An in vivo screen of noncoding loci reveals that


Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
19 01 2021
Historique:
entrez: 15 1 2021
pubmed: 16 1 2021
medline: 18 5 2021
Statut: ppublish

Résumé

Haematopoiesis relies on tightly controlled gene expression patterns as development proceeds through a series of progenitors. While the regulation of hematopoietic development has been well studied, the role of noncoding elements in this critical process is a developing field. In particular, the discovery of new regulators of lymphopoiesis could have important implications for our understanding of the adaptive immune system and disease. Here we elucidate how a noncoding element is capable of regulating a broadly expressed transcription factor, Ikaros, in a lymphoid lineage-specific manner, such that it imbues Ikaros with the ability to specify the lymphoid lineage over alternate fates. Deletion of the

Identifiants

pubmed: 33446502
pii: 1918062118
doi: 10.1073/pnas.1918062118
pmc: PMC7826330
pii:
doi:

Substances chimiques

DNA-Binding Proteins 0
RNA, Untranslated 0
Zfpn1a1 protein, mouse 0
Ikaros Transcription Factor 148971-36-2

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIAID NIH HHS
ID : K22 AI141758
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI110776
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States

Déclaration de conflit d'intérêts

Competing interest statement: R.A.F. is a consultant for GSK and Zai Lab Ltd.

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Auteurs

Christian C D Harman (CCD)

Department of Genetics, Yale School of Medicine, New Haven, CT 06520.
Howard Hughes Medical Institute, New Haven, CT 06520.

Will Bailis (W)

Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104.

Jun Zhao (J)

Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520.
Department of Pathology, Yale School of Medicine, New Haven, CT 06510.
Program of Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520.

Louisa Hill (L)

Research Institute of Molecular Pathology, Vienna Biocenter, 1030 Vienna, Austria.

Rihao Qu (R)

Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520.
Department of Pathology, Yale School of Medicine, New Haven, CT 06510.
Program of Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520.

Ruaidhrí P Jackson (RP)

Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520.

Justin A Shyer (JA)

Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520.

Holly R Steach (HR)

Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520.

Yuval Kluger (Y)

Department of Pathology, Yale School of Medicine, New Haven, CT 06510.
Program of Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520.
Applied Mathematics Program, Yale University, New Haven, CT 06511.

Loyal A Goff (LA)

Broad Institute of MIT and Harvard, Cambridge, MA 02142.
The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.

John L Rinn (JL)

Broad Institute of MIT and Harvard, Cambridge, MA 02142.
Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138.
Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02115.
Department of Biochemistry, University of Colorado, BioFrontiers Institute, Boulder, CO 80301.

Adam Williams (A)

The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032.
Department of Genetics and Genomic Sciences, University of Connecticut Health Center, Farmington, CT 06030.

Jorge Henao-Mejia (J)

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104.

Richard A Flavell (RA)

Howard Hughes Medical Institute, New Haven, CT 06520; richard.flavell@yale.edu.
Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520.

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