Fucoidan Structure and Its Impact on Glucose Metabolism: Implications for Diabetes and Cancer Therapy.
anticancer
antidiabetic
fucoidan
glucose metabolism
natural bioproducts
Journal
Marine drugs
ISSN: 1660-3397
Titre abrégé: Mar Drugs
Pays: Switzerland
ID NLM: 101213729
Informations de publication
Date de publication:
11 Jan 2021
11 Jan 2021
Historique:
received:
14
12
2020
revised:
31
12
2020
accepted:
07
01
2021
entrez:
14
1
2021
pubmed:
15
1
2021
medline:
20
5
2021
Statut:
epublish
Résumé
Fucoidans are complex polysaccharides derived from brown seaweeds which consist of considerable proportions of L-fucose and other monosaccharides, and sulphated ester residues. The search for novel and natural bioproduct drugs (due to toxicity issues associated with chemotherapeutics) has led to the extensive study of fucoidan due to reports of it having several bioactive characteristics. Among other fucoidan bioactivities, antidiabetic and anticancer properties have received the most research attention in the past decade. However, the elucidation of the fucoidan structure and its biological activity is still vague. In addition, research has suggested that there is a link between diabetes and cancer; however, limited data exist where dual chemotherapeutic efforts are elucidated. This review provides an overview of glucose metabolism, which is the central process involved in the progression of both diseases. We also highlight potential therapeutic targets and show the relevance of fucoidan and its derivatives as a candidate for both cancer and diabetes therapy.
Identifiants
pubmed: 33440853
pii: md19010030
doi: 10.3390/md19010030
pmc: PMC7826564
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Hypoglycemic Agents
0
Polysaccharides
0
fucoidan
9072-19-9
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutscher Akademischer Austauschdienst
ID : In-Region Scholarship
Organisme : Pearson Young Memorial Scholarship
ID : Chantal Daub
Organisme : Henderson Scholarship
ID : Chantal Daub
Organisme : National Research Foundation
ID : Chantal Daub
Références
Bull Exp Biol Med. 2007 Jun;143(6):730-2
pubmed: 18239813
Mar Drugs. 2015 Sep 24;13(10):6099-116
pubmed: 26404322
Carbohydr Res. 2011 Dec 13;346(17):2769-76
pubmed: 22024567
Biophys J. 2011 Jan 5;100(1):52-9
pubmed: 21190656
Physiol Genomics. 2011 Mar 16;43(5):255-64
pubmed: 21177384
Phytother Res. 2011 Jul;25(7):1082-6
pubmed: 21452391
Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):489-94
pubmed: 23267074
Carbohydr Res. 2019 Nov 1;485:107806
pubmed: 31526929
Int J Biol Macromol. 2016 Jan;82:249-55
pubmed: 26601762
Lancet. 2014 Jan 4;383(9911):69-82
pubmed: 23890997
Indian J Pharm Sci. 2012 Nov;74(6):549-55
pubmed: 23798781
J Nat Prod. 2011 Sep 23;74(9):1851-61
pubmed: 21875034
Pharmacol Res. 2019 Dec;150:104511
pubmed: 31678210
Biomol Ther (Seoul). 2015 May;23(3):225-32
pubmed: 25995820
Genes Dis. 2017 Feb 14;4(1):25-27
pubmed: 30258905
Cell Syst. 2018 Jul 25;7(1):49-62.e8
pubmed: 29960885
Cancer Cell. 2013 Jun 10;23(6):811-25
pubmed: 23764003
Cell Cycle. 2013 Nov 15;12(22):3490-9
pubmed: 24240433
Radiother Oncol. 2009 Sep;92(3):329-33
pubmed: 19604589
Lancet Oncol. 2001 Mar;2(3):157-64
pubmed: 11902566
Clin Cancer Res. 2015 Mar 1;21(5):1161-71
pubmed: 25542900
Ther Clin Risk Manag. 2014 Jun 30;10:505-11
pubmed: 25061309
J Agric Food Chem. 2009 Sep 23;57(18):8677-82
pubmed: 19754176
Nat Rev Cancer. 2004 Nov;4(11):891-9
pubmed: 15516961
Cancer Chemother Pharmacol. 2013 Feb;71(2):523-30
pubmed: 23228990
Mar Drugs. 2015 Sep 16;13(9):5920-46
pubmed: 26389927
Diabetologia. 2017 Sep;60(9):1577-1585
pubmed: 28776086
Korean J Radiol. 2009 Nov-Dec;10(6):596-603
pubmed: 19885316
Mar Drugs. 2017 Feb 15;15(2):
pubmed: 28212301
Lancet Diabetes Endocrinol. 2016 Jun;4(6):525-36
pubmed: 26876794
Int J Biol Macromol. 2013 Sep;60:366-74
pubmed: 23817097
Cancer Biol Ther. 2013 Feb;14(2):81-9
pubmed: 23192270
Biomed Res Int. 2014;2014:783895
pubmed: 25050371
Mar Drugs. 2019 Jan 07;17(1):
pubmed: 30621045
PLoS One. 2016 Sep 26;11(9):e0163768
pubmed: 27669567
Nutr Res. 2019 May;65:54-62
pubmed: 30952503
PLoS One. 2014 Feb 26;9(2):e89977
pubmed: 24587162
Biomaterials. 2014 Feb;35(5):1597-607
pubmed: 24290441
Int J Obes Relat Metab Disord. 2002 Jul;26(7):897-904
pubmed: 12080441
Diabetes. 2019 May;68(5):897-900
pubmed: 31010881
Mar Drugs. 2011 Dec;9(12):2605-21
pubmed: 22363242
J Nucl Med. 2010 Jan;51(1):25-30
pubmed: 20009002
Mar Drugs. 2015 Apr 14;13(4):2327-46
pubmed: 25874926
Appl Biochem Biotechnol. 2011 Jul;164(6):841-50
pubmed: 21302149
J Diabetes Investig. 2017 Aug 8;:
pubmed: 28786562
J Neurochem. 2018 Jan;144(1):93-104
pubmed: 29105080
Clin Cancer Res. 2004 Oct 1;10(19):6661-8
pubmed: 15475456
Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18868-73
pubmed: 20921411
Bioorg Med Chem. 2009 Mar 1;17(5):1783-802
pubmed: 19217790
PLoS Biol. 2012;10(5):e1001326
pubmed: 22589701
Science. 2009 May 22;324(5930):1029-33
pubmed: 19460998
PLoS One. 2015 Mar 25;10(3):e0121046
pubmed: 25807077
Cell Metab. 2015 Jan 6;21(1):11-2
pubmed: 25565201
Molecules. 2008 Aug 12;13(8):1671-95
pubmed: 18794778
Curr Top Med Chem. 2018;18(6):494-504
pubmed: 29788892
Int J Biol Macromol. 2020 May 15;151:412-420
pubmed: 32070744
Signal Transduct Target Ther. 2017 Mar 10;2:16047
pubmed: 29263910
Diabetes Care. 2010 Jul;33(7):1674-85
pubmed: 20587728
J Bioenerg Biomembr. 2012 Feb;44(1):127-39
pubmed: 22407107
J Exp Biol. 2011 Jan 15;214(Pt 2):254-62
pubmed: 21177945
Cell. 2017 May 4;169(4):570-586
pubmed: 28475890
Clin Biochem Rev. 2005 May;26(2):19-39
pubmed: 16278749
Front Pharmacol. 2020 Jun 05;11:831
pubmed: 32581797
Curr Opin Genet Dev. 2008 Feb;18(1):54-61
pubmed: 18387799
Cancer. 1987 Dec 1;60(11):2682-9
pubmed: 3499969
J Mol Med (Berl). 2016 Feb;94(2):155-71
pubmed: 26099350
Diabetes. 2017 Feb;66(2):241-255
pubmed: 27980006
Int J Biol Macromol. 2015 Jan;72:1044-7
pubmed: 25453283
Yonago Acta Med. 2019 Mar 28;62(1):14-23
pubmed: 30962740
Oncogene. 2006 Aug 7;25(34):4683-96
pubmed: 16892082
IUBMB Life. 2012 Jan;64(1):1-9
pubmed: 22131303
Food Chem Toxicol. 2014 Feb;64:344-52
pubmed: 24333868
BMC Biol. 2010 Jun 25;8:88
pubmed: 20598111
Mar Drugs. 2015 Jul 17;13(7):4436-51
pubmed: 26193287
Mar Drugs. 2016 Apr 15;14(4):
pubmed: 27092514
Mar Drugs. 2018 Sep 09;16(9):
pubmed: 30205616
J Clin Invest. 1988 May;81(5):1563-71
pubmed: 3130396
Invest New Drugs. 2014 Jun;32(3):452-64
pubmed: 24297161
Am J Physiol Endocrinol Metab. 2014 Nov 15;307(10):E859-71
pubmed: 25205823
Am J Physiol. 1988 Dec;255(6 Pt 1):E769-74
pubmed: 3059816
Mar Drugs. 2020 May 22;18(5):
pubmed: 32456047
Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2037-42
pubmed: 20133848
J Biosci Bioeng. 2016 Jan;121(1):36-42
pubmed: 26194305
Expert Opin Ther Targets. 2018 Apr;22(4):295-298
pubmed: 29517391
Mol Biol Cell. 2015 Sep 15;26(18):3129-39
pubmed: 26371080
Mol Aspects Med. 2015 Dec;46:21-33
pubmed: 26549348
Nutrients. 2016 Jan 14;8(1):
pubmed: 26784222
J Agric Food Chem. 2016 Sep 14;64(36):6826-37
pubmed: 27538679
Mol Med Rep. 2015 Sep;12(3):3446-3452
pubmed: 25998232
Cells. 2018 Mar 13;7(3):
pubmed: 29534029
Mar Drugs. 2018 Jun 04;16(6):
pubmed: 29867001
J Cancer. 2017 Sep 20;8(17):3430-3440
pubmed: 29151926
Phytochemistry. 2014 Feb;98:27-33
pubmed: 24388677
Cancer Cell Int. 2020 May 7;20:154
pubmed: 32410882
Int J Biol Macromol. 2007 Aug 1;41(3):221-6
pubmed: 17433432
Mar Drugs. 2019 Mar 20;17(3):
pubmed: 30897733
PLoS One. 2012;7(10):e46571
pubmed: 23082126
Adv Physiol Educ. 2010 Jun;34(2):44-53
pubmed: 20522896