Cigarette Smoke Activates NOTCH3 to Promote Goblet Cell Differentiation in Human Airway Epithelial Cells.
Bronchi
/ drug effects
Case-Control Studies
Cell Differentiation
/ drug effects
Cells, Cultured
Cigarette Smoking
/ adverse effects
Goblet Cells
/ drug effects
Humans
Non-Smokers
Primary Cell Culture
Pulmonary Disease, Chronic Obstructive
/ etiology
Receptor, Notch3
/ agonists
Signal Transduction
Smoke
/ adverse effects
Smokers
Time Factors
Tobacco Products
/ adverse effects
Transcriptome
COPD
NOTCH signaling
airway epithelial cells
cigarette smoke
goblet cell metaplasia or hyperplasia
Journal
American journal of respiratory cell and molecular biology
ISSN: 1535-4989
Titre abrégé: Am J Respir Cell Mol Biol
Pays: United States
ID NLM: 8917225
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
pubmed:
15
1
2021
medline:
11
5
2021
entrez:
14
1
2021
Statut:
ppublish
Résumé
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the United States and is primarily caused by cigarette smoking. Increased numbers of mucus-producing secretory ("goblet") cells, defined as goblet cell metaplasia or hyperplasia (GCMH), contributes significantly to COPD pathophysiology. The objective of this study was to determine whether NOTCH signaling regulates goblet cell differentiation in response to cigarette smoke. Primary human bronchial epithelial cells (HBECs) from nonsmokers and smokers with COPD were differentiated
Identifiants
pubmed: 33444514
doi: 10.1165/rcmb.2020-0302OC
pmc: PMC8008804
doi:
Substances chimiques
NOTCH3 protein, human
0
Receptor, Notch3
0
Smoke
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
426-440Subventions
Organisme : BLRD VA
ID : I01 BX005023
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM103636
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG050911
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM104938
Pays : United States
Commentaires et corrections
Type : CommentIn
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