The intratumoral CXCR3 chemokine system is predictive of chemotherapy response in human bladder cancer.

CD8-Positive T-Lymphocytes Chemokine CXCL10 / therapeutic use Chemokine CXCL11 / therapeutic use Chemokines Chemotherapy, Adjuvant Humans Neoadjuvant Therapy Receptors, CXCR3 Urinary Bladder Neoplasms / drug therapy

Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
13 01 2021
Historique:
received: 19 02 2020
revised: 23 07 2020
accepted: 14 10 2020
entrez: 14 1 2021
pubmed: 15 1 2021
medline: 13 7 2021
Statut: ppublish

Résumé

Chemotherapy has direct toxic effects on cancer cells; however, long-term cancer control and complete remission are likely to involve CD8

Identifiants

DOI: 10.1126/scitranslmed.abb3735 PMID: 33441425
pubmed: 33441425
pii: 13/576/eabb3735
doi: 10.1126/scitranslmed.abb3735
pii:
doi:

Substances chimiques

CXCR3 protein, human 0
Chemokine CXCL10 0
Chemokine CXCL11 0
Chemokines 0
Receptors, CXCR3 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Commentaires et corrections

Type : CommentIn
Type : CommentIn

Informations de copyright

Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Auteurs

Tino Vollmer (T)

Institute of Medical Immunology, Charité - Universitätsmedizin Berlin, D-13353 Berlin, Germany.
Berlin Institute of Health Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, D-13353 Berlin, Germany.
Berlin Center for Advanced Therapies (BeCAT), Charité - Universitätsmedizin Berlin, D-13353 Berlin, Germany.
ORCID: 0000-0002-0358-3876

Stephan Schlickeiser (S)

Institute of Medical Immunology, Charité - Universitätsmedizin Berlin, D-13353 Berlin, Germany.
Berlin Institute of Health Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, D-13353 Berlin, Germany.
ORCID: 0000-0003-3142-2890

Leila Amini (L)

Institute of Medical Immunology, Charité - Universitätsmedizin Berlin, D-13353 Berlin, Germany.
Berlin Institute of Health Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, D-13353 Berlin, Germany.
Berlin Center for Advanced Therapies (BeCAT), Charité - Universitätsmedizin Berlin, D-13353 Berlin, Germany.
ORCID: 0000-0003-4855-5905

Sarah Schulenberg (S)

Berlin Institute of Health Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, D-13353 Berlin, Germany.
ORCID: 0000-0003-3719-6652

Desiree J Wendering (DJ)

Institute of Medical Immunology, Charité - Universitätsmedizin Berlin, D-13353 Berlin, Germany.
Berlin Institute of Health Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, D-13353 Berlin, Germany.
Berlin Center for Advanced Therapies (BeCAT), Charité - Universitätsmedizin Berlin, D-13353 Berlin, Germany.

Viqar Banday (V)

Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University, 901 85 Umea, Sweden.
Department of Clinical Microbiology, Immunology, Umea University, 901 85 Umea, Sweden.
ORCID: 0000-0002-5081-2272

Anke Jurisch (A)

Institute of Medical Immunology, Charité - Universitätsmedizin Berlin, D-13353 Berlin, Germany.
Berlin Institute of Health Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, D-13353 Berlin, Germany.
Berlin Center for Advanced Therapies (BeCAT), Charité - Universitätsmedizin Berlin, D-13353 Berlin, Germany.
ORCID: 0000-0002-7794-1517

Rebecca Noster (R)

Berlin Institute of Health Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, D-13353 Berlin, Germany.
ORCID: 0000-0002-1069-0602

Desiree Kunkel (D)

Berlin Institute of Health Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, D-13353 Berlin, Germany.
ORCID: 0000-0002-0054-955X

Nicola R Brindle (NR)

Berlin Institute of Health Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, D-13353 Berlin, Germany.
ORCID: 0000-0001-5406-7241

Ioannis Savidis (I)

Berlin Institute of Health Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, D-13353 Berlin, Germany.

Levent Akyüz (L)

Institute of Medical Immunology, Charité - Universitätsmedizin Berlin, D-13353 Berlin, Germany.
Berlin Institute of Health Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, D-13353 Berlin, Germany.
ORCID: 0000-0003-1093-8505

Jochen Hecht (J)

Centre for Genomic Regulation, Barcelona Institute of Science and Technology, 08003 Barcelona, Spain.
Universitat Pompeu Fabra (UPF), 08002 Barcelona, Spain.

Ulrik Stervbo (U)

Center for Translational Medicine, Medical Clinic I, Marien Hospital Herne, University Hospital of the Ruhr-University Bochum, D-44623 Herne, Germany.
ORCID: 0000-0002-2831-8868

Toralf Roch (T)

Berlin Institute of Health Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, D-13353 Berlin, Germany.
Center for Translational Medicine, Medical Clinic I, Marien Hospital Herne, University Hospital of the Ruhr-University Bochum, D-44623 Herne, Germany.
ORCID: 0000-0003-2948-8700

Nina Babel (N)

Berlin Institute of Health Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, D-13353 Berlin, Germany.
Center for Translational Medicine, Medical Clinic I, Marien Hospital Herne, University Hospital of the Ruhr-University Bochum, D-44623 Herne, Germany.

Petra Reinke (P)

Berlin Institute of Health Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, D-13353 Berlin, Germany.
Berlin Center for Advanced Therapies (BeCAT), Charité - Universitätsmedizin Berlin, D-13353 Berlin, Germany.
ORCID: 0000-0003-0771-4375

Ola Winqvist (O)

Department of Clinical Immunology, Karolinska University Hospital, 17 176 Stockholm, Sweden.

Amir Sherif (A)

Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University, 901 85 Umea, Sweden.
ORCID: 0000-0002-3675-3050

Hans-Dieter Volk (HD)

Institute of Medical Immunology, Charité - Universitätsmedizin Berlin, D-13353 Berlin, Germany.
Berlin Institute of Health Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, D-13353 Berlin, Germany.

Michael Schmueck-Henneresse (M)

Institute of Medical Immunology, Charité - Universitätsmedizin Berlin, D-13353 Berlin, Germany. michael.schmueck-henneresse@charite.de.
Berlin Institute of Health Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, D-13353 Berlin, Germany.
Berlin Center for Advanced Therapies (BeCAT), Charité - Universitätsmedizin Berlin, D-13353 Berlin, Germany.
ORCID: 0000-0001-5964-9179

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Classifications MeSH

questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › The intratumoral CXCR3 chemokine system is...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Chimiokines › Chimiokines CXC › Chimiokine CXCL10 › The intratumoral CXCR3 chemokine system is...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Chimiokines › Chimiokines CXC › Chimiokine CXCL11 › The intratumoral CXCR3 chemokine system is...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Chimiokines › The intratumoral CXCR3 chemokine system is...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Traitement médicamenteux adjuvant › The intratumoral CXCR3 chemokine system is...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The intratumoral CXCR3 chemokine system is...
questionsmedicales.fr › Thérapeutique › Association thérapeutique › Traitement néoadjuvant › The intratumoral CXCR3 chemokine system is...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux chimiokines › Récepteurs CXCR › Récepteurs CXCR3 › The intratumoral CXCR3 chemokine system is...
questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Tumeurs urologiques › Tumeurs de la vessie urinaire › The intratumoral CXCR3 chemokine system is...