An in vivo screen of noncoding loci reveals that
Ikaros
hematopoiesis
lymphocytes
noncoding
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
19 01 2021
19 01 2021
Historique:
entrez:
15
1
2021
pubmed:
16
1
2021
medline:
18
5
2021
Statut:
ppublish
Résumé
Haematopoiesis relies on tightly controlled gene expression patterns as development proceeds through a series of progenitors. While the regulation of hematopoietic development has been well studied, the role of noncoding elements in this critical process is a developing field. In particular, the discovery of new regulators of lymphopoiesis could have important implications for our understanding of the adaptive immune system and disease. Here we elucidate how a noncoding element is capable of regulating a broadly expressed transcription factor, Ikaros, in a lymphoid lineage-specific manner, such that it imbues Ikaros with the ability to specify the lymphoid lineage over alternate fates. Deletion of the
Identifiants
pubmed: 33446502
pii: 1918062118
doi: 10.1073/pnas.1918062118
pmc: PMC7826330
pii:
doi:
Substances chimiques
DNA-Binding Proteins
0
RNA, Untranslated
0
Zfpn1a1 protein, mouse
0
Ikaros Transcription Factor
148971-36-2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : K22 AI141758
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI110776
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Déclaration de conflit d'intérêts
Competing interest statement: R.A.F. is a consultant for GSK and Zai Lab Ltd.
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