Asthma in elderly is characterized by increased sputum neutrophils, lower airway caliber variability and air trapping.
Aging
Air trapping
Airway caliber
Asthma
Eosinophils
Hyperresponsiveness
Neutrophils
Sputum
Journal
Respiratory research
ISSN: 1465-993X
Titre abrégé: Respir Res
Pays: England
ID NLM: 101090633
Informations de publication
Date de publication:
13 Jan 2021
13 Jan 2021
Historique:
received:
04
05
2020
accepted:
07
01
2021
entrez:
14
1
2021
pubmed:
15
1
2021
medline:
30
1
2021
Statut:
epublish
Résumé
Elderly asthmatics represent an important group that is often excluded from clinical studies. In this study we wanted to present characteristics of asthmatics older than 70 years old as compared to younger patients. We conducted a retrospective analysis on a series of 758 asthmatics subdivided in three groups: lower than 40, between 40 and 70 and older than 70. All the patients who had a successful sputum induction were included in the study. Older patients had a higher Body Mass Index, had less active smokers and were more often treated with Long Acting anti-Muscarinic Agents. We found a significant increase in sputum neutrophil counts with ageing. There was no significant difference in blood inflammatory cell counts whatever the age group. Forced expiratory volume in one second (FEV Our study highlights that asthmatics older than 70 years old have higher bronchial neutrophilic inflammation, a poorer lung function, signs of air trapping and lower airway variability. The role of immunosenescence inducing chronic low-grade inflammation in this asthma subtype remains to be elucidated.
Sections du résumé
BACKGROUND
BACKGROUND
Elderly asthmatics represent an important group that is often excluded from clinical studies. In this study we wanted to present characteristics of asthmatics older than 70 years old as compared to younger patients.
METHODS
METHODS
We conducted a retrospective analysis on a series of 758 asthmatics subdivided in three groups: lower than 40, between 40 and 70 and older than 70. All the patients who had a successful sputum induction were included in the study.
RESULTS
RESULTS
Older patients had a higher Body Mass Index, had less active smokers and were more often treated with Long Acting anti-Muscarinic Agents. We found a significant increase in sputum neutrophil counts with ageing. There was no significant difference in blood inflammatory cell counts whatever the age group. Forced expiratory volume in one second (FEV
CONCLUSION
CONCLUSIONS
Our study highlights that asthmatics older than 70 years old have higher bronchial neutrophilic inflammation, a poorer lung function, signs of air trapping and lower airway variability. The role of immunosenescence inducing chronic low-grade inflammation in this asthma subtype remains to be elucidated.
Identifiants
pubmed: 33441106
doi: 10.1186/s12931-021-01619-w
pii: 10.1186/s12931-021-01619-w
pmc: PMC7805110
doi:
Substances chimiques
Inflammation Mediators
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
15Subventions
Organisme : Belgian Federal Science Policy Office
ID : EOS project 30565447
Références
Thorax. 2004 Feb;59(2):111-5
pubmed: 14760148
Clin Exp Immunol. 2005 Jun;140(3):540-6
pubmed: 15932517
Exp Gerontol. 2009 Aug;44(8):511-6
pubmed: 19457449
Eur Respir J. 1999 Oct;14(4):902-7
pubmed: 10573240
J Breath Res. 2015 May 20;9(3):036005
pubmed: 25993061
Rev Mal Respir. 1993;10(5):423-31
pubmed: 8256028
Eur Respir J. 2003 Sep;22(3):484-90
pubmed: 14516139
Am J Respir Crit Care Med. 2002 Apr 1;165(7):904-10
pubmed: 11934712
Allergy Asthma Immunol Res. 2020 May;12(3):443-453
pubmed: 32141258
Nat Rev Endocrinol. 2018 Oct;14(10):576-590
pubmed: 30046148
Allergy Asthma Proc. 2004 Sep-Oct;25(5):321-5
pubmed: 15603205
J Allergy Clin Immunol. 2005 Nov;116(5):961-8; quiz 969
pubmed: 16275361
Eur Respir J. 1994 Jun;7(6):1077-83
pubmed: 7925876
BMC Pulm Med. 2013 Feb 26;13:11
pubmed: 23442497
Thorax. 1992 Feb;47(2):76-83
pubmed: 1549827
Pediatr Pulmonol. 2009 May;44(5):503-11
pubmed: 19382221
Allergy. 2002 Oct;57(10):907-12
pubmed: 12269936
J Allergy Clin Immunol. 2001 Nov;108(5):753-8
pubmed: 11692100
Int Arch Allergy Immunol. 2014;165(1):61-7
pubmed: 25342531
Asian Pac J Allergy Immunol. 1996 Jun;14(1):1-4
pubmed: 8980792
Aging Cell. 2014 Aug;13(4):690-8
pubmed: 24779584
Biogerontology. 2015 Apr;16(2):187-201
pubmed: 25009085
Clin Interv Aging. 2015 Jun 16;10:963-7
pubmed: 26124649
Ageing Res Rev. 2020 Aug;61:101071
pubmed: 32344191
J Investig Allergol Clin Immunol. 2011;21(3):199-206
pubmed: 21548448