter (median (interquartile range), controls 0.329 (0.312-0.342) vs SGA 0.339 (0.321-0.347) vs FGR 0.336 (0.325-0.349); P = 0.006). A linear tendency to reduced Sylvian fissure depth adjusted for biparietal diameter was also observed across the study groups (mean ± SD, controls 0.148 ± 0.021 vs SGA 0.142 ± 0.025 vs FGR 0.139 ± 0.022; P = 0.003). However, differences were significant only between the FGR and control groups. Corpus callosal length adjusted for cephalic index was significantly reduced in FGR cases compared with both controls and SGA cases, while there was no difference between SGA cases and controls (median (interquartile range), controls 0.500 (0.478-0.531) vs SGA 0.502 (0.487-0.526) vs FGR 0.475 (0.447-0.508); P = 0.005). No differences were found in parieto-occipital sulcus depth between the three study groups. Neurosonography seems to be a sensitive tool to detect subtle structural differences in brain development in late-onset small fetuses. © 2021 International Society of Ultrasound in Obstetrics and Gynecology.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
42-47Subventions
Organisme : "Fundació Dexeus Mujer"
ID : grant "Fundació Dexeus Mujer"
Organisme : "LaCaixa" Foundation
ID : LCF/PR/GN14/10270005 and LCF/PR/GN18/10310003 and
Organisme : Departament de Salut
ID : SLT008/18/00156
Organisme : Erasmus + Programme of the European Union
ID : 2013-0040
Organisme : Fundação para a Ciência e Tecnologia
ID : SFRH/SINTD/92997/2013
Organisme : Instituto de Salud Carlos III
ID : PI13/01018, INT16/00168, PI14/00226, PIE15/00027,
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2021 International Society of Ultrasound in Obstetrics and Gynecology.
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