Improved Oral Bioavailability and Hypolipidemic Effect of Syringic Acid via a Self-microemulsifying Drug Delivery System.
Administration, Oral
Animals
Biological Availability
Cell Line
Drug Delivery Systems
Drug Liberation
Emulsions
/ administration & dosage
Gallic Acid
/ administration & dosage
Humans
Hypolipidemic Agents
/ administration & dosage
Male
Mice
Mice, Inbred ICR
Rats
Rats, Sprague-Dawley
Surface-Active Agents
/ chemistry
controlled release
hypolipidemic effect
oral bioavailability
self-microemulsifying drug delivery system (SMEDDS)
syringic acid
Journal
AAPS PharmSciTech
ISSN: 1530-9932
Titre abrégé: AAPS PharmSciTech
Pays: United States
ID NLM: 100960111
Informations de publication
Date de publication:
13 Jan 2021
13 Jan 2021
Historique:
received:
10
09
2020
accepted:
07
12
2020
entrez:
13
1
2021
pubmed:
14
1
2021
medline:
20
2
2021
Statut:
epublish
Résumé
This study aimed to develop a self-microemulsifying drug delivery system (SMEDDS) to enhance the solubility, oral bioavailability, and hypolipidemic effects of syringic acid (SA), a bioactive and poorly-soluble polyphenol. Based on the response surface methodology-central composite design (RSM-CCD), an optimum formulation of SA-SMEDDS, consisting of ethyl oleate (oil, 12.30%), Cremophor-EL (surfactant, 66.25%), 1,2-propanediol (cosurfactant, 21.44%), and drug loading (50 mg/g), was obtained. The droplets of SA-SMEDDS were nanosized (16.38 ± 0.12 nm), spherically shaped, and homogeneously distributed (PDI = 0.058 ± 0.013) nanoparticles with high encapsulation efficiency (98.04 ± 1.39%) and stability. In vitro release study demonstrated a prolonged and controlled release of SA from SMEDDS. In vitro cell studies signified that SA-SMEDDS droplets substantially promoted cellular internalization. In comparison with the SA suspension, SA-SMEDDS showed significant prolonged T
Identifiants
pubmed: 33439366
doi: 10.1208/s12249-020-01901-y
pii: 10.1208/s12249-020-01901-y
doi:
Substances chimiques
Emulsions
0
Hypolipidemic Agents
0
Surface-Active Agents
0
Gallic Acid
632XD903SP
syringic acid
E390O181H5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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