Risk Factors and Incidence of Colorectal Cancer According to Major Molecular Subtypes.

Adiposity Age Factors Body Mass Index Cohort Studies Colorectal Neoplasms / epidemiology CpG Islands DNA Methylation Diet Female Follow-Up Studies Genes, ras Humans Incidence Life Style Male Microsatellite Instability Middle Aged Mutation Phenotype Proportional Hazards Models Proto-Oncogene Proteins B-raf / genetics Risk Factors Sex Factors Smoking United States / epidemiology

Journal

JNCI cancer spectrum
ISSN: 2515-5091
Titre abrégé: JNCI Cancer Spectr
Pays: England
ID NLM: 101721827

Informations de publication

Date de publication:
02 2021
Historique:
received: 11 06 2020
revised: 28 08 2020
accepted: 09 09 2020
entrez: 14 1 2021
pubmed: 15 1 2021
medline: 15 1 2021
Statut: epublish

Résumé

Colorectal cancer (CRC) is a heterogeneous disease that can develop via 3 major pathways: conventional, serrated, and alternate. We aimed to examine whether the risk factor profiles differ according to pathway-related molecular subtypes. We examined the association of 24 risk factors with 4 CRC molecular subtypes based on a combinatorial status of microsatellite instability (MSI), CpG island methylator phenotype (CIMP), and We documented 1175 CRC patients with molecular subtype data: subtype 1 (n = 498; conventional pathway; non-MSI-high, CIMP-low or negative, Risk factor profiles may differ for CRC arising from different molecular pathways.

Sections du résumé

Background
Colorectal cancer (CRC) is a heterogeneous disease that can develop via 3 major pathways: conventional, serrated, and alternate. We aimed to examine whether the risk factor profiles differ according to pathway-related molecular subtypes.
Methods
We examined the association of 24 risk factors with 4 CRC molecular subtypes based on a combinatorial status of microsatellite instability (MSI), CpG island methylator phenotype (CIMP), and
Results
We documented 1175 CRC patients with molecular subtype data: subtype 1 (n = 498; conventional pathway; non-MSI-high, CIMP-low or negative,
Conclusions
Risk factor profiles may differ for CRC arising from different molecular pathways.

Identifiants

DOI: 10.1093/jncics/pkaa089 PMID: 33442661 PMC: PMC7791624
pubmed: 33442661
doi: 10.1093/jncics/pkaa089
pii: pkaa089
pmc: PMC7791624
doi:

Substances chimiques

Proto-Oncogene Proteins B-raf EC 2.7.11.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Subventions

Organisme : NIDDK NIH HHS
ID : K24 DK098311
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA137178
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA230873
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA087969
Pays : United States
Organisme : NCI NIH HHS
ID : R03 CA197879
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA202704
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA151993
Pays : United States
Organisme : NCI NIH HHS
ID : R00 CA215314
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA197735
Pays : United States
Organisme : NCI NIH HHS
ID : K07 CA188126
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA167552
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA167552
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA186107
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA055075
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA127003
Pays : United States

Informations de copyright

© The Author(s) 2020. Published by Oxford University Press.

Références

J Natl Cancer Inst. 2010 Jul 21;102(14):1012-22
pubmed: 20587792
J Mol Diagn. 2006 May;8(2):209-17
pubmed: 16645207
JAMA. 2013 Jun 26;309(24):2563-71
pubmed: 23800934
Cancer Epidemiol Biomarkers Prev. 2003 Nov;12(11 Pt 1):1130-6
pubmed: 14652271
Clin Gastroenterol Hepatol. 2018 Nov;16(11):1754-1761
pubmed: 29902640
Eur J Epidemiol. 2007;22(5):349-50
pubmed: 17484025
Gut. 2011 Mar;60(3):397-411
pubmed: 21036793
J Mol Diagn. 2005 Aug;7(3):413-21
pubmed: 16049314
Int J Cancer. 2017 Apr 1;140(7):1485-1493
pubmed: 27943267
Gastroenterology. 2017 Jan;152(1):92-104
pubmed: 27639804
Gastroenterology. 2013 Aug;145(2):348-56.e1-2
pubmed: 23665275
Am J Clin Nutr. 1997 Apr;65(4 Suppl):1220S-1228S; discussion 1229S-1231S
pubmed: 9094926
Ann Intern Med. 1998 May 1;128(9):705-12
pubmed: 9556463
Int J Cancer. 2014 May 15;134(10):2458-67
pubmed: 24493161
Proc Natl Acad Sci U S A. 2001 May 8;98(10):5770-5
pubmed: 11296254
Annu Rev Pathol. 2019 Jan 24;14:83-103
pubmed: 30125150
J Nutr. 2016 Aug;146(8):1560-70
pubmed: 27358416
J Natl Cancer Inst. 2006 Dec 6;98(23):1731-8
pubmed: 17148775
Am J Clin Nutr. 2018 Aug 1;108(2):363-370
pubmed: 29901698
Gastroenterology. 2017 Dec;153(6):1517-1530.e14
pubmed: 28865736
N Engl J Med. 2015 Jun 25;372(26):2509-20
pubmed: 26028255
Int J Obes (Lond). 2008 Nov;32(11):1716-9
pubmed: 18725892
J Clin Oncol. 2017 Jun 1;35(16):1836-1844
pubmed: 28406723
N Engl J Med. 2007 May 24;356(21):2131-42
pubmed: 17522398
Histopathology. 2007 Jan;50(1):113-30
pubmed: 17204026
Am J Public Health. 2016 Sep;106(9):1599-607
pubmed: 27459444
Am J Epidemiol. 2013 Jul 1;178(1):84-100
pubmed: 23788674
Am J Gastroenterol. 2017 Mar;112(3):493-501
pubmed: 28117362
J Natl Cancer Inst. 2010 Mar 17;102(6):391-400
pubmed: 20208017
Stat Med. 2016 Feb 28;35(5):782-800
pubmed: 26619806
J Mol Diagn. 2007 Jul;9(3):305-14
pubmed: 17591929
Nutr Cancer. 2011;63(7):1000-10
pubmed: 21875327
Carcinogenesis. 2009 Jul;30(7):1073-81
pubmed: 19468060
BMC Cancer. 2019 Jul 11;19(1):681
pubmed: 31296182
Mutat Res. 2001 Nov 1;483(1-2):73-81
pubmed: 11600135
Front Oncol. 2019 May 14;9:396
pubmed: 31139574
Int J Epidemiol. 2012 Aug;41(4):1060-72
pubmed: 22531127
Carcinogenesis. 2002 Nov;23(11):1807-10
pubmed: 12419828
J Nutr Biochem. 2006 Mar;17(3):145-56
pubmed: 16426829
Gastroenterology. 2015 May;148(6):1244-60.e16
pubmed: 25575572
J Natl Cancer Inst. 2015 Nov 23;108(4):
pubmed: 26598515
Nature. 1998 Dec 17;396(6712):643-9
pubmed: 9872311
Gastroenterology. 2017 Jun;152(8):1944-1953.e1
pubmed: 28249812
Eur J Epidemiol. 2017 May;32(5):409-418
pubmed: 28646407
Eur J Epidemiol. 2018 Apr;33(4):381-392
pubmed: 29264788
Gastroenterology. 2018 Aug;155(2):355-373.e18
pubmed: 29702117
Clin Gastroenterol Hepatol. 2018 Oct;16(10):1622-1631.e3
pubmed: 29702299
Gastroenterology. 2010 Jun;138(6):2088-100
pubmed: 20420948
Gastroenterology. 2019 Oct;157(4):949-966.e4
pubmed: 31323292
Nat Hum Behav. 2018 Jan;2(1):6-10
pubmed: 30980045

Auteurs

Liang Wang (L)

Center of Gastrointestinal Surgery, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, P.R. China.
Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.

Xiaosheng He (X)

Department of Colorectal Surgery, the Six Affiliated Hospital, Sun Yat-sen University, Guangzhou, P.R. China.

Tomotaka Ugai (T)

Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Program in MPE Molecular Pathological Epidemiology, Boston, MA, USA.

Koichiro Haruki (K)

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Program in MPE Molecular Pathological Epidemiology, Boston, MA, USA.
ORCID: 0000-0002-1686-3228

Chun-Han Lo (CH)

Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0001-8202-4513

Dong Hang (D)

Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, P.R. China.

Naohiko Akimoto (N)

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Program in MPE Molecular Pathological Epidemiology, Boston, MA, USA.
ORCID: 0000-0001-9880-4143

Kenji Fujiyoshi (K)

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Program in MPE Molecular Pathological Epidemiology, Boston, MA, USA.
ORCID: 0000-0002-0310-5807

Molin Wang (M)

Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA.

Charles S Fuchs (CS)

Department of Medicine, Yale Cancer Center, New Haven, CT, USA.
Department of Medicine, Yale School of Medicine, New Haven, CT, USA.
Department of Medicine, Smilow Cancer Hospital, New Haven, CT, USA.
ORCID: 0000-0003-1582-9842

Jeffrey A Meyerhardt (JA)

Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-1120-0898

Xuehong Zhang (X)

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA, USA.

Kana Wu (K)

Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA, USA.

Andrew T Chan (AT)

Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.

Edward L Giovannucci (EL)

Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA, USA.

Shuji Ogino (S)

Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Program in MPE Molecular Pathological Epidemiology, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Cancer Immunology and Cancer Epidemiology Programs, Dana-Farber Harvard Cancer Center, Boston, MA, USA.
ORCID: 0000-0002-3909-2323

Mingyang Song (M)

Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-1324-0316

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Constitution physique › Composition corporelle › Répartition du tissu adipeux › Adiposité › Risk Factors and Incidence of Colorectal...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Facteurs âges › Risk Factors and Incidence of Colorectal...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Biométrie › Anthropométrie › Indice de masse corporelle › Risk Factors and Incidence of Colorectal...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Risk Factors and Incidence of Colorectal...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du rectum › Tumeurs colorectales › Risk Factors and Incidence of Colorectal...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Ilots CpG › Risk Factors and Incidence of Colorectal...
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › Risk Factors and Incidence of Colorectal...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Risk Factors and Incidence of Colorectal...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études de suivi › Risk Factors and Incidence of Colorectal...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Gènes tumoraux › Oncogènes › Proto-oncogènes › Gènes ras › Risk Factors and Incidence of Colorectal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Risk Factors and Incidence of Colorectal...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Morbidité › Incidence › Risk Factors and Incidence of Colorectal...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Mode de vie › Risk Factors and Incidence of Colorectal...
questionsmedicales.fr › Phénomènes génétiques › Instabilité du génome › Instabilité des microsatellites › Risk Factors and Incidence of Colorectal...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Risk Factors and Incidence of Colorectal...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Risk Factors and Incidence of Colorectal...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Risk Factors and Incidence of Colorectal...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de survie › Modèles des risques proportionnels › Risk Factors and Incidence of Colorectal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Kinases raf › Protéines proto-oncogènes B-raf › Risk Factors and Incidence of Colorectal...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Risk Factors and Incidence of Colorectal...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Facteurs sexuels › Risk Factors and Incidence of Colorectal...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Fumer › Risk Factors and Incidence of Colorectal...
questionsmedicales.fr › Régions géographiques › Amériques › Amérique du Nord › États-Unis › Risk Factors and Incidence of Colorectal...